Aristolactam AIIIa | CAS:97399-91-2 | Manufacturer ChemFaces

Aristolactam AIIIa

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Product Name	Aristolactam AIIIa
Price:
CAS No.:	97399-91-2
Catalog No.:	CFN97551
Molecular Formula:	C₁₆H₁₁NO₄
Molecular Weight:	281.3 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Yellow powder
Source:	The herbs of Aristolochia debilis Sieb. et Zucc.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of platelet aggregation induced by collagen or arachidonic acid.

Targets:

CDK | MAPK

In vitro:

Acta Pharmacol Sin. 2009 Oct;30(10):1443-53.

The natural product Aristolactam AIIIa as a new ligand targeting the polo-box domain of polo-like kinase 1 potently inhibits cancer cell proliferation.[Pubmed: 19801998]

METHODS AND RESULTS:
Aristolactam AIIIa was identified as a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD) which is another efficient tactic for exploring Plk1 inhibitors. Further studies indicated that it could block the proliferations of HeLa, A549, HGC and the HCT-8/V cells (clinical Navelbine-resistant cancer cell), induce mitotic arrest of HeLa cells at G2/M phase with spindle abnormalities and promote apoptosis in HeLa cells. The results from SPR and yeast two-hybrid technology-based assays suggested that it could target both the catalytic domain of Plk1 (CD) and PBD and enhance the CD/PBD interaction.
CONCLUSIONS:
Our current work is expected to shed light on the potential anti-tumor mechanism of Aristolactam AIIIa, and this natural product might be possibly used as a lead compound for further developing anti-tumor drugs.

Aristolactam AIIIa Description

Source:	The herbs of Aristolochia debilis Sieb. et Zucc.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Inhibitors Compound Library Anti-platelet aggregation Compound Library Alkaloids Compound Library MAPK Inhibitor Library CDK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5549 mL	17.7746 mL	35.5492 mL	71.0985 mL	88.8731 mL
5 mM	0.711 mL	3.5549 mL	7.1098 mL	14.2197 mL	17.7746 mL
10 mM	0.3555 mL	1.7775 mL	3.5549 mL	7.1098 mL	8.8873 mL
50 mM	0.0711 mL	0.3555 mL	0.711 mL	1.422 mL	1.7775 mL
100 mM	0.0355 mL	0.1777 mL	0.3555 mL	0.711 mL	0.8887 mL

CFN97551	Aristolactam AIIIa	97399-91-2	281.3	C₁₆H₁₁NO₄
CFN98903	Aristolactam BII	53948-09-7	279.3	C₁₇H₁₃NO₃
CFN98904	Aristolactam BIII	53948-10-0	309.3	C₁₈H₁₅NO₄
CFN97948	Piperolactam C	116064-76-7	309.3	C₁₈H₁₅NO₄
CFN99222	Aristolactam FI	112501-42-5	265.3	C₁₆H₁₁NO₃
CFN96013	Aristolactam AII	53948-07-5	265.3	C₁₆H₁₁NO₃
CFN97866	Griffithinam	240122-32-1	295.3	C₁₇H₁₃NO₄
CFN91875	Aristololactam II	55610-00-9	263.25	C₁₆H₉NO₃
CFN90312	Aristololactam I	13395-02-3	293.27	C₁₇H₁₁NO₄
CFN90417	7-(2'-Deoxyadenosin-N6-yl)aristolactam I	127191-86-0	542.5	C₂₇H₂₂N₆O₇