Ganoderic acid TR | CAS:862893-75-2 | Manufacturer ChemFaces

Ganoderic acid TR

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Product Name	Ganoderic acid TR
Price:	$368 / 5mg
CAS No.:	862893-75-2
Catalog No.:	CFN92235
Molecular Formula:	C₃₀H₄₄O₄
Molecular Weight:	468.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The fruit body of Ganoderma lucidum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $318 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Ganoderic acid TR, a new lanostanoid with 5α-reductase inhibitory activity from the fruiting body of Ganoderma lucidum.

Targets:

5-alpha Reductase

In vitro:

Sci Rep . 2015 Aug 26;5:13194.

Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design[Pubmed: 26307417]

Abstract Neuraminidase (NA) inhibitors are the dominant antiviral drugs for treating influenza in the clinic. Increasing prevalence of drug resistance makes the discovery of new NA inhibitors a high priority. Thirty-one triterpenoids from the medicinal mushroom Ganoderma lingzhi were analyzed in an in vitro NA inhibition assay, leading to the discovery of ganoderic acid T-Q and TR as two inhibitors of H5N1 and H1N1 NAs. Structure-activity relationship studies revealed that the corresponding triterpenoid structure is a potential scaffold for the design of NA inhibitors. Using these triterpenoids as probes we found, through further in silico docking and interaction analysis, that interactions with the amino-acid residues Arg292 and/or Glu119 of NA are critical for the inhibition of H5N1 and H1N1. These findings should prove valuable for the design and development of NA inhibitors.

Ganoderic acid TR Description

Source:	The fruit body of Ganoderma lucidum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Nat. Prod. Commun., 2006, 1(5):345-50.

Ganoderic acid TR, a new lanostanoid with 5α-reductase inhibitory activity from the fruiting body of Ganoderma lucidum[Reference: WebLink]

METHODS AND RESULTS:
By means of 5α-reductase inhibitory activity-guided fractionation, a new lanostanoid, 15α-hydroxy-3-oxolanosta- 7, 9(11), 24(E)-trien-26-oic acid, named as Ganoderic acid TR, was isolated from the ethanol extract of the fruiting bodies of Ganoderma lucidum (Fr.) Karst (Ganodermataceae).
CONCLUSIONS:
The compound showed potent inhibitory activity with an IC50 of 8.5 μM. Modified Mosher's method established the S-configuration of the secondary hydroxyl group at C-15. In addition, a carboxyl group on the side chain of Ganoderic acid TR is essential to elicit the inhibitory activity because of the considerably lower activity of its methyl ester.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Triterpenoids Compound Library 5-alpha Reductase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1336 mL	10.6678 mL	21.3356 mL	42.6712 mL	53.339 mL
5 mM	0.4267 mL	2.1336 mL	4.2671 mL	8.5342 mL	10.6678 mL
10 mM	0.2134 mL	1.0668 mL	2.1336 mL	4.2671 mL	5.3339 mL
50 mM	0.0427 mL	0.2134 mL	0.4267 mL	0.8534 mL	1.0668 mL
100 mM	0.0213 mL	0.1067 mL	0.2134 mL	0.4267 mL	0.5334 mL

CFN99083	Coccinic acid	107783-45-9	454.7	C₃₀H₄₆O₃
CFN92727	Anwuweizonic acid	117020-59-4	454.7	C₃₀H₄₆O₃
CFN92998	7-Oxo-ganoderic acid Z	929248-72-6	470.68	C₃₀H₄₆O₄
CFN99815	Ganoderic acid DM	173075-45-1	468.7	C₃₀H₄₄O₄
CFN95593	11-Keto-ganoderic acid DM	N/A	482.7	C₃₀H₄₂O₅
CFN95568	Ganoderiol D	114567-45-2	488.7	C₃₀H₄₈O₅
CFN95059	Lucidumol A	217476-73-8	472.7	C₃₀H₄₈O₄
CFN80433	23S-hydroxy-11,15-dioxo-ganoderic acid DM	1085273-49-9	512.63	C₃₀H₄₀O₇
CFN95538	New compound 19	N/A	554.7	C₃₂H₄₂O₈
CFN95518	Ganoderic acid GS-3	1206781-66-9	558.7	C₃₂H₄₆O₈