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    Natural Products
    Phyllanthusiin C
    Phyllanthusiin C
    Information
    CAS No. 142674-52-0 Price $368 / 5mg
    Catalog No.CFN95260Purity>95%
    Molecular Weight926.7Type of CompoundPhenols
    FormulaC40H30O26Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $644.0 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Kazusa DNA Research Institute (Japan)
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  • University of Bonn (Germany)
  • Medical University of Gdansk (Poland)
  • Max-Planck-Insitut (Germany)
  • Fraunhofer-Institut für Moleku... (Germany)
  • MTT Agrifood Research Finland (Finland)
  • University of Medicine and Phar... (Romania)
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    Description: Reference standards.
    In vitro:
    Complementary Medicine Research, 2009.
    Phyllanthus urinaria Increases Apoptosis and Reduces Telomerase Activity in Human Nasopharyngeal Carcinoma Cells.[Reference: WebLink]
    This study was designed to obtain the chemical fingerprint and to investigate the effect of Phyllanthus urinaria on telomerase activity and apoptotic pathways in the human nasopharyngeal carcinoma cell line (NPC-BM1).
    METHODS AND RESULTS:
    The polyphenol compounds in P. urinaria were investigated by HPLC/MS. Cell viability with the treatment of P. urinaria, gallic acid, ellagic acid, quercetin and cisplatin was detected by MTT assay. TUNEL assay, DNA fragmentation analysis and caspase3 activity were used to confirm apoptotic changes. Telomerase activity was determined using the TRAP assay. RNA isolation and RT-PCR were used to analyze the related genes expression. All experiments on treatments with P. urinaria from 0–3 mg/ml were carried out for 24 h. 5 major compounds including gallic acid, brevifolin carboxylic acid, corilagin, Phyllanthusiin C and ellagic acid were identified as a plant fingerprint by HPLC/MS. With the MTT assay, we demonstrated that P. urinaria, gallic acid and ellagic acid reduce cell viability. The apoptosis features showed DNA fragmentation and increased caspase-3 activity associated with the down-regulation of Bcl-2, but not of Bax, p53, and PCNA (proliferating cell nuclear antigen) in P. urinaria-treated NPC-BM1 cells. Furthermore, treatment of NPC-BM1 cells led to an inhibition of hTERT (human telomerase reverse transcriptase), hTP1 (human telomerase-associated protein 1) and c-myc mRNA expression and to decreased telomerase activity.
    CONCLUSIONS:
    This study suggests that P. urinaria induces the death of NPC-BM1 cells in vitro through the induction of apoptosis and inhibited telomerase activity.
    Phyllanthusiin C Description
    Source: The fruits of Terminalia chebula.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0791 mL 5.3955 mL 10.791 mL 21.582 mL 26.9774 mL
    5 mM 0.2158 mL 1.0791 mL 2.1582 mL 4.3164 mL 5.3955 mL
    10 mM 0.1079 mL 0.5395 mL 1.0791 mL 2.1582 mL 2.6977 mL
    50 mM 0.0216 mL 0.1079 mL 0.2158 mL 0.4316 mL 0.5395 mL
    100 mM 0.0108 mL 0.054 mL 0.1079 mL 0.2158 mL 0.2698 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.