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    Natural Products
    Tumulosic acid
    Tumulosic acid
    Information
    CAS No. 508-24-7 Price $413 / 5mg
    Catalog No.CFN95399Purity>=98%
    Molecular Weight486.7Type of CompoundTriterpenoids
    FormulaC31H50O4Physical DescriptionPowder
    Download Similar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $413 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Tumulosic acid

    Tumulosic acid
    Product Name Tumulosic acid
    CAS No.: 508-24-7
    Catalog No.: CFN95399
    Molecular Formula: C31H50O4
    Molecular Weight: 486.7 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Source: The roots of Wolfiporia cocos
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $413 / 5mg
    Inquire / Order: manager@chemfaces.com
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  • Front Pharmacol.2020, 11:683.
  • Eur Endod J.2020, 5(1):23-27.
  • Nat Prod Sci.2016, 22(2)
  • Free Radic Biol Med.2017, 112:191-199
  • Int J Mol Sci.2017, 19(1)
  • Molecules.2020, 25(15):3353.
  • Biomol Ther (Seoul).2019, 10.4062
  • Oxid Med Cell Longev.2020, 2020:8887251.
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  • J Pharmaceut Biomed2020, 182:113110
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Triterpenoids Compound Library
  • Biological Activity
    Description: Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM.
    In vitro:
    Molecules . 2017 Oct 27;22(11):1829.
    Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources[Pubmed: 29077044]
    Stratum corneum tryptic enzyme kallikrein 5 (KLK5) is a serine protease that is involved in the cell renewal and maintenance of the skin barrier function. The excessive activation of KLK5 causes an exacerbation of dermatoses, such as rosacea and atopic dermatitis. Some triterpenoids are reported to suppress the serine proteases. We aimed to investigate whether bioactive triterpenoids modulate the KLK5 protease. Nineteen triterpenoids occurring in medicinal crude drugs were evaluated using an enzymatic assay to measure the anti-KLK5 activity. The KLK5-dependent cathelicidin peptide LL-37 production in human keratinocytes was examined using immunoprecipitation and Western blotting. Screening assays for evaluating the anti-KLK5 activity revealed that ursolic acid, oleanolic acid, saikosaponin b₁, Tumulosic acid and pachymic acid suppressed the KLK5 protease activity, although critical molecular moieties contributing to anti-KLK5 activity were unclarified. Ursolic acid and Tumulosic acid suppressed the proteolytic processing of LL-37 in keratinocytes at ≤10 μM; no cytotoxicity was observed. Both triterpenoids were detected in the plasma of rats administered orally with triterpenoid-rich crude drug Jumihaidokuto. Our study reveals that triterpenoids, such as ursolic acid and Tumulosic acid, modulate the KLK5 protease activity and cathelicidin peptide production. Triterpenoids may affect the skin barrier function via the regulation of proteases.
    Tumulosic acid Description
    Source: The roots of Wolfiporia cocos
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0547 mL 10.2733 mL 20.5465 mL 41.0931 mL 51.3663 mL
    5 mM 0.4109 mL 2.0547 mL 4.1093 mL 8.2186 mL 10.2733 mL
    10 mM 0.2055 mL 1.0273 mL 2.0547 mL 4.1093 mL 5.1366 mL
    50 mM 0.0411 mL 0.2055 mL 0.4109 mL 0.8219 mL 1.0273 mL
    100 mM 0.0205 mL 0.1027 mL 0.2055 mL 0.4109 mL 0.5137 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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