| Structure Identification: |
| Planta Med . 2001 Nov;67(8):757-760. | | Hypotensive effect of chemical constituents from Aloe barbadensis[Pubmed: 11731923] | | Hypotensive effects of aloeemodin, aloin A, Elgonica dimer A and bisbenzopyran from Aloe barbadensis have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the corresponding doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absolute configuration of Elgonica dimer A (1). | | Yao Xue Xue Bao . 2006 Oct;41(10):1000-1003. | | [Active constituents from Aloe arborescens as BACE inhibitors][Pubmed: 17184120] | | Aim: To seek for new components as BACE inhibitors from Aloe arborescens.
Methods: The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis.
Results: Eight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately.
Conclusion: Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE. |
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