ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
How to Order
Orders via your E-mail:
1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: email@example.com
Order & Inquiry & Tech Support
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J Food Composition and Analysis...2022...Biochem Biophys Res Commun....2017...J Adv Res.2021, 35:245-257. Appl Biol Chem2019, 62:46Korean J. Medicinal Crop Sci....2018...J Korean Society of Food Science ...2021...Biochem Biophys Res Commun....2018...Scientific World Journal....2014...
Int J Biol Macromol.2019, 126:653-661J Control Release.2021, 336:159-168. Biomed Pharmacother.2022, 145:112474. Bulletin of Health Research...2016...BMC Complement Altern Med....2019...The Korea Journal of Herbology...2020...Korea Institute of Oriental Medic...2020...Nat Prod Sci.2014, 20(3):182-190
Oxid Med Cell Longev....2020...Am J Chin Med.2016, 44(8):1719-1735The Malaysian journal of patholog...2019...Acta horticulturae2017, 1158:257-268Eur J Pharmacol.2021, 906:174220.Pharmacognosy Journal....2020...In Vitro Cellular & Developmental...2021...
Our products had been exported to the following research institutions and universities, And still growing.
Sri Ramachandra University (India)The Institute of Cancer Research (United Kingdom)Research Unit Molecular Epigene... (Germany)Universidade Federal de Santa C... (Brazil)
University of Illinois (USA)Universidad de Ciencias y Artes... (Mexico)Center for protein Engineering ... (Belgium)Sant Gadge Baba Amravati Univer... (India)
Anna University (India)Mahatma Gandhi University (India)University of Sao Paulo (Brazil)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
J Ethnopharmacol.2019, 241:112025Phytochem Anal.2013, 24(5):493-503Drug Chem Toxicol.2020, 1-12.Nat Prod Sci.2018, 24(3):206Agronomy2020, 10(3),388.Korean Journal of Pharmacognosy2017, 48(4):320-328Phytother Res.2015, 29(7):1088-96Sci Rep.2021, 11(1):11936.Carbohydrate Polymer Technologies & App.2021, 2:100049.Pharmaceuticals (Basel).2021, 14(10):1046.
Related Screening Libraries
|| 6-beta-Hydroxyhyoscyamine and 7 beta-hydroxyhyoscyamine exhibit similar affinities at the muscarinic receptor as scopolamine and atropine. |
|Pharmazie. 1995 Jul;50(7):493-5. |
|Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptors.[Pubmed: 7675895]|
METHODS AND RESULTS:
Fourteen tropane and related alkaloids were analyzed for their affinity for nicotinic and/or muscarinic acetylcholine receptors. The biogenetic intermediates littorine, 6-beta-Hydroxyhyoscyamine, 7 beta-hydroxyhyoscyamine exhibit similar affinities at the muscarinic receptor as scopolamine and atropine.
The quarternary derivatives N-methylatropine and N-methylscopolamine show the highest binding with IC50 values of less than 100 pM and 300 pM, respectively. The tropane alkaloids (including cocaine) also bind to the nicotinic acetylcholine receptor, albeit with much lower affinities.
||The roots of Anisodus tanguticus
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Catalog No: CFN95084
CAS No: 141846-47-1
Catalog No: CFN95220
CAS No: 88010-62-2
Catalog No: CFN95054
CAS No: 83864-78-2
Catalog No: CFN95041
CAS No: 80229-08-9
Catalog No: CFN95316
CAS No: 90850-99-0
Catalog No: CFN95151
CAS No: 957110-26-8
Catalog No: CFN95276
CAS No: 71781-79-8
Catalog No: CFN95376
CAS No: 74064-17-8
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Planta Med. 2005 Mar;71(3):249-53. |
|Molecular cloning, expression and characterization of hyoscyamine 6beta-hydroxylase from hairy roots of Anisodus tanguticus.[Pubmed: 15770546]|
METHODS AND RESULTS:
Anisodus tanguticus, one of the indigenous Chinese ethnological medicinal plants of the Solanaceae, produces anticholinergic alkaloids such as hyoscyamine, 6 beta-hydroxyhyoscyamine and scopolamine. Hyoscyamine 6 beta-hydroxylase (H6H), a key enzyme in the biosynthetic pathway of scopolamine, catalyzes the hydroxylation of hyoscyamine and epoxide formation from 6-beta-Hydroxyhyoscyamine to generate scopolamine. A full-length cDNA of H6H has been isolated from A. tanguticus hairy roots. Nucleotide sequence analysis of the cloned cDNA revealed an open reading frame of 1035 bp encoding 344 amino acids with high homology to other known H6Hs. The equivalent amino acid sequence shows a typical motif of 2-oxoglutarate-dependent dioxygenase. The A. tanguticus H6H was expressed in Escherichia coli and purified for enzyme function analysis.
This study characterized the recombinant AtH6H and showed it could generate scopolamine from hyoscyamine.
|Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 2002;(120):85-8. |
|Tropane alkaloids in auxin-independent root cultures of Physochlaina physaloides.[Pubmed: 12638187]|
METHODS AND RESULTS:
Adventitious and hairy root cultures of Physochlaina physaloides were established. These roots grew well and produced high amounts of tropane alkaloids (particularly hyoscyamine and 6-beta-Hydroxyhyoscyamine) in auxin-free culture medium. The effects of basal media and temperature on the growth and alkaloid production of these roots were investigated.
Both root cultures produced highest amount of tropane alkaloids in B5 medium though the optimum temperature for hairy roots were lower than that for adventitious roots.