Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Licoarylcoumarin
    Licoarylcoumarin
    Information
    CAS No. 125709-31-1 Price $413 / 5mg
    Catalog No.CFN95072Purity>=98%
    Molecular Weight368.4Type of CompoundCoumarins
    FormulaC21H20O6Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $351.1 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Regional Crop Research Institute (Korea)
  • Medical University of South Car... (USA)
  • Siksha O Anusandhan University (India)
  • Instytut Nawozów Sztucznych w ... (Poland)
  • The Ohio State University (USA)
  • Mahidol University (Thailand)
  • University of Mysore (India)
  • Chungnam National University (Korea)
  • Wroclaw Medical University (Poland)
  • Universidade Federal de Pernamb... (Brazil)
  • Yale University (USA)
  • More...
  • Package
    Featured Products
    Sibiricaxanthone B

    Catalog No: CFN90644
    CAS No: 241125-81-5
    Price: $238/20mg
    Morusin

    Catalog No: CFN97083
    CAS No: 62596-29-6
    Price: $128/20mg
    Poncirin

    Catalog No: CFN90448
    CAS No: 14941-08-3
    Price: $218/20mg
    Nodakenetin

    Catalog No: CFN98788
    CAS No: 495-32-9
    Price: $218/10mg
    Xanthohumol

    Catalog No: CFN98958
    CAS No: 569-83-5
    Price: $60/20mg
    Przewaquinone A

    Catalog No: CFN92022
    CAS No: 76843-23-7
    Price: $338/5mg
    Kawain

    Catalog No: CFN92656
    CAS No: 500-64-1
    Price: $/mg

    Licoarylcoumarin

    Licoarylcoumarin
    Product Name Licoarylcoumarin
    CAS No.: 125709-31-1
    Catalog No.: CFN95072
    Molecular Formula: C21H20O6
    Molecular Weight: 368.4 g/mol
    Purity: >=98%
    Type of Compound: Coumarins
    Physical Desc.: Powder
    Targets: cAMP | HIV | Antifection
    Source: The roots of Glycyrrhiza uralensis.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $413 / 5mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Sci Rep.2017, 7:467-479
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Food and Bioprocess Technology2017, 10(6):1074-1092
  • Asian J Beauty Cosmetol2021, 19(1): 57-64.
  • Biol Pharm Bull.2018, 41(11):1685-1693
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Phytochem Anal.2013, 24(5):493-503
  • Molecules.2020, 25(18):4283.
  • Sci. Rep.2015, 14-23
  • Toxicol Mech Methods.2021, 1-12.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Coumarins Compound Library
  • HIV Inhibitor Library
  • cAMP Inhibitor Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase.
    Targets: cAMP | HIV | Antifection
    In vitro:
    Molecules. 2014 Mar 28;19(4):3883-97.
    Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant Enterococcus species.[Pubmed: 24686577]
    Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds.
    METHODS AND RESULTS:
    Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as Licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study.
    Chem Pharm Bull (Tokyo). 1989 Nov;37(11):3005-9.
    Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase.[Pubmed: 2632045]

    METHODS AND RESULTS:
    An anti-HIV (human immunodeficiency virus) phenolic constituent, licopyranocoumarin (4), and two other new phenolics named Licoarylcoumarin (5) and glisoflavone (6) were isolated from Si-pei licorice (a commercial licorice; root and stolon of Glycyrrhiza sp. from the north-western region of China) using droplet countercurrent chromatography and centrifugal partition chromatography, and their structures were assigned based on chemical and spectroscopic data. Kaempferol 3-O-methyl ether (7) and licocoumarone (8) were also isolated from the licorice.
    CONCLUSIONS:
    The inhibitory effects of ten licorice phenolics on xanthine oxidase were examined. Licochalcone B (1), glycyrrhisoflavone (2), 8 and licochalcone A (19) showed 50% inhibition at the concentration of 1.3-5.6 x 10(-5) M.
    Licoarylcoumarin Description
    Source: The roots of Glycyrrhiza uralensis.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    Secotubeimoside I

    Catalog No: CFN95347
    CAS No: 106235-32-9
    Price: $318/10mg
    Peiioside B

    Catalog No: CFN95336
    CAS No: 1610618-91-1
    Price: $318/5mg
    3'-Hydroxymirificin

    Catalog No: CFN95102
    CAS No: 168035-02-7
    Price: $338/5mg
    3,3',4',5,6,7,8-heptamethoxyflavon...

    Catalog No: CFN95021
    CAS No: 1178-24-1
    Price: $268/10mg
    Picraquassioside B

    Catalog No: CFN95378
    CAS No: 169312-05-4
    Price: $318/10mg
    3-O-Methylellagic acid 3'-O-alpha-...

    Catalog No: CFN95375
    CAS No: 352280-34-3
    Price: $413/5mg
    Torosachrysone 8-O-beta-gentiobios...

    Catalog No: CFN95131
    CAS No: 94356-13-5
    Price: $318/5mg
    Nortrachelogenin-5'-C-beta-glucosi...

    Catalog No: CFN95251
    CAS No: 858127-39-6
    Price: $318/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7144 mL 13.5722 mL 27.1444 mL 54.2888 mL 67.861 mL
    5 mM 0.5429 mL 2.7144 mL 5.4289 mL 10.8578 mL 13.5722 mL
    10 mM 0.2714 mL 1.3572 mL 2.7144 mL 5.4289 mL 6.7861 mL
    50 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.0858 mL 1.3572 mL
    100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5429 mL 0.6786 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Chem Pharm Bull (Tokyo). 1991 Apr;39(4):930-3.
    Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by flavonoids from licorice roots and 4-arylcoumarins.[Pubmed: 1654220]
    Isoliquiritigenin, glabridin, Licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots.
    METHODS AND RESULTS:
    The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5,7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase.
    Sibiricaxanthone B

    Catalog No: CFN90644
    CAS No: 241125-81-5
    Price: $238/20mg
    Morusin

    Catalog No: CFN97083
    CAS No: 62596-29-6
    Price: $128/20mg
    Poncirin

    Catalog No: CFN90448
    CAS No: 14941-08-3
    Price: $218/20mg
    Nodakenetin

    Catalog No: CFN98788
    CAS No: 495-32-9
    Price: $218/10mg
    Xanthohumol

    Catalog No: CFN98958
    CAS No: 569-83-5
    Price: $60/20mg
    Przewaquinone A

    Catalog No: CFN92022
    CAS No: 76843-23-7
    Price: $338/5mg
    Kawain

    Catalog No: CFN92656
    CAS No: 500-64-1
    Price: $/mg