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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $34.9 / In-stock||Other Packaging
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More articles cited ChemFaces products.
Asian Journal of Chemistry...2014...Mol Med Rep.2015, 12(5):7789-95J Ethnopharmacol.2016, 194:219-227J Ethnopharmacol.2017, 206:327-336J Biochem Mol Toxicol.2017, 31(9)Hum Exp Toxicol.2017, 36(11):1169-1176Front Immunol.2017, 8:1542Anal Chim Acta.2018, 1039:162-171
Evid Based Complement Alternat Me...2018...Life Sci.2018, 209:498-506Phytother Res.2018, 32(12):2551-2559Industrial Crops and Products...2018...J Sep Sci.2018, 41(9):1938-1946Cell Death Dis.2019, 10(12):882Journal of Food Hygiene and Safet...2019...Phytomedicine.2019, 57:95-104
J Mater Chem B.2019, 7(39):5896-5919Agronomy2020, 10(10),1489Int J Biol Macromol....2020...Molecules.2020, 25(9):2111.Plant Sci.2020, 301:110656.BMB Rep.2020, 53(4):218-222.Plants (Basel).2020, 9(11):1422.
Our products had been exported to the following research institutions and universities, And still growing.
Chungnam National University (Korea)Almansora University (Egypt)Korea Institute of Oriental Med... (Korea)Deutsches Krebsforschungszentrum (Germany)
Universiti Malaysia Pahang (Malaysia)The Vancouver Prostate Centre (... (Canada)Mahatma Gandhi University (India)National Cancer Center Research... (Japan)
Aarhus University (Denmark)Universidade da Beira Interior (Germany)Mahidol University (Thailand)
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J. of Agricultural Science2015, 1916-9760Int J Mol Sci.2018, 19(9):E2528Pharmacognosy Journal2019, 11(2): 369-373J Nat Med.2018, 72(3):734-744Evid-Based Compl Alt2020, 7202519:13Evid Based Complement Alternat Med.2017, 2017:9764843Molecules.2019, 24(23):E4303Arch Pharm Res.2015, 38(6):1080-9Korean J of Pharmacognosy2020, 51,49-54.J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
Related Screening Libraries
|| 3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs), it inhibits osteoclastogenesis via nuclear factor of activated T cells c1 (NFATc1).|
||p38MAPK | NF-kB | ATPase | RANKL|
||The seeds of Cassia occidentalis
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Pharmazie, 2015, 70(10):661-7. |
|3'4'7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1.[Pubmed: 26601423]|
|3'4'7-Trihydroxyflavone(7,3',4'-Trihydroxyflavone) is a flavonoid from ladino clover, alfalfa, and Albizzia julibrissin .
METHODS AND RESULTS:
In the present study, we found that 3'4'7-trihydroxyflavone markedly inhibited the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs). 3'4'7-trihydroxyflavone also reduced the mRNA expression level of osteoclastic marker genes including calcitonin receptor (CTR), Cathepsin K, v-ATPase V0 subunit d2 (ATP6v0d2), and dendritic cell-specific transmembrane protein (DC-STAMP). In addition, 3'4'7-trihydroxyflavone decreased the bone resorption activity of osteoclasts on dentin slices. We found that 3'4'7-trihydroxyflavone inhibited RANKL-induced expression of nuclear factor of activated T cells c1 (NFATc1), a key transcription factor of osteoclast differentiation. Furthermore, 3'4'7-trihydroxyflavone attenuated RANKL-induced activation of p38 mitogenactivated protein kinase (MAPK) and expression of B lymphocyte-induced maturation protein 1 (Blimp1), a repressor of negative regulators of NFATc1.
Taken together, our data suggest that 3'4'7-trihydroxyflavone inhibits osteoclastogenesis NFATc1.