4-Isopropylbenzaldehyde | CAS:122-03-2

4-Isopropylbenzaldehyde

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Description:

4-Isopropylbenzaldehyde shows acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. 4-Isopropylbenzaldehyde suppressed melanin formation in cultured murine B16-F10 melanoma cells in a dose-dependent decrease up to 0.25 mm without affecting cell growth.

Targets:

AChE | BChE

In vitro:

Phytotherapy Research Ptr, 2010, 22(6):809-813.

Effects of cuminaldehyde on melanoma cells.[Pubmed: 18412105]

METHODS AND RESULTS:
Cuminaldehyde (4-Isopropylbenzaldehyde) suppressed melanin formation in cultured murine B16-F10 melanoma cells in a dose-dependent decrease up to 0.25 mm without affecting cell growth. Approximately 30% suppression in melanin production resulted when the cells were cultured with 0.25 mm of cuminaldehyde. This activity was not noticeable with cultured human A375 melanoma cells.

4-Isopropylbenzaldehyde Description

Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Structure Identification:

Ztschrift Fur Naturforschung C Journal of Bioences, 2008, 63(7-8):547-553.

Activity of essential oils and individual components against acetyl- and butyrylcholinesterase.[Reference: WebLink]

METHODS AND RESULTS:
We have tested acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of nineteen essential oils obtained from cultivated plants, namely one from Anethum graveolens L. (organic fertilizer), two from Foeniculum vulgare Mill. collected at fully-mature and flowering stages (organic fertilizer), two from Melissa officinalis L. (cultivated using organic and chemical fertilizers), two from Mentha piperita L. and M. spicata L. (organic fertilizer), two from Lavandula officinalis Chaix ex Villars (cultivated using organic and chemical fertilizers), two from Ocimum basilicum L. (green and purple-leaf varieties cultivated using only organic fertilizer), four from Origanum onites L., O. vulgare L., O. munitiflorum Hausskn., and O. majorana L. (cultivated using organic fertilizer), two from Salvia sclarea L. (organic and chemical fertilizers), one from S. officinalis L. (organic fertilizer), and one from Satureja cuneifolia Ten. (organic fertilizer) by a spectrophotometric method of Ellman using ELISA microplate-reader at 1 mg/ml concentration. In addition, a number of single components widely encountered in most of the essential oils [gamma-terpinene, 4-allyl anisole, (-)-carvone, dihydrocarvone, (-)-phencone, cuminyl alcohol, cumol, 4-Isopropylbenzaldehyde, trans-anethole, camphene, iso-borneol, (-)-borneol, L-bornyl acetate, 2-decanol, 2-heptanol, methyl-heptanol, farnesol, nerol, iso-pulegol, 1,8-cineole, citral, citronellal, citronellol, geraniol, linalool, alpha-pinene, beta-pinene, piperitone, iso-menthone, menthofurane, linalyl oxide, linalyl ester, geranyl ester, carvacrol, thymol, menthol, vanilline, and eugenol] was also screened for the same activity in the same manner.
CONCLUSIONS:
Almost all of the essential oils showed a very high inhibitory activity (over 80%) against both enzymes, whereas the single components were not as active as the essential oils.

CAS No.	122-03-2	Price	$30 / 20mg
Catalog No.	CFN70043	Purity	>=98%
Molecular Weight	148.2	Type of Compound	Phenols
Formula	C₁₀H₁₂O	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison

Product Name	4-Isopropylbenzaldehyde
CAS No.:	122-03-2
Catalog No.:	CFN70043
Molecular Formula:	C₁₀H₁₂O
Molecular Weight:	148.2 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Targets:	AChE \| BChE
Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$30 / 20mg
Download:	COA MSDS
Similar structural:	Comparison

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library BChE Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.7476 mL	33.7382 mL	67.4764 mL	134.9528 mL	168.691 mL
5 mM	1.3495 mL	6.7476 mL	13.4953 mL	26.9906 mL	33.7382 mL
10 mM	0.6748 mL	3.3738 mL	6.7476 mL	13.4953 mL	16.8691 mL
50 mM	0.135 mL	0.6748 mL	1.3495 mL	2.6991 mL	3.3738 mL
100 mM	0.0675 mL	0.3374 mL	0.6748 mL	1.3495 mL	1.6869 mL

CFN90831	Galloylpaeoniflorin	122965-41-7	632.6	C₃₀H₃₂O₁₅
CFN98839	Hesperidin	520-26-3	610.6	C₂₈H₃₄O₁₅
CFN92120	Wilfornine A	345954-00-9	925.9	C₄₅H₅₁NO₂₀
CFN90753	Dipsanoside A	889678-62-0	1475.4	C₆₆H₉₀O₃₇