4-(Dimethylamino)cinnamic acid | CAS:1552-96-1

4-(Dimethylamino)cinnamic acid

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Product Name	4-(Dimethylamino)cinnamic acid
Price:	$30 / 20mg
CAS No.:	1552-96-1
Catalog No.:	CFN98183
Molecular Formula:	C₁₁H₁₃NO₂
Molecular Weight:	191.23 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	White cryst.
Source:	The barks of Cinnamomum cassia Presl
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / $7.0 / In-stock
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Description:

4-(Dimethylamino)cinnamic acid (DMACA) could be as charge transfer (ICT) probe.

In vitro:

Spectrochim Acta A Mol Biomol Spectrosc. 2011 Mar;78(3):942-8.

Interaction of cinnamic acid derivatives with serum albumins: a fluorescence spectroscopic study.[Pubmed: 21247795]

Cinnamic acid (CA) derivatives are known to possess broad therapeutic applications including anti-tumor activity. The present study was designed to determine the underlying mechanism and thermodynamic parameters for the binding of two CA based intramolecular charge transfer (ICT) fluorescent probes, namely, 4-(dimethylamino) cinnamic acid (DMACA) and trans-ethyl p-(dimethylamino) cinnamate (EDAC), with albumins by fluorescence spectroscopy.
METHODS AND RESULTS:
Stern-Volmer analysis of the tryptophan fluorescence quenching data in presence of the added ligand reveals fluorescence quenching constant (κ(q)), Stern-Volmer constant (K(SV)) and also the ligand-protein association constant (K(a)). The thermodynamic parameters like enthalpy (ΔH) and entropy (ΔS) change corresponding to the ligand binding process were also estimated. The results show that the ligands bind into the sub-domain IIA of the proteins in 1:1 stoichiometry with an apparent binding constant value in the range of 10(4) dm(3) mol(-1).
CONCLUSIONS:
In both the cases, the spontaneous ligand binding to the proteins occur through entropy driven mechanism, although the interaction of DMACA is relatively stronger in comparison with EDAC. The temperature dependence of the binding constant indicates the induced change in protein secondary structure.

4-(Dimethylamino)cinnamic acid Description

Source:	The barks of Cinnamomum cassia Presl
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Photochem Photobiol Sci. 2008 Sep;7(9):1063-70.

Fluorimetric studies on the binding of 4-(dimethylamino)cinnamic acid with micelles and bovine serum albumin.[Pubmed: 18754053]

The constrained photophysics of intramolecular charge transfer (ICT) probe 4-(Dimethylamino)cinnamic acid (DMACA) was studied in different surfactant systems as well as in presence of model water soluble protein bovine serum albumin (BSA).
METHODS AND RESULTS:
Binding of the probe in ionic micelles like sodium dodecyl sulfate (SDS) and cetyl trimethyl ammonium bromide (CTAB) causes an increase in ICT fluorescence intensity, whereas, in non-ionic TritonX-100 (TX-100) the intensity decreases with a concomitant increase in emission from locally excited (LE) state. The observations were explained in terms of the different binding affinity, location of the probe and also the nature of specific hydrogen bonding interaction in the excited state nonradiative relaxation process of DMACA. The ICT fluorescence emission yield decreases in BSA due to the locking in of the probe buried in the hydrophobic pocket of the protein structure. SDS induced uncoiling of protein and massive cooperative binding between BSA and SDS is manifested by the release of probe molecules in relatively free aqueous environment.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.2293 mL	26.1465 mL	52.2931 mL	104.5861 mL	130.7326 mL
5 mM	1.0459 mL	5.2293 mL	10.4586 mL	20.9172 mL	26.1465 mL
10 mM	0.5229 mL	2.6147 mL	5.2293 mL	10.4586 mL	13.0733 mL
50 mM	0.1046 mL	0.5229 mL	1.0459 mL	2.0917 mL	2.6147 mL
100 mM	0.0523 mL	0.2615 mL	0.5229 mL	1.0459 mL	1.3073 mL

CFN00057	Merucathinone	107638-80-2	175.23	C₁₁H₁₃NO
CFN00058	Cathinone	71031-15-7	149.19	C₉H₁₁NO
CFN00059	3,4-Dimethoxybenzenepropanamine	14773-42-3	195.26	C₁₁H₁₇NO₂
CFN00072	3,5-Dibromo-4-[3-(dimethylamino)propoxy]cinnamic acid	134276-56-5	407.1	C₁₄H₁₇Br₂NO₃
CFN00083	Kuramerine	21284-19-5	522.66	C₂₈H₄₄NO₈+
CFN00092	Sinapine	18696-26-9	310.36	C₁₆H₂₄NO₅+
CFN98120	4-(Dimethylamino)cinnamaldehyde	6203-18-5	175.23	C₁₁H₁₃NO
CFN98183	4-(Dimethylamino)cinnamic acid	1552-96-1	191.23	C₁₁H₁₃NO₂
CFN98950	Phenylalanine betaine	56755-22-7	207.3	C₁₂H₁₇NO₂
CFN98988	N-(2-Hydroxy-4-methoxyphenyl)acetamide	58469-06-0	181.2	C₉H₁₁NO₃