ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $413 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Molecules.2016, 21(10)Oncotarget.2016, 8(51):88386-88400Universidade Estadual Paulista...2017...Semyung University2017, 149407Molecules.2017, 22(3)Pharmacol Rep.2017, 69(6):1224-1231Analytical Methods2018, 10(27)J Nat Prod.2018, 81(4):966-975
Analytical methods2019, 11(6)Microb Pathog.2019, 131:128-134Neuropharmacology2019, 151437J Ethnopharmacol.2019, 228:132-141J Mater Chem B.2019, 7(39):5896-5919TCI CO.2019, US20190151257A1Asian Pac J Cancer Prev. ...2020...Int J Mol Sci.2020, 21(9):3392.
J Ethnopharmacol.2020, 269:113752. Int J Mol Med.2020, 45(5):1514-1524.BMB Rep.2020, 53(4):218-222.Biomedicines.2020, 8(11):486.Chem. of Vegetable Raw Materials...2020...Chung Shan Medical University...2020...J Nat Med.2021, doi: 10.1007.
Our products had been exported to the following research institutions and universities, And still growing.
Monash University Malaysia (Malaysia)Worcester Polytechnic Institute (USA)Sant Gadge Baba Amravati Univer... (India)Johannes Gutenberg University M... (Germany)
Centrum Menselijke Erfelijkheid (Belgium)Universiti Putra Malaysia(UPM) (Malaysia)Amity University (India)University of Perugia (Italy)
Korea Institute of Oriental Med... (Korea)Pennsylvania State University (USA)Tohoku University (Japan)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Front Pharmacol.2020, 11:683.Eur Endod J.2020, 5(1):23-27.Nat Prod Sci.2016, 22(2)Free Radic Biol Med.2017, 112:191-199Int J Mol Sci.2017, 19(1)Molecules.2020, 25(15):3353.Biomol Ther (Seoul).2019, 10.4062Oxid Med Cell Longev.2020, 2020:8887251.Cell Physiol Biochem.2017, 43(4):1425-1435J Pharmaceut Biomed2020, 182:113110
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Triterpenoids Compound Library
||Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM.|
|Molecules . 2017 Oct 27;22(11):1829. |
|Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources[Pubmed: 29077044]|
|Stratum corneum tryptic enzyme kallikrein 5 (KLK5) is a serine protease that is involved in the cell renewal and maintenance of the skin barrier function. The excessive activation of KLK5 causes an exacerbation of dermatoses, such as rosacea and atopic dermatitis. Some triterpenoids are reported to suppress the serine proteases. We aimed to investigate whether bioactive triterpenoids modulate the KLK5 protease. Nineteen triterpenoids occurring in medicinal crude drugs were evaluated using an enzymatic assay to measure the anti-KLK5 activity. The KLK5-dependent cathelicidin peptide LL-37 production in human keratinocytes was examined using immunoprecipitation and Western blotting. Screening assays for evaluating the anti-KLK5 activity revealed that ursolic acid, oleanolic acid, saikosaponin b₁, Tumulosic acid and pachymic acid suppressed the KLK5 protease activity, although critical molecular moieties contributing to anti-KLK5 activity were unclarified. Ursolic acid and Tumulosic acid suppressed the proteolytic processing of LL-37 in keratinocytes at ≤10 μM; no cytotoxicity was observed. Both triterpenoids were detected in the plasma of rats administered orally with triterpenoid-rich crude drug Jumihaidokuto. Our study reveals that triterpenoids, such as ursolic acid and Tumulosic acid, modulate the KLK5 protease activity and cathelicidin peptide production. Triterpenoids may affect the skin barrier function via the regulation of proteases.|
Tumulosic acid Description
||The roots of Wolfiporia cocos
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.