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3. Inhibitors
Biatractylolide
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $174.2 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Int J Mol Sci.2022, 23(5):2796. Cancers (Basel).2021, 13(9):2223.Life Sci.2019, 216:259-270J Asian Nat Prod Res.2019, 5:1-17Mie University2019, 10076.Biomol Ther (Seoul).2023, 31(1):40-47.J Agric Food Chem....2021...Anal Bioanal Chem.2016, 408(1):177-90.
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Biatractylolide
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manager@chemfaces.com
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service@chemfaces.com
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+86-27-84254680
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ACS Omega2020, 5,33,20825-20830Life (Basel).2022, 12(10):1630.Mol Cell.2017, 68(4):673-685Int J Mol Sci.2015, 16(1):1232-51ACS Synth Biol.2020, 9(9):2282-2290.Evid Based Complement Alternat Med.2016, 2016:1739760Molecules.2019, 24(9):E1719Antioxidants (Basel).2022, 11(12):2327.J Appl Biol Chem.2021, 64(3),263?268New Journal of Chemistry2019, 43:12538-12547
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
Biatractylolide has a neuroprotective effect on glutamate-induced injury in PC12 and SH-SY5Y cells through a mechanism of the PI3K-Akt-GSK3β-dependent pathways. The molecular mechanisms of inhibitory activities of biatractylolide on AChE are not only through binding to AChE, but also via reducing AChE expression by inhibiting the activity of GSK3β. |
| Targets: |
PI3K | Akt | GSK3β | AChR |
| In vitro: |
| Evid Based Complement Alternat Med. 2017;2017:1291458. | | Biatractylolide Modulates PI3K-Akt-GSK3β-Dependent Pathways to Protect against Glutamate-Induced Cell Damage in PC12 and SH-SY5Y Cells.[Pubmed: 29075302] | Biatractylolide, isolated from the ethyl acetate extract of Atractylodes macrocephala, has shown various pharmacological activities such as antitumor and antioxidant activities.
CONCLUSIONS:
In this work, we aim to study the protective effect of Biatractylolide on glutamate-induced rat adrenal pheochromocytoma cell (PC12) and human bone marrow neuroblastoma cell line (SH-SY5Y) injury and preliminarily explore its mechanism. The results showed that glutamate was cytotoxic with an inhibitory concentration 50% (IC50) of 8.5 mM in PC12 and 10 mM in SH-SY5Y cells. In this work, the preincubation with Biatractylolide (10, 15, and 20 μM) observably improved cell viability, inhibited the apoptosis of cells induced by glutamate, and reduced the activity of LDH. AO staining revealed that apoptosis of cells was decreased. Additionally, the results of western blotting manifested that pretreatment with Biatractylolide could downregulate GSK3β protein expression and upregulate p-Akt protein expression, thereby protecting PC12 and SH-SY5Y cells from injury.
CONCLUSIONS:
All these findings indicate that Biatractylolide has a neuroprotective effect on glutamate-induced injury in PC12 and SH-SY5Y cells through a mechanism of the PI3K-Akt-GSK3β-dependent pathways. |
|
Biatractylolide Description
| Source: |
The roots of Atractylodes macrocephala |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.1617 mL |
10.8085 mL |
21.6169 mL |
43.2339 mL |
54.0424 mL |
| 5 mM |
0.4323 mL |
2.1617 mL |
4.3234 mL |
8.6468 mL |
10.8085 mL |
| 10 mM |
0.2162 mL |
1.0808 mL |
2.1617 mL |
4.3234 mL |
5.4042 mL |
| 50 mM |
0.0432 mL |
0.2162 mL |
0.4323 mL |
0.8647 mL |
1.0808 mL |
| 100 mM |
0.0216 mL |
0.1081 mL |
0.2162 mL |
0.4323 mL |
0.5404 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Kinase Assay: |
| Evid Based Complement Alternat Med. 2016;2016:7481323. | | Primary Investigation for the Mechanism of Biatractylolide from Atractylodis Macrocephalae Rhizoma as an Acetylcholinesterase Inhibitor.[Pubmed: 27642355] |
METHODS AND RESULTS:
Biatractylolide was isolated from ethyl acetate extract of dried Atractylodis Macrocephalae Rhizoma root by multistep chromatographic processing. Structure of Biatractylolide was confirmed by (1)H-NMR and (13)C-NMR. The IC50 on acetylcholinesterase (AChE) activity was 6.5458 μg/mL when the control IC50 value of huperzine A was 0.0192 μg/mL. Molecular Docking Software (MOE) was used to discover molecular sites of action between Biatractylolide and AChE protein by regular molecular docking approaches. Moreover, Biatractylolide downregulated the expression of AChE of MEF and 293T cells in a dose-dependent manner.
CONCLUSIONS:
These results demonstrated that the molecular mechanisms of inhibitory activities of Biatractylolide on AChE are not only through binding to AChE, but also via reducing AChE expression by inhibiting the activity of GSK3β. |
|
| Structure Identification: |
| Chem Pharm Bull (Tokyo). 2002 Jul;50(7):964-5. | | The crystal structure of biatractylolide, an 8,8' (C-C) linked dimeric 12,8-eudesmanolide from the resin of Trattinickia rhoifolia WILLD.[Pubmed: 12130855 ] |
METHODS AND RESULTS:
A symmetrical dimeric sesquiterpenoid, Biatractylolide (1), was isolated from the resin of Trattinickia rhoifolia WILLD.
CONCLUSIONS:
The structure of compound 1 was elucidated by one- and two-dimensional NMR techniques and electron impact-mass spectra (EI-MS) data, and confirmed by X-ray crystallographic analysis. |
|
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