ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
How to Order
Orders via your E-mail:
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Mol Med Rep.2014, 9(5):1653-9Oncotarget.2015, 6(31):30831-49J Ethnopharmacol.2016, 192:370-381Molecules.2016, 21(6)Research on Crops.2017, 18(3):569Molecules.2017, 22(11)Phytochemistry Letters2017, 449-455Plant J.2017, 90(3):535-546
Food Res Int.2018, 106:909-919Molecules.2018, 23(7):E1817Biosci Rep.2018, 38(4)Biol Pharm Bull.2018, 41(11):1645-1651Neuropharmacology2019, 151437Chemistry of Plant Materials....2019...Molecules.2019, 24(11):E2044Molecules.2019, 24(16):E2985
Molecules.2019, 24(16):E3003Phytother Res.2019, 33(3):676-689J Ethnopharmacol.2020, 249:112396Crystals2020, 10(3), 206.Biochem Pharmacol.2020, 178:114083Nature Ecology & Evolution...2020...Natural Product Communications...2020...
Our products had been exported to the following research institutions and universities, And still growing.
Aarhus University (Denmark)University of Mysore (India)Universite de Lille1 (France)Georgia Institute of Technology (USA)
Research Unit Molecular Epigene... (Germany)Warszawski Uniwersytet Medyczny (Poland)Chinese University of Hong Kong (China)Siksha O Anusandhan University (India)
University of Zurich (Switzerland)Wroclaw Medical University (Poland)Utrecht University (Netherlands)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Molecules.2019, 24(4):E709Biomol Ther (Seoul).2019, 10.4062Microb Pathog.2019, 131:128-134BioResources J.2020, 15(3).Molecules.2020, 25(17):3783.Molecular & Cellular Toxicology2017, 13(3):271-278Food Chem.2019, 275:746-753Chemistry of Natural Compounds2018, 54(3):572–576Analytical Methods2018, 10(27)Nutrients.2018, 10(12):E1998
Related Screening Libraries
||Aflavarin exhibits potent antifeedant activity against the fungivorous beetle Carpophilus hemipterus. |
|Fungal Genet Biol. 2017 Jul;104:29-37. |
|Aspergillus flavus aswA, a gene homolog of Aspergillus nidulans oefC, regulates sclerotial development and biosynthesis of sclerotium-associated secondary metabolites.[Pubmed: 28442441]|
METHODS AND RESULTS:
Aspergillus flavus aswA (AFLA_085170) is a gene encoding a Zn(II)2Cys6 DNA-binding domain and a transcriptional activation domain, DUF3468. Disruption of aswA yielded strains that made a truncated gene transcript and generated a fungus that produced a greatly increased number of sclerotia. These sclerotia were odd-shaped and non-pigmented (white) and different from oval and pigmented (dark brown to black) mature sclerotia. Transcriptomic analysis of the ΔaswA strain grown on potato dextrose agar plates and Wickerham agar plates showed that expression of clustering genes involved in the biosynthesis of three sclerotium-associated secondary metabolites was down-regulated. These included gene clusters of asparasone, aflatrem, and Aflavarin. In contrast, those of aflatoxin, cyclopiazonic acid and kojic acid were not affected.
Metabolite analyses confirmed that the non-pigmented sclerotia contained aflatoxin and cyclopiazonic acid but not other aforementioned metabolites, three asparasone analogs and dihydroxyaflavinine commonly present in mature sclerotia. Impairment in aswA gene function stalls normal sclerotial development, which in turn prevents biosynthesis and accumulation of sclerotium-specific metabolites.
|Journal of Natural Products, 1992, 55(8):1080-1086. |
|Aflavarin and β-Aflatrem: New Anti-Insectan Metabolites from the Sclerotia of Aspergillus flavus[Reference: WebLink]|
METHODS AND RESULTS:
Aflavarin , a new bicoumarin, and beta-aflatrem , an isomer of the tremorgen aflatrem, were isolated from the sclerotia of Aspergillus flavus. The structures were determined through a series of 1D and 2D nmr experiments, assisted by spectral comparisons with known compounds. Aflavarin exhibits potent antifeedant activity against the fungivorous beetle Carpophilus hemipterus. Beta-aflatrem causes a significant reduction in the growth rate of the corn earworm Helicoverpa zea.
The presence of nominine  as a minor metabolite of A. flavus is reported for the first time.
||The secondary metabolites of Aspergillus flavus
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.