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- Product Intended Use
- 1. Reference standards
- 2. Pharmacological research
- 3. Inhibitors
7,3',4'-Trihydroxyflavone
ChemFaces products have been cited in many studies from excellent and top scientific journals
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $34.9 / In-stock |
| Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Our products had been exported to the following research institutions and universities, And still growing.
- Universidad de Buenos Aires (Argentina)
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- Uniwersytet Medyczny w ?odzi (Poland)
- University of Bordeaux (France)
- Chungnam National University (Korea)
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- More...
- Phytomedicine.2022, 100:154036.
- Horticulturae2022, 8(10), 975.
- J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
- Br J Pharmacol.2020, 10.1111
- Phytother Res.2018, 32(5):923-932
- J Sci Food Agric.2022, 102(4):1628-1639
- Natural Product Res.&Deve.2022, 1001-6880.
- BMC Complement Altern Med.2017, 17(1):393
- Molecules.2020, 25(23):5636.
- Journal of Ginseng Research2019, 10.1016
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
| Related Libraries |
|
| Description: |
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs), it inhibits osteoclastogenesis via nuclear factor of activated T cells c1 (NFATc1). |
| Targets: |
p38MAPK | NF-kB | ATPase | RANKL |
7,3',4'-Trihydroxyflavone Description
| Source: |
The seeds of Cassia occidentalis |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.7004 mL |
18.5021 mL |
37.0041 mL |
74.0083 mL |
92.5104 mL |
| 5 mM |
0.7401 mL |
3.7004 mL |
7.4008 mL |
14.8017 mL |
18.5021 mL |
| 10 mM |
0.37 mL |
1.8502 mL |
3.7004 mL |
7.4008 mL |
9.251 mL |
| 50 mM |
0.074 mL |
0.37 mL |
0.7401 mL |
1.4802 mL |
1.8502 mL |
| 100 mM |
0.037 mL |
0.185 mL |
0.37 mL |
0.7401 mL |
0.9251 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Kinase Assay: |
| Pharmazie, 2015, 70(10):661-7. | | 3'4'7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1.[Pubmed: 26601423] | 3'4'7-Trihydroxyflavone(7,3',4'-Trihydroxyflavone) is a flavonoid from ladino clover, alfalfa, and Albizzia julibrissin .
METHODS AND RESULTS:
In the present study, we found that 3'4'7-trihydroxyflavone markedly inhibited the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs). 3'4'7-trihydroxyflavone also reduced the mRNA expression level of osteoclastic marker genes including calcitonin receptor (CTR), Cathepsin K, v-ATPase V0 subunit d2 (ATP6v0d2), and dendritic cell-specific transmembrane protein (DC-STAMP). In addition, 3'4'7-trihydroxyflavone decreased the bone resorption activity of osteoclasts on dentin slices. We found that 3'4'7-trihydroxyflavone inhibited RANKL-induced expression of nuclear factor of activated T cells c1 (NFATc1), a key transcription factor of osteoclast differentiation. Furthermore, 3'4'7-trihydroxyflavone attenuated RANKL-induced activation of p38 mitogenactivated protein kinase (MAPK) and expression of B lymphocyte-induced maturation protein 1 (Blimp1), a repressor of negative regulators of NFATc1.
CONCLUSIONS:
Taken together, our data suggest that 3'4'7-trihydroxyflavone inhibits osteoclastogenesis NFATc1. |
|
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