Acetoxyisovalerylalkannin | CAS:69091-17-4

Acetoxyisovalerylalkannin

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	Acetoxyisovalerylalkannin
Price:	$138 / 20mg
CAS No.:	69091-17-4
Catalog No.:	CFN92025
Molecular Formula:	C₂₃H₂₆O₈
Molecular Weight:	430.5 g/mol
Purity:	>=98%
Type of Compound:	Quinones
Physical Desc.:	Oil
Source:	The roots of Lithosperraum erythrorhizon Sieb. et Zucc.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / $49.9 / In-stock
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Description:

Acetoxyisovalerylalkannin may have anti-ageing activity, it can upregulate Collagen-I, elastin and involucrin syntheses in human dermal fibroblasts or keratinocytes.

In vitro:

Natural Product Research, 2015, Mar 26,30(5):574-577.

Anti-skin ageing activity of napthoquinones from Arnebia nobilis Reichb.f.[Pubmed: 25810219]

The present isolation and identification of napthoquinones from roots of Arnebia nobilis Reichb.f. can lead to the discovery of new anti-skin ageing ingredient in colour cosmetics.
METHODS AND RESULTS:
Four compounds have been isolated and purified by rigorous column chromatography. The compounds are identified as β, β-dimethylacryl alkannin (AN-I), Acetoxyisovalerylalkannin (AAN-II), acetyl alkannin (AN-III) and alkannin (AN-IV) by interpretation of spectroscopic data. This study is the first to report the isolation of Acetoxyisovaleryl alkannin (AAN-II) from A. nobilis. The IC50 values of the compounds, determined in human skin cells (human dermal fibroblasts and human keratinocytes) and mouse embryonic fibroblasts (NIH3T3) varied significantly among the four alkannins. Among the four compounds, β-acetoxyisovaleryl alkannin (AAN-II) significantly inhibited hydrogen peroxide (H2O2)-induced red blood corpuscle haemolysis and cellular senescence in human dermal fibroblasts. Collagen-I, elastin and involucrin syntheses in human dermal fibroblasts or keratinocytes were up regulated by AAN-II.
CONCLUSIONS:
These results support the potential utility of alkannins as novel anti-ageing ingredients.

Acetoxyisovalerylalkannin Description

Source:	The roots of Lithosperraum erythrorhizon Sieb. et Zucc.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Quinones Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3229 mL	11.6144 mL	23.2288 mL	46.4576 mL	58.072 mL
5 mM	0.4646 mL	2.3229 mL	4.6458 mL	9.2915 mL	11.6144 mL
10 mM	0.2323 mL	1.1614 mL	2.3229 mL	4.6458 mL	5.8072 mL
50 mM	0.0465 mL	0.2323 mL	0.4646 mL	0.9292 mL	1.1614 mL
100 mM	0.0232 mL	0.1161 mL	0.2323 mL	0.4646 mL	0.5807 mL

CFN97403	Lapachol	84-79-7	242.3	C₁₅H₁₄O₃
CFN92024	Deoxyshikonin	43043-74-9	272.3	C₁₆H₁₆O₄
CFN92622	Shikonine	517-89-5	288.3	C₁₆H₁₆O₅
CFN99907	Shikonin	517-88-4	288.31	C₁₆H₁₆O₅
CFN90308	Acetylshikonin	54984-93-9	330.33	C₁₈H₁₈O₆
CFN92023	Isobutylshikonin	52438-12-7	358.4	C₂₀H₂₂O₆
CFN90164	Dimethylacrylshikonin	24502-79-2	370.39	C₂₁H₂₂O₆
CFN90626	Beta,beta-Dimethylacrylalkannin	34539-65-6	370.4	C₂₁H₂₂O₆
CFN95222	Isovalerylshikonin	52387-14-1	372.4	C₂₁H₂₄O₆
CFN93028	Beta-Hydroxyisovalerylshikonin	7415-78-3	388.42	C₂₁H₂₄O₇