ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $351.1 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
JLiquid Chromatography & Related ...2021...Food Res Int.2019, 123:125-134J Nat Med.2017, 71(2):380-388Anticancer Res.2018, 38(4):2127-2135Biochem Pharmacol.2020, 178:114083J Agric Food Chem....2020...Food Chem.2021, 360:130063.Food Engineering Progress...2019...
Evid Based Complement Alternat Me...2017...Nutrients.2020, 12(11):3448. Pharmacognosy Journal....2020...Phytother Res.2018, 32(12):2551-2559Cancers (Basel).2021, 13(6):1432.Aquaculture2017, 481:94-102J Pharmaceut Biomed2020, 178:112894Molecules.2019, 24(17):E3127
Polytechnic University of Catalon...2017...J Ethnopharmacol.2019, 241:112025Journal of Third Military Medical...2019...Biosci Biotechnol Biochem....2020...Appl Biochem Biotechnol....2020...Phytomedicine.2020, 153440. Korean J. Crop Sci.2018, 63(2):131-139
Our products had been exported to the following research institutions and universities, And still growing.
Sri Sai Aditya Institute of Pha... (India)Michigan State University (USA)Ateneo de Manila University (Philippines)Universiti Kebangsaan Malaysia (Malaysia)
University of Parma (Italy)Center for protein Engineering ... (Belgium)Imperial College London (United Kingdom)Universidad Industrial de Santa... (Colombia)
Molecular Biology Institute of ... (Spain)Instituto Politécnico de Bragan?a (Portugal)Siksha O Anusandhan University (India)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
J of Health Science and Alternative Medicine2019, 1(1)Aquaculture2017, 481:94-102Sci Adv.2018, 4(10)Phytochemistry Letters2015, 243-247Plant Direct.2021, 5(12):e372. Journal of Food Hygiene and Safety2019, 34(5):413-420LWT2021, 138:110630.Braz J Med Biol Res. 2016, 49(7)J Anal Toxicol.2021, bkab015.Kor. J. Herbol.2019, 34(2):59-66
Related Screening Libraries
||Licoflavanone exhibits antioxidant and anti-inflammatory activities,it markedly decreases pro-inflammatory cytokines and cyclooxygenase 2/inducible nitric oxide synthase (COX-2/iNOS) expression levels.|
||COX | NOS | NF-kB | MAPK|
|Antioxidants (Basel). 2019 Jun 20;8(6). pii: E186. |
|Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway.[Pubmed: 31226797]|
|Inflammation represents an adaptive response generated by injuries or harmful stimuli. Natural remedies represent an interesting alternative to traditional therapies, involving several biochemical pathways. Besides, the valorization of agrochemical wastes nowadays seems to be a feasible way to reduce the health spending and improve the accessibility at bioactive natural compounds.
METHODS AND RESULTS:
In this context, the chemical composition of three Glycyrrhiza glabra L. (licorice) leaf extracts, obtained through maceration or ultrasound-assisted method (fresh and dried leaves) was investigated. A guided fractionation obtained three main components: pinocembrin, glabranin and Licoflavanone. All the extracts showed similar antioxidant properties, evaluated by 2,2'-diphenyl-1-picrylhydrazyl (DPPH) or 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) Diammonium Salt (ABTS) assay, while, among the isolated compounds, Licoflavanone exhibited the best antioxidant activity. The anti-inflammatory activity of the extracts and the purified compounds was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages. Extract C and Licoflavanone showed a good anti-inflammatory activity without affecting cell viability, as they decreased nitrite levels even when used at 12.5 μg/mL (p < 0.005) and 50 μM concentration (p < 0.001), respectively.
Interestingly, Licoflavanone markedly decreased pro-inflammatory cytokines and cyclooxygenase 2/inducible nitric oxide synthase (COX-2/iNOS) expression levels (p < 0.001). A modulation of nuclear factor kappa B/mitogen-activated protein kinases (NF-kB/MAPK) pathway underlay such behavior, highlighting the potential of this natural compound as a new scaffold in anti-inflammatory drug research.
||The herbs of Erythrina arborescens
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Phytochemistry (Oxford), 1996, 42(3):701-704. |
|Flavonoid variation in the leaves of Glycyrrhiza glabra.[Reference: WebLink]|
METHODS AND RESULTS:
Genistein, pinocembrin, prunetin, 6-prenylnaringenin, Licoflavanone and wighteone were isolated from the leaves of Glycyrrhiza glabra collected on the west coast of Anatolia, whereas lupiwighteone was found only in the leaves of G. glabra growing in middle or east Anatolia.
The G. glabra plants growing in different areas of Turkey could be classified into two types according to the occurrence of lupiwighteone in the leaf.