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3. Inhibitors
Erythro-Guaiacylglycerol-beta-coniferyl aldehyde ether
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $270.3 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Plant Physiol Biochem.2019, 144:355-364Nutrients.2021, 13(1):254. Phytomedicine2022, 104:154337.ACS Synth Biol.2022, doi: 10.1021.Separations2021, 8(1), 1.J Nat Prod.2019, 82(4):1002-1008J Biomed Sci.2020, 27(1):60.Evid Based Complement Alternat Me...2022...
Korean J. Medicinal Crop Sci....2021...Front Immunol.2018, 9:2655Separation Science Plus...2022...Cytotechnology2022, s10616J Pharm Pharmacol.2022, rgac033. Research Square2021, March 3rd.Antioxidants.2022, 11(3):592. Food Chem.2021, 360:130063.
Front Pharmacol.2022, 13:919230. Phytomedicine.2022, 99:154025.Eur Rev Med Pharmacol Sci....2020...Pak J Pharm Sci.2018, 31:311-315J Am Soc Mass Spectrom....2021...J Chromatogr A.2017, 1518:46-58Chem. of Vegetable Raw Materials...2020...
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Our products had been exported to the following research institutions and universities, And still growing.
Kyung Hee University (Korea)Institute of Bioorganic Chemist... (Poland)Fraunhofer-Institut für Moleku... (Germany)Monash University Malaysia (Malaysia)
Universidade Federal de Santa C... (Brazil)Universidade Federal de Pernamb... (Brazil)University of Canterbury (New Zealand)Washington State University (USA)
The Institute of Cancer Research (United Kingdom)Osmania University (India)Charles Sturt University (Denmark)
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Erythro-Guaiacylglycerol-beta-coniferyl aldehyde ether
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J Traditional Thai Medical Res.2022, 8(1):pp1-14.Drug Invention Today2019, 12(6):1303-1306Research on Crops.2017, 18(2)Korean J. Crop Sci.2018, 63(2):131-139Nat Prod Communications2018, 10.1177Front Pharmacol.2022, 13:972825.Biomed Pharmacother.2022, 145:112474. Nutrients.2019, 12(1):E40Sci Rep.2017, 7:467-479J Appl Biol Chem2021, 64(3):245-251.
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Lignans Compound Library |
| Description: |
Erythro-Guaiacylglycerol-beta-coniferyl aldehyde ether,cytotoxic effects on human cancer cell lines |
Erythro-Guaiacylglycerol-beta-coniferyl aldehyde ether Description
| Source: |
The herbs of Leucaena leucocephala |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.6709 mL |
13.3547 mL |
26.7094 mL |
53.4188 mL |
66.7735 mL |
| 5 mM |
0.5342 mL |
2.6709 mL |
5.3419 mL |
10.6838 mL |
13.3547 mL |
| 10 mM |
0.2671 mL |
1.3355 mL |
2.6709 mL |
5.3419 mL |
6.6774 mL |
| 50 mM |
0.0534 mL |
0.2671 mL |
0.5342 mL |
1.0684 mL |
1.3355 mL |
| 100 mM |
0.0267 mL |
0.1335 mL |
0.2671 mL |
0.5342 mL |
0.6677 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Kinase Assay: |
| Bioorg Chem . 2018 Dec;81:382-388 | | Stereoisomeric guaiacylglycerol-β-coniferyl aldehyde ether induces distinctive apoptosis by downregulation of MEK/ERK pathway in hepatocellular carcinoma cells[Pubmed: 30196208] | | Two 8-O-4'-type neolignan epimers erythro-guaiacylglycerol-β-coniferyl aldehyde ether (1) and threo-guaiacylglycerol-β-coniferyl aldehyde ether (2) were isolated from the stems of Picrasma quassioides. Further chiral separation gave two pairs of enantiomers 1a/1b and 2a/2b. The cytotoxicity assay against hepatocellular carcinoma Hep3B and HepG2 cells was evaluated by MTT assay. The results showed that 1b (IC50 = 45.56 μM) and 2b (IC50 = 39.02 μM) had more cytotoxic effect than its enantiomers 1a (IC50 = 82.66 μM) and 2a (IC50 = 67.97 μM) in Hep3B cells, respectively. Moreover, 1b and 2b could induce more apoptotic cells as well as higher reactive oxygen species (ROS) generation than 1a and 2a at 50 μM. In addition, a further study on the phosphoinositide 3-kinase (PI3K)/AKT and mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathways was investigated. The results revealed that all compounds had no significant effect on PI3K/AKT pathway, however, 1b and 2b attenuated the relative levels of p-MEK and p-ERK when compared with 1a and 2a. Taken together, the absolute configurations of guaiacylglycerol-β-coniferyl aldehyde ether had an impact on the inhibitory effect on Hep3B cells. The inactivation of MEK/ERK signaling pathway might contribute to apoptosis induction and ROS generation in 1b- and 2b-treated cells. |
|
| Structure Identification: |
| Arch Pharm Res . 2007 Apr;30(4):402-407 | | Lignans from the fruits of Cornus kousa Burg. and their cytotoxic effects on human cancer cell lines[Pubmed: 17489353] | | The fruits of Cornus kousa Burg. were extracted with 80% aqueous MeOH, and the concentrated extract partitioned with EtOAc, n-BuOH and H2O. Six lignans were isolated from the EtOAc fraction through repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the physico-chemical data, including NMR, MS and IR, the chemical structures of the compounds were determined to be (+)-pinoresinol (1), (-)-balanophonin (2), (+)-laricresinol (3), Erythro-Guaiacylglycerol-beta-coniferyl aldehyde ether (4), threo-guaiacylglycerol-beta-coniferyl aldehyde ether (5) and dihydrodehydrodiconiferyl alcohol (6), which were isolated for the first time from this plant. Most of these compounds showed cytotoxicity against human colon carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines in vitro, with IC50 values ranging from 19.1 to 71.3 microg/mL. |
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