ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
3. Inhibitors
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $34.9 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Korean Journal of Pharmacognosy...2019...Molecules.2019, 24(20):3755Postharvest Biol Tec2019, 149:18-26iScience.2020, 23(2):100849.Biorxiv2019, 10.1101J Breast Cancer.2015, 18(2):112-118Plants (Basel).2021, 10(12):2795.Molecules.2020, 25(7):1625.
Cell Metab.2020, S1550-4131(20)30002-4J Enzyme Inhib Med Chem....2019...JPC-Journal of Planar Chromatogra...2017...Processes 2021, 9(5),894.Food and Fermentation Industries...2018...Korean J of Food Science&Technolo...2017...Process Biochemistry2019, 87:213-220Korean J of Pharmacognosy...2020...
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National Chung Hsing University (Taiwan)Istanbul University (Turkey)Semmelweis Unicersity (Hungary)
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Arteannuin B
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manager@chemfaces.com
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service@chemfaces.com
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+86-27-84254680
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Molecules.2020, 25(3):734Chem Biol Interact.2018, 283:59-74Phytother Res.2020, 34(4):788-795.Functional Ecology2020, doi: 10.1111.Food Sci Biotechnol.2021, 30(2):217-226.Front Pharmacol.2019, 10:1025Appl. Sci.2021, 11(19),9343.Int J Mol Sci.2019, 20(16):E4015J Control Release.2021, 336:159-168. Biosci Biotechnol Biochem.2021, 85(10):2153-2160.
Related Screening Libraries
| Description: |
Arteannuin B and artemisinic acid are biogenetic precursors of artemisinin, an important antimalarial produced by the herb Artemisia annua, they are active against different bacteria and certain fungal species. Arteannuin B has potential antimalarialand antitumor activity. |
| Targets: |
Antifection |
| In vitro: |
| Yao Xue Xue Bao. 1992;27(4):317-20. | | Derivatives of arteannuin B with antileukemia activity[Pubmed: 1442049] |
METHODS AND RESULTS:
Arteannuin B (I) was converted to hydroxy lactones (VII, VIII) by a mixture of formic acid and sulfuric acid. Compound VI and Compound VII both showed activity against leukemia P 388 cell in vitro. The rate of growth inhibition were 97.5% and 11.8% for (VI) and 80% and 52.6% for (VII) at the concentration of 10 and 1 micrograms/ml respectively.
CONCLUSIONS:
It seems that the antileukemia activity of 6-membered lactone is higher than that of 5-membered and the methylene group is necessary for the antileukemia activity. | | Current Science, 2000 , 78 (6) :709-713. | | Antimicrobial activity of artemisinin and its precursors.[Reference: WebLink] | Artemisinic acid and Arteannuin B are biogenetic precursors of artemisinin, an important antimalarial produced by the herb Artemisia annua. These compounds have been screened for antimicrobial activity against a range of organisms.
CONCLUSIONS:
All the three compounds are active against different bacteria and certain fungal species. |
|
Arteannuin B Description
| Source: |
The herbs of Artemisia annua |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
4.0274 mL |
20.1369 mL |
40.2739 mL |
80.5477 mL |
100.6847 mL |
| 5 mM |
0.8055 mL |
4.0274 mL |
8.0548 mL |
16.1095 mL |
20.1369 mL |
| 10 mM |
0.4027 mL |
2.0137 mL |
4.0274 mL |
8.0548 mL |
10.0685 mL |
| 50 mM |
0.0805 mL |
0.4027 mL |
0.8055 mL |
1.611 mL |
2.0137 mL |
| 100 mM |
0.0403 mL |
0.2014 mL |
0.4027 mL |
0.8055 mL |
1.0068 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| J Sep Sci. 2005 Nov;28(17):2288-92. | | Simultaneous densitometric determination of artemisinin, artemisinic acid and arteannuin-B in Artemisia annua using reversed-phase thin layer chromatography.[Pubmed: 16342793] |
METHODS AND RESULTS:
A rapid and simple RP-TLC method for simultaneous quantification of pharmacologically important sesquiterpene artemisinin (AM) together with its precursors Arteannuin B (AB) and artemisinic acid (AA) in the inflorescence part of Artemisia annua plant has been developed. The RP-TLC of sesquiterpenes was performed on RP-18 F254 S thin-layer chromatographic plates by developing in mobile phase, containing 0.2% TFA in water/ACN (35:65, v/v). The densitometric determination of AM, AB and AA was carried out after derivatization with anisaldehyde reagent at 426 nm in absorption-reflectance mode. | | J Nat Prod. 1993 Sep;56(9):1559-66. | | Bioconversion of arteannuin B to artemisinin.[Pubmed: 8254350] | | Arteannuin B, which co-occurs with artemisinin, the potent antimalarial principle of the Chinese medicinal herb Artemisia annua (Asteraceae), has been converted to the latter using crude and semi-purified cell-free extracts of the leaf homogenates of the plant. Detection procedures to quantitate this bioconversion, including one that is novel which uses gcms, are detailed. | | 8. IUPAC symposium on organometallic chemistry directed towards organic synthesis, Santa Barbara, CA (United States), 6-10 Aug 1995. | | Samarium(II) induced asymmetric reductive cyclizations: The total synthesis of (-)-C{sub 10} desmethyl arteannuin B[Reference: WebLink] | Arteannuin B is a member of the qinghaosu family, a novel class of sesquiterpenes that exhibit powerful antimalarial activity even against chloroquinine resistant strains. It is readily convertible to qinghaosu in several high yielding steps and has potential antitumor activity. Several approaches to the construction of the cis-decalin backbone have involved the use of electrochemical and metal promoted reductions as well as alkylations.
METHODS AND RESULTS:
We report a short convenient total synthesis of (-)-C{sub 10} desmethyl Arteannuin B utilizing an asymmetric reductive cyclization with samarium (II) iodide which selectively forms the cis-decalin ring structure while setting the trans relationship between the subunits of the {gamma}-hydroxy ester. |
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