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1. Reference standards
2. Pharmacological research
3. Inhibitors
Alopecurone A
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock |
10 mM * 1 mL in DMSO / $251.2 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Phytomedicine.2022, 110:154597.Appl. Sci. 2021, 11(17),7829Pharmaceuticals (Basel)....2022...J Pharmaceutical and Biomedical A...2022...J Sep Sci.2018, 41(11):2488-2497Plant Pathology2022, 10.1111:ppa.13651.Biomedicines.2021, 9(8):996.Oncotarget.2017, 8(64):108006-108019
J Int Med Res....2021...Pharmaceuticals (Basel)....2020...J Pharmacol Sci.2021, 147(2):184-191.Chem Biol Interact.2016, 260:168-175Molecules 2022, 27(3),1047.Drug Des Devel Ther.2020, 14:969-976.BMC Complement Altern Med....2019...Plant J.2021, 107(6):1711-1723.
Antioxidants (Basel)....2022...Pharmacognosy Magazine...2017...Molecular & Cellular Toxicology...2017...J of Physics Conference Series...2019...Cell.2018, 172(1-2):249-261SBRAS2016, 12Journal of Plant Growth Regulatio...2022...
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Our products had been exported to the following research institutions and universities, And still growing.
Universita' Degli Studi Di Cagl... (Italy)Universidad de Antioquia (Colombia)Heidelberg University (Germany)Istanbul University (Turkey)
University of Queensland (Australia)Seoul National University of Sc... (Korea)Aveiro University (Portugal)Universidade Federal de Santa C... (Brazil)
University of British Columbia (Canada)Utah State University (USA)University of Auckland (New Zealand)
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Alopecurone A
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manager@chemfaces.com
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J AOAC Int.2021, 104(6):1634-1651.Int J Mol Sci.2022, 23(23):14545.J Pharm Biomed Anal.2019, 164:119-127Plant Biotechnology Reports 2021, 15:117-124.Antioxidants (Basel).2019, 8(8):E307Pharmacognosy Magazine2018, 14(56):418-424J Applied Biological Chemistry2021, 64(2):185-192Molecules2022, 27(11):3606.Phytomedicine.2018, 47:48-57The Korea Journal of Herbology2020, 35(3):33-45.
Related Screening Libraries
Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Flavonoids Compound Library |
Description: |
Alopecurone A exhibits potent inhibitory activity on MRP1.Alopecurone A exhibits cytotoxic activity in DU145 (prostate cancer cell line) and MCF-7 (breast cancer cell line) cell lines with IC50 values of 2.44 and 5.44 μg/mL. respectively.Alopecurone A has antibacterial activity against methicillin-resistant Staphylococcus aureus. |
In vitro: |
Nat Prod Res. 2014;28(23):2195-2198. | Flavonostilbenes from Sophora alopecuroides L. as multidrug resistance associated protein 1 (MRP1) inhibitors[Pubmed: 24956120] | Flavonoids have always attracted much attention due to their reversal activity on multidrug resistance (MDR). Eight flavonoids isolated from traditional Chinese medicine Sophora alopecuroides L. were applied to test their effect on MDR associated protein 1 (MRP1) through the established predicting assay. Three flavonostilbenes (Alopecurone A, B and D) were first found exhibiting potent inhibitory activity on MRP1. All of them dramatically increased 6-carboxyfluorescein diacetate and doxorubicin accumulation in MRP1-transfected U-2 OS cells. The compounds significantly increased the cytotoxicity and decreased the IC₅₀ value of doxorubicin on the MDR cells (12-, 5- and 8-fold, respectively) at a non-toxic concentration (20 μM). Besides, Q-PCR analysis reveals that the MRP1 mRNA level in U-2 OS/MRP1 was also markedly decreased by the three compounds. These findings indicate a new therapeutic role of the herb. The three flavonostilbenes may have the possibility for further development as novel therapeutic reversal agents against MDR. | Lett Appl Microbiol. 