Licoarylcoumarin | CAS:125709-31-1 | Manufacturer ChemFaces

Licoarylcoumarin

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Description:

Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase.

Targets:

cAMP | HIV | Antifection

In vitro:

Molecules. 2014 Mar 28;19(4):3883-97.

Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant Enterococcus species.[Pubmed: 24686577]

Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds.
METHODS AND RESULTS:
Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as Licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study.

Chem Pharm Bull (Tokyo). 1989 Nov;37(11):3005-9.

Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase.[Pubmed: 2632045]

METHODS AND RESULTS:
An anti-HIV (human immunodeficiency virus) phenolic constituent, licopyranocoumarin (4), and two other new phenolics named Licoarylcoumarin (5) and glisoflavone (6) were isolated from Si-pei licorice (a commercial licorice; root and stolon of Glycyrrhiza sp. from the north-western region of China) using droplet countercurrent chromatography and centrifugal partition chromatography, and their structures were assigned based on chemical and spectroscopic data. Kaempferol 3-O-methyl ether (7) and licocoumarone (8) were also isolated from the licorice.
CONCLUSIONS:
The inhibitory effects of ten licorice phenolics on xanthine oxidase were examined. Licochalcone B (1), glycyrrhisoflavone (2), 8 and licochalcone A (19) showed 50% inhibition at the concentration of 1.3-5.6 x 10(-5) M.

Licoarylcoumarin Description

Source:	The roots of Glycyrrhiza uralensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Structure Identification:

Chem Pharm Bull (Tokyo). 1991 Apr;39(4):930-3.

Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by flavonoids from licorice roots and 4-arylcoumarins.[Pubmed: 1654220]

Isoliquiritigenin, glabridin, Licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots.
METHODS AND RESULTS:
The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5,7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase.

CAS No.	125709-31-1	Price	$413 / 5mg
Catalog No.	CFN95072	Purity	>=98%
Molecular Weight	368.4	Type of Compound	Coumarins
Formula	C₂₁H₂₀O₆	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web) (SDF)

Product Name	Licoarylcoumarin
CAS No.:	125709-31-1
Catalog No.:	CFN95072
Molecular Formula:	C₂₁H₂₀O₆
Molecular Weight:	368.4 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Targets:	cAMP \| HIV \| Antifection
Source:	The roots of Glycyrrhiza uralensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$413 / 5mg

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Coumarins Compound Library HIV Inhibitor Library cAMP Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7144 mL	13.5722 mL	27.1444 mL	54.2888 mL	67.861 mL
5 mM	0.5429 mL	2.7144 mL	5.4289 mL	10.8578 mL	13.5722 mL
10 mM	0.2714 mL	1.3572 mL	2.7144 mL	5.4289 mL	6.7861 mL
50 mM	0.0543 mL	0.2714 mL	0.5429 mL	1.0858 mL	1.3572 mL
100 mM	0.0271 mL	0.1357 mL	0.2714 mL	0.5429 mL	0.6786 mL

CFN92918	Licopyranocoumarin	117038-80-9	384.38	C₂₁H₂₀O₇
CFN95072	Licoarylcoumarin	125709-31-1	368.4	C₂₁H₂₀O₆
CFN96040	Coumestrol	479-13-0	268.2	C₁₅H₈O₅
CFN96922	4'-O-Methylcoumestrol	1690-62-6	282.25	C₁₆H₁₀O₅
CFN90521	Demethylwedelolactone	6468-55-9	300.21	C₁₅H₈O₇
CFN98857	Wedelolactone	524-12-9	314.3	C₁₆H₁₀O₇
CFN90625	Isodemethylwedelolacton	350681-33-3	300.22	C₁₅H₈O₇
CFN98592	Psoralidin	18642-23-4	336.34	C₂₀H₁₆O₅
CFN90792	Neoglycyrol	23013-84-5	366.4	C₂₁H₁₈O₆
CFN89408	Glycycoumarin	94805-82-0	368.37	C₂₁H₂₀O₆