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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Evid Based Complement Alternat Me...2016...Molecules.2017, 22(2)Biochem Biophys Res Commun....2017...The Japan Society for Analytical ...2017...Korean j.of Pharm.2017, 70-76Molecules.2018, 23(11):E2837Chemistry of Natural Compounds...2018...Front Pharmacol.2018, 9:236
Evid Based Complement Alternat Me...2019...Molecules.2019, 24(19):E3417J of the Korean Society of Food S...2019...FASEB J.2019, 33(2):2026-2036The Korea Journal of Herbology...2019...Cell Physiol Biochem....2019...Genes Genomics.2020, 10.1007Antioxidants (Basel).2020, 9(2):E99
Biomed Pharmacother.2020, 125:109784.Biomed Pharmacother.2020, 128:110318.Pharmacol Res.2020, 161:105205.J Neuroinflammation.2020, 17(1):75.Exp Mol Med.2020, 52(4):629-642.Nature Ecology & Evolution...2020...Functional Ecology2020, doi: 10.1111.
Our products had been exported to the following research institutions and universities, And still growing.
Griffith University (Australia)Massachusetts General Hospital (USA)National Research Council of Ca... (Canada)Chang Gung University (Taiwan)
Sant Gadge Baba Amravati Univer... (India)University of Pretoria (South Africa)Georgia Institute of Technology (USA)Northeast Normal University Cha... (China)
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Molecules.2019, 24(19):E3417Food Funct.2020, 11(2):1322-1333.Antioxidants (Basel).2020, 9(6):526.Molecules.2016, 21(6)Journal of Life Science2017, 233-240Anal Sci.2019, 35(12):1317-1325Curr Top Med Chem.2020, 20(21):1898-1909.Evid Based Complement Alternat Med.2019, 2019:2135351Appl Microbiol Biotechnol.2016, 100(9):3965-77Evid-Based Compl Alt2020, 7202519:13
Related Screening Libraries
|| 6-beta-Hydroxyhyoscyamine and 7 beta-hydroxyhyoscyamine exhibit similar affinities at the muscarinic receptor as scopolamine and atropine. |
|Pharmazie. 1995 Jul;50(7):493-5. |
|Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptors.[Pubmed: 7675895]|
METHODS AND RESULTS:
Fourteen tropane and related alkaloids were analyzed for their affinity for nicotinic and/or muscarinic acetylcholine receptors. The biogenetic intermediates littorine, 6-beta-Hydroxyhyoscyamine, 7 beta-hydroxyhyoscyamine exhibit similar affinities at the muscarinic receptor as scopolamine and atropine.
The quarternary derivatives N-methylatropine and N-methylscopolamine show the highest binding with IC50 values of less than 100 pM and 300 pM, respectively. The tropane alkaloids (including cocaine) also bind to the nicotinic acetylcholine receptor, albeit with much lower affinities.
||The roots of Anisodus tanguticus
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Planta Med. 2005 Mar;71(3):249-53. |
|Molecular cloning, expression and characterization of hyoscyamine 6beta-hydroxylase from hairy roots of Anisodus tanguticus.[Pubmed: 15770546]|
METHODS AND RESULTS:
Anisodus tanguticus, one of the indigenous Chinese ethnological medicinal plants of the Solanaceae, produces anticholinergic alkaloids such as hyoscyamine, 6 beta-hydroxyhyoscyamine and scopolamine. Hyoscyamine 6 beta-hydroxylase (H6H), a key enzyme in the biosynthetic pathway of scopolamine, catalyzes the hydroxylation of hyoscyamine and epoxide formation from 6-beta-Hydroxyhyoscyamine to generate scopolamine. A full-length cDNA of H6H has been isolated from A. tanguticus hairy roots. Nucleotide sequence analysis of the cloned cDNA revealed an open reading frame of 1035 bp encoding 344 amino acids with high homology to other known H6Hs. The equivalent amino acid sequence shows a typical motif of 2-oxoglutarate-dependent dioxygenase. The A. tanguticus H6H was expressed in Escherichia coli and purified for enzyme function analysis.
This study characterized the recombinant AtH6H and showed it could generate scopolamine from hyoscyamine.
|Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 2002;(120):85-8. |
|Tropane alkaloids in auxin-independent root cultures of Physochlaina physaloides.[Pubmed: 12638187]|
METHODS AND RESULTS:
Adventitious and hairy root cultures of Physochlaina physaloides were established. These roots grew well and produced high amounts of tropane alkaloids (particularly hyoscyamine and 6-beta-Hydroxyhyoscyamine) in auxin-free culture medium. The effects of basal media and temperature on the growth and alkaloid production of these roots were investigated.
Both root cultures produced highest amount of tropane alkaloids in B5 medium though the optimum temperature for hairy roots were lower than that for adventitious roots.