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1. Reference standards
2. Pharmacological research
3. Inhibitors
Elgonica dimer A
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $478.4 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Mol Neurobiol.2021, 58(8):3665-3676. Int J Mol Sci.2022, 23(5):2796. Phytomedicine.2015, 22(11):1027-36J Pharmaceutical Research Int....2021...Chem Biol Interact.2020, 328:109200.J Vet Sci.2020, 21(3):e39.Neurotox Res.2022, 40(6):1937-1947. Foods.2021, 10(6):1378.
J Agric Food Chem.2018, 66(1):351-358Pharmacognosy Journal....2020...Front Pharmacol.2021, 12:765521.LWT - Food Science and Technology...2022...J Biol Chem.2014, 289(3):1723-31Food and Fermentation Industries...2019...Int J Mol Sci.2021, 22(12):6466.Int J Mol Sci.2020, 21(8):2790.
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Semmelweis Unicersity (Hungary)Massachusetts General Hospital (USA)Institute of Pathophysiology Me... (Austria)Shanghai University of TCM (China)
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Elgonica dimer A
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ACS Synth Biol.2022, doi: 10.1021.Food Chem.2016, 191:81-90Front Plant Sci.2021, 12: 648426.Biomed Pharmacother.2022, 146:112497.Lab Chip.2018, 18(6):971-978Biomed Pharmacother.2019, 111:262-269Pharmacol Rep.2022, 74(1):175-188.Sci Rep.2019, 9(1):4342Food Chem.2022, 378:131975.J Food Composition and Analysis2022, 104417.
Related Screening Libraries
| In vitro: |
| Yao Xue Xue Bao . 2006 Oct;41(10):1000-1003. | | [Active constituents from Aloe arborescens as BACE inhibitors][Pubmed: 17184120] | | Aim: To seek for new components as BACE inhibitors from Aloe arborescens.
Methods: The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis.
Results: Eight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately.
Conclusion: Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE. |
|
| In vivo: |
| Planta Med . 2001 Nov;67(8):757-760. | | Hypotensive effect of chemical constituents from Aloe barbadensis[Pubmed: 11731923] | | Hypotensive effects of aloeemodin, aloin A, Elgonica dimer A and bisbenzopyran from Aloe barbadensis have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the corresponding doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absolute configuration of Elgonica dimer A (1). |
|
Elgonica dimer A Description
| Source: |
|
| Solvent: |
DMSO, Pyridine, Methanol, Ethanol, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.4565 mL |
7.2823 mL |
14.5645 mL |
29.129 mL |
36.4113 mL |
| 5 mM |
0.2913 mL |
1.4565 mL |
2.9129 mL |
5.8258 mL |
7.2823 mL |
| 10 mM |
0.1456 mL |
0.7282 mL |
1.4565 mL |
2.9129 mL |
3.6411 mL |
| 50 mM |
0.0291 mL |
0.1456 mL |
0.2913 mL |
0.5826 mL |
0.7282 mL |
| 100 mM |
0.0146 mL |
0.0728 mL |
0.1456 mL |
0.2913 mL |
0.3641 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Planta Med . 2001 Nov;67(8):757-760. | | Hypotensive effect of chemical constituents from Aloe barbadensis[Pubmed: 11731923] | | Hypotensive effects of aloeemodin, aloin A, Elgonica dimer A and bisbenzopyran from Aloe barbadensis have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the corresponding doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absolute configuration of Elgonica dimer A (1). | | Yao Xue Xue Bao . 2006 Oct;41(10):1000-1003. | | [Active constituents from Aloe arborescens as BACE inhibitors][Pubmed: 17184120] | | Aim: To seek for new components as BACE inhibitors from Aloe arborescens.
Methods: The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis.
Results: Eight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately.
Conclusion: Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE. |
|
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