ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
Licoarylcoumarin
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $351.1 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Anal Biochem.2019, 569:10-15Phytother Res.2019, 33(5):1490-1500Chemistry of Plant Materials....2019...BioResources J.2020, 15(3).Biomed Chromatogr.2019, 8:e4774Dicle Tip Dergisi2020, 47(2),423-430.Drug Test Anal.2018, 10(10):1579-1589Korean Journal of Medicinal Crop ...2018...
Int J Mol Sci.2021, 22(2):770.Int J Mol Sci.2021, 22(16):8641.Oncotarget.2017, 8(64):108006-108019Sci Rep.2021, 11(1):21038.South African Journal of Botany...2021...Toxins (Basel).2021, 13(9):593. Industrial Food Engineering...2015...Int J Mol Sci.2020, 21(6):2190.
Food Res Int.2018, 106:909-919Aquaculture2017, 481:94-102Phytomedicine.2021, 84:153501. Molecules.2018, 23(12):E3103Chem Biol Interact.2016, 258:59-68J Cell Mol Med.2021, 25(5):2645-2654. Academic J of Second Military Med...2019...
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Our products had been exported to the following research institutions and universities, And still growing.
Regional Crop Research Institute (Korea)Medical University of South Car... (USA)Siksha O Anusandhan University (India)Instytut Nawozów Sztucznych w ... (Poland)
The Ohio State University (USA)Mahidol University (Thailand)University of Mysore (India)Chungnam National University (Korea)
Wroclaw Medical University (Poland)Universidade Federal de Pernamb... (Brazil)Yale University (USA)
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Licoarylcoumarin
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Sci Rep.2017, 7:467-479Pharmacognosy Magazine2017, 13(52):868-874Food and Bioprocess Technology2017, 10(6):1074-1092Asian J Beauty Cosmetol2021, 19(1): 57-64.Biol Pharm Bull.2018, 41(11):1685-1693Acta Pharm Sin B.2015, 5(4):323-9.Phytochem Anal.2013, 24(5):493-503Molecules.2020, 25(18):4283.Sci. Rep.2015, 14-23Toxicol Mech Methods.2021, 1-12.
Related Screening Libraries
| Description: |
Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase. |
| Targets: |
cAMP | HIV | Antifection |
| In vitro: |
| Molecules. 2014 Mar 28;19(4):3883-97. | | Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant Enterococcus species.[Pubmed: 24686577] | Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds.
METHODS AND RESULTS:
Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as Licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study. | | Chem Pharm Bull (Tokyo). 1989 Nov;37(11):3005-9. | | Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase.[Pubmed: 2632045] |
METHODS AND RESULTS:
An anti-HIV (human immunodeficiency virus) phenolic constituent, licopyranocoumarin (4), and two other new phenolics named Licoarylcoumarin (5) and glisoflavone (6) were isolated from Si-pei licorice (a commercial licorice; root and stolon of Glycyrrhiza sp. from the north-western region of China) using droplet countercurrent chromatography and centrifugal partition chromatography, and their structures were assigned based on chemical and spectroscopic data. Kaempferol 3-O-methyl ether (7) and licocoumarone (8) were also isolated from the licorice.
CONCLUSIONS:
The inhibitory effects of ten licorice phenolics on xanthine oxidase were examined. Licochalcone B (1), glycyrrhisoflavone (2), 8 and licochalcone A (19) showed 50% inhibition at the concentration of 1.3-5.6 x 10(-5) M. |
|
Licoarylcoumarin Description
| Source: |
The roots of Glycyrrhiza uralensis. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.7144 mL |
13.5722 mL |
27.1444 mL |
54.2888 mL |
67.861 mL |
| 5 mM |
0.5429 mL |
2.7144 mL |
5.4289 mL |
10.8578 mL |
13.5722 mL |
| 10 mM |
0.2714 mL |
1.3572 mL |
2.7144 mL |
5.4289 mL |
6.7861 mL |
| 50 mM |
0.0543 mL |
0.2714 mL |
0.5429 mL |
1.0858 mL |
1.3572 mL |
| 100 mM |
0.0271 mL |
0.1357 mL |
0.2714 mL |
0.5429 mL |
0.6786 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Chem Pharm Bull (Tokyo). 1991 Apr;39(4):930-3. | | Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by flavonoids from licorice roots and 4-arylcoumarins.[Pubmed: 1654220] | Isoliquiritigenin, glabridin, Licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots.
METHODS AND RESULTS:
The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5,7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase. |
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