Aristolactam AII | CAS:53948-07-5 | Manufacturer ChemFaces

Aristolactam AII

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Product Name	Aristolactam AII
Price:
CAS No.:	53948-07-5
Catalog No.:	CFN96013
Molecular Formula:	C₁₆H₁₁NO₃
Molecular Weight:	265.3 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Yellow powder
Source:	The herbs of Aristolochia debilis Sieb. et Zucc
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.

Targets:

PAFR

In vitro:

Phytochemistry. 2013 Feb;86:121-6.

Pyridocoumarin, aristolactam and aporphine alkaloids from the Australian rainforest plant Goniothalamus australis.[Pubmed: 23158725]

METHODS AND RESULTS:
Chemical investigation of the CH(2)Cl(2)/CH(3)OH extracts from aerial parts of the Australian plant Goniothalamus australis has resulted in the isolation of two pyridocoumarin alkaloids, goniothalines A (1) and B (2) as well as eight known natural products, Aristolactam AII (3), enterocarpam II (4), caldensine (5), sauristolactam (6), (-)-anonaine (7), asimilobine (8), altholactone (9) and ( )-goniofufurone (10). The chemical structures of all compounds were determined by extensive spectroscopic and spectrometric analysis. Methylation of 2 using TMS-diazomethane afforded 1, which unequivocally established that both 1 and 2 possessed a 10-methyl-2H-pyrano[2,3-f]quinolin-2-one skeleton. These pyridocoumarin alkaloids are putatively proposed to arise biosynthetically from an aporphinoid precursor. Compounds 1-10 were evaluated for in vitro antimalarial activity against a chloroquine-sensitive Plasmodium falciparum line (3D7).
CONCLUSIONS:
Sauristolactam (6) and (-)-anonaine (7) exhibited the most potent antiparasitic activity with IC(50) values of 9 and 7 μM, respectively.

Aristolactam AII Description

Source:	The herbs of Aristolochia debilis Sieb. et Zucc
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Antibacterial Compound Library Alkaloids Compound Library PAFR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.7693 mL	18.8466 mL	37.6932 mL	75.3864 mL	94.2329 mL
5 mM	0.7539 mL	3.7693 mL	7.5386 mL	15.0773 mL	18.8466 mL
10 mM	0.3769 mL	1.8847 mL	3.7693 mL	7.5386 mL	9.4233 mL
50 mM	0.0754 mL	0.3769 mL	0.7539 mL	1.5077 mL	1.8847 mL
100 mM	0.0377 mL	0.1885 mL	0.3769 mL	0.7539 mL	0.9423 mL

CFN97551	Aristolactam AIIIa	97399-91-2	281.3	C₁₆H₁₁NO₄
CFN98903	Aristolactam BII	53948-09-7	279.3	C₁₇H₁₃NO₃
CFN98904	Aristolactam BIII	53948-10-0	309.3	C₁₈H₁₅NO₄
CFN97948	Piperolactam C	116064-76-7	309.3	C₁₈H₁₅NO₄
CFN99222	Aristolactam FI	112501-42-5	265.3	C₁₆H₁₁NO₃
CFN96013	Aristolactam AII	53948-07-5	265.3	C₁₆H₁₁NO₃
CFN97866	Griffithinam	240122-32-1	295.3	C₁₇H₁₃NO₄
CFN91875	Aristololactam II	55610-00-9	263.25	C₁₆H₉NO₃
CFN90312	Aristololactam I	13395-02-3	293.27	C₁₇H₁₁NO₄
CFN90417	7-(2'-Deoxyadenosin-N6-yl)aristolactam I	127191-86-0	542.5	C₂₇H₂₂N₆O₇