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    Neochamaejasmine B
    Neochamaejasmine B
    Information
    CAS No. 90411-12-4 Price $418 / 5mg
    Catalog No.CFN92152Purity>=98%
    Molecular Weight542.5Type of CompoundFlavonoids
    FormulaC30H22O10Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $365.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Neochamaejasmine B

    Neochamaejasmine B
    Product Name Neochamaejasmine B
    CAS No.: 90411-12-4
    Catalog No.: CFN92152
    Molecular Formula: C30H22O10
    Molecular Weight: 542.5 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Targets: Antifection
    Source: The roots of Stellera chamaejasme Linn.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $418 / 5mg
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  • Molecules.2019, 24(22):E4022
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • BMC Complement Altern Med.2018, 18(1):221
  • Molecules. 2013, 18(7):7376-88
  • The Korea Journal of Herbology2020, 35(3):33-45.
  • Environ Toxicol.2019, 34(12):1354-1362
  • Mol Med Rep.2014, 9(5):1653-9
  • Invest New Drugs.2017, 35(2):166-179
  • Preprints2017, 2017120176
  • Chem Biol Interact.2016, 258:59-68
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antibacterial Compound Library
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  • Biological Activity
    Description: Neochamaejasmine B displays nematicidal activity against both Bursaphelenchus xylophilus and Bursaphelenchus mucronatus. It can reduce seedling growth and disrupt root development, the IC50 value of 6.9 ug/mL . Neochamaejasmine B has antibacterial activity on Gram-positive bacterium and Gram-negative bacterium.
    Targets: Antifection
    In vitro:
    Phytochemistry. 2014 Oct;106:61-8.
    Phytotoxic flavonoids from roots of Stellera chamaejasme L. (Thymelaeaceae).[Pubmed: 25096753 ]
    Allelopathy, the negative effect on plants of chemicals released to the surroundings by a neighboring plant, is an important factor which contributes to the spread of some weeds in plant communities.
    METHODS AND RESULTS:
    In this field, Stellera chamaejasme L. (Thymelaeaceae) is one of the most toxic and ecologically-threatening weeds in some of the grasslands of north and west China. Bioassay-guided fractionation of root extracts of this plant led to the isolation of eight flavonoids 1-8, whose structures were elucidated by spectroscopic analysis. All compounds obtained, except 7-methoxylneochaejasmin A (4) and (+)-epiafzelechin (5), showed strong phytotoxic activity against Arabidopsis thaliana seedlings. Seedling growth was reduced by neochamaejasmin B (Neochamaejasmine B,1), mesoneochamaejasmin A (2), chamaejasmenin C (3), genkwanol A (6), daphnodorin B (7) and dihydrodaphnodorin B (8) with IC50 values of 6.9, 12.1, 43.2, 74.8, 7.1 and 27.3ug/mL, respectively, and all of these compounds disrupted root development.
    CONCLUSIONS:
    Endogenous auxin levels at the root tips of the A. thaliana DR5::GUS transgenic line were largely reduced by compounds 1, 2 and 6-8, and were increased by compound 4. Moreover, the inhibition rate of A. thaliana auxin transport mutants pin2 and aux1-7 by compounds 1-8 were all lower than the wild type (Col-0).
    Natural Product Research & Development, 2014 , 26 (5) :639-44.
    Nematicidal Activities of Isoneochamaejasmin A and Neochamaejasmin B from the Roots of Stellera chamaejasme L.against Bursaphelenchus xylophilus and Bursaphelenchus mucronatus[Reference: WebLink]
    Two biflavonoids were isolated from ethanol extract from the roots of Stellera chamaejasme L.,and their chemical structures were identified as isoneochamaejasmin A and neochamaejasmin B(Neochamaejasmine B) by nuclear magnetic resonance spectral data.
    METHODS AND RESULTS:
    The nematicidal activities of the two compounds were tested by bioassay methods with second-stage juveniles(J2s)of Bursaphelenchus xylophilus and Bursaphelenchus mucronatus. The results showed these two biflavonoids exhibited significantly nematicidal activities against both B. xylophilus and B. mucronatus. Neochamaejasmin B (Neochamaejasmine B)displayed better nematicidal activity than isoneochamaejasmin A against two species nematodes under the same conditions.
    Neochamaejasmine B Description
    Source: The roots of Stellera chamaejasme Linn.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8433 mL 9.2166 mL 18.4332 mL 36.8664 mL 46.0829 mL
    5 mM 0.3687 mL 1.8433 mL 3.6866 mL 7.3733 mL 9.2166 mL
    10 mM 0.1843 mL 0.9217 mL 1.8433 mL 3.6866 mL 4.6083 mL
    50 mM 0.0369 mL 0.1843 mL 0.3687 mL 0.7373 mL 0.9217 mL
    100 mM 0.0184 mL 0.0922 mL 0.1843 mL 0.3687 mL 0.4608 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Journal of Northwest A & F University, 2008 , 36 (5) :179-184.
    Further study on relationship between structure and antibacterial activity of neochamaejasmine B[Reference: WebLink]
    It further studied the relationship between structure and antibacterial activity of Neochamaejasmine B.
    METHODS AND RESULTS:
    Four compounds,7''-methoxy Neochamaejasmine B(A2-1),7,7''-dimethoxy Neochamaejasmine B(E3),7,7'',4-trimethoxy Neochamaejasmine B(E1) and 4-methylene Neochamaejasmine B(D3) were prepared from Neochamaejasmine B.Their structures were confirmed by ESI-MS,1H NMR and 13C NMR.The antibacterial activity of Neochamaejasmine B and its four derivatives were tested with dish diffusion of Neo-Sensitab in vitro against S.aureas,S.agalactiae,E.coli and Samonellal. The results showed that the antibacterial activity of four derivatives against all bacteria tested was lower than that of Neochamaejasmine B.The antibacterial activity of A2-1,E3 and E1 against Samonellal disappeared at 0.625-5 mg/mL.But the order of the antibacterial activity of all compounds against other bacteria was n-B=D3A2-1E3E1.
    CONCLUSIONS:
    The above mentioned structure-activity relationship studies showed that 7-OH and 7''-OH of Neochamaejasmine B were the main active groups,and that 4'-OH and 4-OH had less contribution to its antibacterial activity,and that carbonyl group was not the main active group.
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