ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $206.7 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Asian Journal of Chemistry...2014...The Korea Society of Pha.2014, 300-314J Breast Cancer.2015, 18(2):112-118Int J Mol Med.2016, 37(2):501-8Journal of Life Science2017, 233-240Yakugaku Zasshi.2018, 138(4):571-579Integr Cancer Ther.2018, 17(3):832-843Molecules.2018, 23(2)
Chemistry of Natural Compounds...2018...Phytother Res.2019, 10.1002Nutrients.2019, 11(4):E936Nutrients.2019, 11(6):E1380Exp Ther Med.2019, 18(6):4388-4396Molecules.2019, 24(20):3755Appl Biol Chem2019, 62:46Drug Des Devel Ther.2020, 14:61-71
Molecules2020, 25(4):892BMC Plant Biol.2020, 20(1):214. Int J Mol Sci.2020, 21(7):2530.Korean J of Pharmacognosy...2020...J of Applied Biological Chem....2020...Natural Product Communications...2020...Separations2021, 8(1), 1.
Our products had been exported to the following research institutions and universities, And still growing.
Amity University (India)University of Hawaii Cancer Center (USA)University of Wisconsin-Madison (USA)Aveiro University (Portugal)
Ateneo de Manila University (Philippines)Agricultural Research Organizat... (Israel)University of Fribourg (Switzerland)Uniwersytet Gdański (Poland)
Kazusa DNA Research Institute (Japan)University of Stirling (United Kingdom)Chungnam National University (Korea)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Molecules.2019, 24(2):329J Asian Nat Prod Res.2019, 5:1-17J of the Korean Society of Cosmetics and Cosmetology2019, 225-231J Nat Sc Biol Med2019, 10(2):149-156Dent Mater J.2020, 39(4):690-695Korean J Dent Mater.2018, 45(2):139-146Natural Product Communications2020, doi: 10.1177.Adaptive Medicine 2020, 12(1): 4-10Journal of Life Science2018, 917-922Biol Pharm Bull.2020, 43(10):1534-1541.
Related Screening Libraries
||Apigenin 5-O-beta-D-glucopyranoside has inhibitory activity against the enzyme yeast a-glucosidase, withthe IC50 value of 287.12 muM.|
|Phytotherapy Research. 2006 July;20(7):610–613. |
|Isolation of flavonoids, a biscoumarin and an amide from the flower buds of Daphne genkwa and the evaluation of their anti-complement activity[Reference: WebLink]|
|As part of an ongoing study aimed at identifying the anti-complement active compound from the flower buds of Daphne genkwa, ten flavonoids, one biscoumarin and one amide were isolated.
METHODS AND RESULTS:
Their structures were identified from spectroscopic and physicochemical data as genkwanin 5-O-β-d-primveroside (1), apigenin 7-O-β-d-glucuronide (2), genkwanin 5-O-β-d-glucopyranoside (3), Apigenin 5-O-beta-D-glucopyranoside (4), genkwanin (5), apigenin (6), luteolin 7-methyl ether (7), luteolin (8), daphnoretin (9), velutin (10), 7-methoxyacacetin (11) and aurantiamide acetate (12). Among them, compounds 9, 10 and 12 were isolated from this plant for the first time. The anti-complement activity of these compounds was tested against the classical pathway of the complement system.
Among the compounds, daphnoretin (9) exhibited significant anti-complement activity with an IC50 value of 11.4 µm, whereas the other compounds were not active in the assay.
Apigenin 5-O-beta-D-glucopyranoside Description
||The herbs of Scutellaria barbata
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Phytochem. Lett., 2013, 6(4):614-9. |
|α-Glucosidase inhibitory constituents from Chrozophora plicata[Reference: WebLink]|
METHODS AND RESULTS:
Five new secondary metabolites have been isolated from Chrozophora plicata including an acacetin derivative (1), three pyrrole alkaloids plicatanins A–C (2-4 resp) and the bilactone plicatanone (5). Together with these compounds, the known compounds, β-sitosterol (6), methyl p-coumarate (7), 4-hydroxyphenylacetic acid (8), succinic acid (9), speranberculatine A (10), β-sitosterol-3-O-β- d -glucopyranoside (11) and a Apigenin 5-O-beta-D-glucopyranoside (12) have also been isolated. The structures of isolates 1-12 were established by 1D (1 H,13 C) and 2D NMR (HMQC, HMBC, COSY) spectroscopy and mass spectrometry (EIMS, HREIMS, FABMS, HRFABMS). The structure of plicatanin A (3) was further confirmed through single crystal X-ray technique. Compounds 1-12 were evaluated for their inhibitory activity against the enzyme yeast α -glucosidase.
The compound 4 was found to be most potent with IC 50 value 27.802uM.