8-Hydroxy-ar-turmerone | CAS:949081-09-8

8-Hydroxy-ar-turmerone

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8-Hydroxy-ar-turmerone Description

Source:	The herbs of Kelussia odoratissima.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Drug Des Devel Ther. 2017 Feb 1;11:337-350.

Kelussia odoratissima Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo.[Pubmed: 28203057 ]

The aim of this study was to evaluate the anticancer potential of Kelussia odoratissima. Several in vitro and in vivo biological assays were applied to explore the direct effect of an extract and bioactive compound of this plant against breast cancer cells and its possible mechanism of action.
METHODS AND RESULTS:
K. odoratissima methanol extract (KME) was prepared, and MTT assay was used to evaluate the cytotoxicity. To identify the cytotoxic compound, a bioassay-guided investigation was performed on methanol extract. 8-Hydroxy-ar-turmerone was isolated as a bioactive compound. In vivo study was performed in the breast cancer rat model. LA7 cell line was used to induce the breast tumor. Histopathological and expression changes of PCNA, Bcl-2, Bax, p27 and p21 and caspase-3 were examined. The induction of apoptosis was tested using Annexin V-fluorescein isothiocyanate (FITC) assay. To confirm the intrinsic pathway of apoptosis, caspase-7 and caspase-9 assays were utilized. In addition, cell cycle arrest was evaluated. Our results demonstrated that K. odoratissima has an obvious effect on the arrest of proliferation of cancer cells. It induced apoptosis, transduced the cell death signals, decreased the threshold of mitochondrial membrane potential (MMP), upregulated Bax and downregulated Bcl-2.
CONCLUSIONS:
This study demonstrated that K. odoratissima exhibits antitumor activity against breast cancer cells via cell death and cell cycle arrest.

Product Name	8-Hydroxy-ar-turmerone
Price:
CAS No.:	949081-09-8
Catalog No.:	CFN89227
Molecular Formula:	C₁₅H₂₀O₂
Molecular Weight:	232.32 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Oil
Source:	The herbs of Kelussia odoratissima.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Sesquiterpenoids Compound Library p21 Inhibitor Library MMP(e.g.TIMP) Inhibitor Library Caspase Inhibitor Library Bcl-2/Bax Inhibitor Library

Description:	8-Hydroxy-ar-turmerone may exhibit antitumor activity against breast cancer cells via cell death and cell cycle arrest.
Targets:	p21 \| Bcl-2/Bax \| Caspase \| MMP(e.g.TIMP)

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.3044 mL	21.522 mL	43.0441 mL	86.0882 mL	107.6102 mL
5 mM	0.8609 mL	4.3044 mL	8.6088 mL	17.2176 mL	21.522 mL
10 mM	0.4304 mL	2.1522 mL	4.3044 mL	8.6088 mL	10.761 mL
50 mM	0.0861 mL	0.4304 mL	0.8609 mL	1.7218 mL	2.1522 mL
100 mM	0.043 mL	0.2152 mL	0.4304 mL	0.8609 mL	1.0761 mL

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