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    Natural Products
    3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid
    3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid
    Information
    CAS No. 168293-14-9 Price $238 / 5mg
    Catalog No.CFN90791Purity>=98%
    Molecular Weight512.7Type of CompoundTriterpenoids
    FormulaC32H48O5Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $273.7 / In-stock
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    3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid

    3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid
    Product Name 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid
    CAS No.: 168293-14-9
    Catalog No.: CFN90791
    Molecular Formula: C32H48O5
    Molecular Weight: 512.7 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Targets: NO | NOS | PGE | COX
    Source: The sclerotium of Poria cocos(Schw.) Wolf
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $238 / 5mg
    Inquire / Order: manager@chemfaces.com
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-inflammatory Compound Library
  • Triterpenoids Compound Library
  • PGE Inhibitor Library
  • NOS Inhibitor Library
  • NO Inhibitor Library
  • COX Inhibitor Library
  • Biological Activity
    Description: 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7 cells.
    Targets: NO | NOS | PGE | COX
    In vitro:
    Bioorg Chem. 2017 Feb;70:94-99.
    Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells.[Pubmed: 27912907 ]
    Poria cocos Wolf (Polyporaceae) has been used as a medicinal fungus to treat various diseases since ancient times. This study aimed to investigate the anti-inflammatory chemical constituents of the sclerotia of P. cocos.
    METHODS AND RESULTS:
    Based on bioassay-guided fractionation using lipopolysaccharide (LPS)-stimulated Raw264.7 cells, chemical investigation of the EtOH extract of the sclerotia of P. cocos resulted in the isolation and identification of eight compounds including six triterpenoids, namely poricoic acid A (1), 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid(2), polyporenic acid C (3), 3β-hydroxylanosta-7,9(11),24-trien-21-oic acid (4), trametenolic acid (5), and dehydroeburicoic acid (6), as well as (-)-pinoresinol (7) and protocatechualdehyde (8). The structures of the isolated compounds were determined by spectroscopic analysis, including 1H and 13C NMR spectra, and LC/MS analysis. The anti-inflammatory activities of the isolates were evaluated by estimating their effect on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated Raw264.7 as well as on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Compounds 1-5 inhibited NO production and iNOS expression in LPS-stimulated Raw264.7 cells. Among them, compound 1 exerted the highest anti-inhibitory activity and reduced PGE2 levels via downregulation of COX-2 protein expression.
    CONCLUSIONS:
    The findings of this study provide experimental evidence that the sclerotia of P. cocos are a potential source of natural anti-inflammatory agents for use in pharmaceuticals and functional foods. Furthermore, the most active compound 1, seco-lanostane triterpenoid, could be a promising lead compound for the development of novel anti-inflammatory agents.
    3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid Description
    Source: The sclerotium of Poria cocos(Schw.) Wolf
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9505 mL 9.7523 mL 19.5046 mL 39.0092 mL 48.7615 mL
    5 mM 0.3901 mL 1.9505 mL 3.9009 mL 7.8018 mL 9.7523 mL
    10 mM 0.195 mL 0.9752 mL 1.9505 mL 3.9009 mL 4.8761 mL
    50 mM 0.039 mL 0.195 mL 0.3901 mL 0.7802 mL 0.9752 mL
    100 mM 0.0195 mL 0.0975 mL 0.195 mL 0.3901 mL 0.4876 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Nov 1;1004:10-6. doi: 10.1016/j.jchromb.2015.09.017. Epub 2015 Sep 26.
    One-step separation of nine structural analogues from Poria cocos (Schw.) Wolf. via tandem high-speed counter-current chromatography.[Pubmed: 26435185]
    A novel one-step separation strategy-tandem high-speed counter-current chromatography (HSCCC) was developed with a six-port valve serving as the switch interface.
    METHODS AND RESULTS:
    Nine structural analogues including three isomers were successfully isolated from Poria cocos (Schw.) Wolf. by one step. Compared with conventional HSCCC, peak resolution of target compounds was effectively improved in tandem one. Purities of isolated compounds were all over 90% as determined by HPLC. Their structures were then identified via UV, MS and (1)H NMR, and eventually assigned as poricoic acid B (1), poricoic acid A (2), 3β,16α-dihydroxylanosta-7, 9(11), 24-trien-21-oic acid (3), dehydrotumulosic acid (4), polyporenic acid C (5), 3-epi-dehydrotumulosic acid (6), 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid (7), dehydropachymic acid (8) and dehydrotrametenolic acid (9) respectively.
    CONCLUSIONS:
    The results indicated that tandem HSCCC can effectively improve peak resolution of target compounds, and can be a good candidate for HSCCC separation of structural analogues.
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