1995 Oct;21(4):219-222. | Antibacterial activity of flavanostilbenes against methicillin-resistant Staphylococcus aureus[Pubmed: 7576511] | Three phytochemical compounds (Alopecurone A-C), flavanostilbenes which are produced by condensation between a hydroxyflavanone and a hydroxystilbene, were isolated as major components from the root of Sophora alopecuroides. They uniformly inhibited the growth of 21 strains of methicillin-resistant Staphylococcus aureus with minimum inhibitory concentrations of 3.13-6.25 micrograms ml-1. |
|
Alopecurone A Description
Source: |
The herbs of Sophora alopecuroides |
Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
1.5368 mL |
7.684 mL |
15.3681 mL |
30.7361 mL |
38.4202 mL |
5 mM |
0.3074 mL |
1.5368 mL |
3.0736 mL |
6.1472 mL |
7.684 mL |
10 mM |
0.1537 mL |
0.7684 mL |
1.5368 mL |
3.0736 mL |
3.842 mL |
50 mM |
0.0307 mL |
0.1537 mL |
0.3074 mL |
0.6147 mL |
0.7684 mL |
100 mM |
0.0154 mL |
0.0768 mL |
0.1537 mL |
0.3074 mL |
0.3842 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Cell Research: |
Nat Prod Res . 2017 Jun;31(11):1270-1276. | Dereplication of cytotoxic compounds from different parts of Sophora pachycarpa using an integrated method of HPLC, LC-MS and 1 H-NMR techniques[Pubmed: 27696895] | Sophora pachycarpa Schrenk ex C.A.Mey. is an annual plant belonging to the family Fabaceae. The cytotoxic activities of methanol-dichloromethane extracts (1:1) of different parts of S. pachycarpa were investigated on DU145 (prostate cancer cell line) and MCF-7 (breast cancer cell line) cell lines. The root extract of S. pachycarpa was the only extract that showed significant cytotoxic activity with IC50 values of 39.88 and 16.49 μg/mL on DU145 and MCF-7 cell lines, respectively. The root extract was then subjected to RP-HPLC for further fractionations. Among the isolated fractions from root extract, only one of them had remarkable cytotoxic effects with IC50 value of 26.43 on MCF-7 and 7.54 μg/mL on DU145 cell lines. Further purification led to isolation of a compound with IC50 values of 5.44 and 2.44 μg/mL on MCF-7 and DU145 cell lines, respectively. Based on 1H NMR and 13C NMR spectra, together with LC-MS, the structure of the purified compound was assigned as the flavonostilbene Alopecurone A. |
|
Structure Identification: |
Nat Prod Res . 2017 Jun;31(11):1270-1276. | Dereplication of cytotoxic compounds from different parts of Sophora pachycarpa using an integrated method of HPLC, LC-MS and 1 H-NMR techniques[Pubmed: 27696895] | Sophora pachycarpa Schrenk ex C.A.Mey. is an annual plant belonging to the family Fabaceae. The cytotoxic activities of methanol-dichloromethane extracts (1:1) of different parts of S. pachycarpa were investigated on DU145 (prostate cancer cell line) and MCF-7 (breast cancer cell line) cell lines. The root extract of S. pachycarpa was the only extract that showed significant cytotoxic activity with IC50 values of 39.88 and 16.49 μg/mL on DU145 and MCF-7 cell lines, respectively. The root extract was then subjected to RP-HPLC for further fractionations. Among the isolated fractions from root extract, only one of them had remarkable cytotoxic effects with IC50 value of 26.43 on MCF-7 and 7.54 μg/mL on DU145 cell lines. Further purification led to isolation of a compound with IC50 values of 5.44 and 2.44 μg/mL on MCF-7 and DU145 cell lines, respectively. Based on 1H NMR and 13C NMR spectra, together with LC-MS, the structure of the purified compound was assigned as the flavonostilbene Alopecurone A. |
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