8-Dehydroxy shanzhiside | CAS:1008532-71-5

8-Dehydroxy shanzhiside

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Description:

8-Dehydroxy shanzhiside have hemostasis and alleviating pain effects.

In vivo:

Phytother Res . 2009 Jun;23(6):816-822.

Isolation and identification of hemostatic ingredients from Lamiophlomis rotata (Benth.) Kudo[Pubmed: 19173219]

Lamiophlomis rotata (Benth.) Kudo (LR) is a traditional drug used by Chinese minorities such as Tibetans, Mongolians and Na Xi with the beneficial effects of hemostasis and alleviating pain. Flavonoids ingredients (P(1)), iridoid glycosides ingredients (P(2)) and maximus polarity components ingredients (P(3)) were isolated from the aqueous extract of LR (AELR) with polyamide and macroporous adsorptive resins chromatographic columns. The hemostatic activity of these ingredients was estimated by the changes in bleeding time (BT), clotting time (CT) and blood coagulation parameters in mice or rats. RP-HPLC was used to analyze the chemical composition of P(2). As a result, AELR and P(2) significantly shortened BT, CT and thrombin time (TT), and increased fibrinogen (FIB), but P(1) and P(3) showed no hemostatic effect during the experiment. Moreover, P(2) showed satisfactory hemostatic effect with dose-effect relationship and low toxicity in mice. 8-Dehydroxy shanzhiside, phloyoside II, shanzhiside methylester, loganin, and 8-O-acetylshanzhiside methylester were detected as the main iridoid glycosides in P(2) by RP-HPLC. Our results suggest that iridoid glycosides may be the hemostatic activity ingredients of L. rotata and are a potential hemostatic medicine.

8-Dehydroxy shanzhiside Description

Source:	The herbs of Lamiophlomis rotata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Yao Xue Xue Bao . 2011 Oct;46(10):1221-1224.

[Iridoid glycosides from buds of Jasminum officinale L. var. grandiflorum][Pubmed: 22242454]

The study on the buds of Jasminum officinale L. var. grandiflorum was carried out to look for anti-HBV constituents. The isolation and purification were performed by HPLC and chromatography on silica gel, polyamide and Sephadex LH-20 column. The structures were elucidated on the basis of physicochemical properties and spectral analysis. Six iridoid glycosides were identified as jasgranoside B (1), 6-O-methy-catalpol (2), deacetyl asperulosidic acid (3), aucubin (4), 8-Dehydroxy shanzhiside (5), and loganin (6). Jasgranoside B (1) is a new compound. Compounds 2-6 were isolated from Jasminum officinale L. var. grandiflorum for the first time.

Product Name	8-Dehydroxy shanzhiside
Price:
CAS No.:	1008532-71-5
Catalog No.:	CFN91607
Molecular Formula:	C₁₆H₂₄O₁₀
Molecular Weight:	376.36 g/mol
Purity:	>=98%
Type of Compound:	Iridoids
Physical Desc.:	Powder
Source:	The herbs of Lamiophlomis rotata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Iridoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.657 mL	13.2852 mL	26.5703 mL	53.1406 mL	66.4258 mL
5 mM	0.5314 mL	2.657 mL	5.3141 mL	10.6281 mL	13.2852 mL
10 mM	0.2657 mL	1.3285 mL	2.657 mL	5.3141 mL	6.6426 mL
50 mM	0.0531 mL	0.2657 mL	0.5314 mL	1.0628 mL	1.3285 mL
100 mM	0.0266 mL	0.1329 mL	0.2657 mL	0.5314 mL	0.6643 mL

CFN96341	Euphroside	76994-07-5	376.4	C₁₆H₂₄O₁₀
CFN96280	8-Epideoxyloganic acid	88668-99-9	360.4	C₁₆H₂₄O₉
CFN91607	8-Dehydroxy shanzhiside	1008532-71-5	376.36	C₁₆H₂₄O₁₀
CFN98212	Loganic acid	22255-40-9	376.4	C₁₆H₂₄O₁₀
CFN95912	8-epi-Loganic acid	82509-41-9	376.4	C₁₆H₂₄O₁₀
CFN95752	Alboside I	239791-85-6	552.5	C₂₆H₃₂O₁₃
CFN90979	Gentiournoside D	157722-21-9	512.46	C₂₃H₂₈O₁₃
CFN91394	Mussaenosidic acid	82451-22-7	376.4	C₁₆H₂₄O₁₀
CFN98370	Shanzhiside	29836-27-9	392.4	C₁₆H₂₄O₁₁
CFN70455	Negundoside	82451-20-5	496.5	C₂₃H₂₈O₁₂