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    Natural Products
    Elgonica dimer A
    Elgonica dimer A
    Information
    CAS No. 132210-48-1 Price $368 / 5mg
    Catalog No.CFN95445Purity>95%
    Molecular Weight686.6Type of CompoundAnthraquinones
    FormulaC36H30O14Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $478.4 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Elgonica dimer A

    Elgonica dimer A
    Product Name Elgonica dimer A
    CAS No.: 132210-48-1
    Catalog No.: CFN95445
    Molecular Formula: C36H30O14
    Molecular Weight: 686.6 g/mol
    Purity: >95%
    Type of Compound: Anthraquinones
    Physical Desc.: Powder
    Source:
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $368 / 5mg
    Inquire / Order: manager@chemfaces.com
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  • Food Chem.2017, 228:301-314
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anthraquinones Compound Library
  • Biological Activity
    In vitro:
    Yao Xue Xue Bao . 2006 Oct;41(10):1000-1003.
    [Active constituents from Aloe arborescens as BACE inhibitors][Pubmed: 17184120]
    Aim: To seek for new components as BACE inhibitors from Aloe arborescens. Methods: The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis. Results: Eight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately. Conclusion: Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.
    In vivo:
    Planta Med . 2001 Nov;67(8):757-760.
    Hypotensive effect of chemical constituents from Aloe barbadensis[Pubmed: 11731923]
    Hypotensive effects of aloeemodin, aloin A, Elgonica dimer A and bisbenzopyran from Aloe barbadensis have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the corresponding doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absolute configuration of Elgonica dimer A (1).
    Elgonica dimer A Description
    Source:
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

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    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4565 mL 7.2823 mL 14.5645 mL 29.129 mL 36.4113 mL
    5 mM 0.2913 mL 1.4565 mL 2.9129 mL 5.8258 mL 7.2823 mL
    10 mM 0.1456 mL 0.7282 mL 1.4565 mL 2.9129 mL 3.6411 mL
    50 mM 0.0291 mL 0.1456 mL 0.2913 mL 0.5826 mL 0.7282 mL
    100 mM 0.0146 mL 0.0728 mL 0.1456 mL 0.2913 mL 0.3641 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Planta Med . 2001 Nov;67(8):757-760.
    Hypotensive effect of chemical constituents from Aloe barbadensis[Pubmed: 11731923]
    Hypotensive effects of aloeemodin, aloin A, Elgonica dimer A and bisbenzopyran from Aloe barbadensis have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the corresponding doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absolute configuration of Elgonica dimer A (1).
    Yao Xue Xue Bao . 2006 Oct;41(10):1000-1003.
    [Active constituents from Aloe arborescens as BACE inhibitors][Pubmed: 17184120]
    Aim: To seek for new components as BACE inhibitors from Aloe arborescens. Methods: The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis. Results: Eight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately. Conclusion: Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.
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