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    Natural Products
    7,3',4'-Trihydroxyflavone
    7,3',4'-Trihydroxyflavone
    Information
    CAS No. 2150-11-0 Price $118 / 20mg
    Catalog No.CFN97786Purity>=98%
    Molecular Weight270.24Type of CompoundFlavonoids
    FormulaC15H10O5Physical DescriptionYellow powder
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $34.9 / In-stock
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    7,3',4'-Trihydroxyflavone

    7,3',4'-Trihydroxyflavone
    Product Name 7,3',4'-Trihydroxyflavone
    CAS No.: 2150-11-0
    Catalog No.: CFN97786
    Molecular Formula: C15H10O5
    Molecular Weight: 270.24 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Yellow powder
    Targets: p38MAPK | NF-kB | ATPase | RANKL
    Source: The seeds of Cassia occidentalis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $118 / 20mg
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  • J. of Agricultural Science2015, 1916-9760
  • Int J Mol Sci.2018, 19(9):E2528
  • Pharmacognosy Journal2019, 11(2): 369-373
  • J Nat Med.2018, 72(3):734-744
  • Evid-Based Compl Alt2020, 7202519:13
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • Molecules.2019, 24(23):E4303
  • Arch Pharm Res.2015, 38(6):1080-9
  • Korean J of Pharmacognosy2020, 51,49-54.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: 3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs), it inhibits osteoclastogenesis via nuclear factor of activated T cells c1 (NFATc1).
    Targets: p38MAPK | NF-kB | ATPase | RANKL
    7,3',4'-Trihydroxyflavone Description
    Source: The seeds of Cassia occidentalis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7004 mL 18.5021 mL 37.0041 mL 74.0083 mL 92.5104 mL
    5 mM 0.7401 mL 3.7004 mL 7.4008 mL 14.8017 mL 18.5021 mL
    10 mM 0.37 mL 1.8502 mL 3.7004 mL 7.4008 mL 9.251 mL
    50 mM 0.074 mL 0.37 mL 0.7401 mL 1.4802 mL 1.8502 mL
    100 mM 0.037 mL 0.185 mL 0.37 mL 0.7401 mL 0.9251 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Pharmazie, 2015, 70(10):661-7.
    3'4'7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1.[Pubmed: 26601423]
    3'4'7-Trihydroxyflavone(7,3',4'-Trihydroxyflavone) is a flavonoid from ladino clover, alfalfa, and Albizzia julibrissin .
    METHODS AND RESULTS:
    In the present study, we found that 3'4'7-trihydroxyflavone markedly inhibited the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs). 3'4'7-trihydroxyflavone also reduced the mRNA expression level of osteoclastic marker genes including calcitonin receptor (CTR), Cathepsin K, v-ATPase V0 subunit d2 (ATP6v0d2), and dendritic cell-specific transmembrane protein (DC-STAMP). In addition, 3'4'7-trihydroxyflavone decreased the bone resorption activity of osteoclasts on dentin slices. We found that 3'4'7-trihydroxyflavone inhibited RANKL-induced expression of nuclear factor of activated T cells c1 (NFATc1), a key transcription factor of osteoclast differentiation. Furthermore, 3'4'7-trihydroxyflavone attenuated RANKL-induced activation of p38 mitogenactivated protein kinase (MAPK) and expression of B lymphocyte-induced maturation protein 1 (Blimp1), a repressor of negative regulators of NFATc1.
    CONCLUSIONS:
    Taken together, our data suggest that 3'4'7-trihydroxyflavone inhibits osteoclastogenesis NFATc1.
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