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|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Molecules.2015, 20(10):19172-88J Chromatogr Sci.2015, 53(5):824-9Free Radic Biol Med.2016, 97:307-319Phytochemistry.2017, 141:162-170Evid Based Complement Alternat Me...2017...Korean J of Food Science&Technolo...2017...Mol Cell.2017, 68(4):673-685BMC Plant Biol.2018, 18(1):122
The Journal of Agromedicine and M...2018...Phytomedicine.2018, 40:37-47Anal Bioanal Chem....2018...Planta Med.2018, 84(15):1101-1109Front Pharmacol.2019, 10:1226Chemistry of Vegetable Raw Materi...2019...J of the Korean Society of Food S...2019...Int J Immunopathol Pharmacol....2019...
Advances in Traditional Medicine...2020...Metabolites.2020, 11(1):E11.BMC Complement Med Ther. ...2020...Int J Mol Sci.2020, 21(19),7070.J Cell Mol Med....2020...Medicina (Kaunas).2020, 56(12):685.Drug Dev Res.2020, doi: 10.1002
Our products had been exported to the following research institutions and universities, And still growing.
Stanford University (USA)Universidad Miguel Hernández (Spain)University of Otago (New Zealand)Macau University of Science and... (China)
Kyushu University (Japan)Kazusa DNA Research Institute (Japan)Universite Libre de Bruxelles (Belgium)Aarhus University (Denmark)
Universitas Airlangga (Indonesia)University of Brasilia (Brazil)Chang Gung University (Taiwan)
Related Screening Libraries
||Axillaridine A is a new cholinesterase inhibitors, it may act as potential leads in the discovery of clinically useful inhibitors for nervous-system disorders, particularly by reducing memory deficiency in Alzheimer’s disease patients by potentiating and effecting the cholinergic transmission process. (+)-Axillaridine A has significant activity as antiestrogen binding site (AEBS)-inhibitory agents. |
|J Nat Prod. 1998 Oct;61(10):1257-62. |
|Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens.[Pubmed: 9784163]|
METHODS AND RESULTS:
Four novel steroidal alkaloids, (+)-(20S)-20-(dimethylamino)-3-(3'alpha-isopropyl)-lactam-5alpha-+ ++preg n-2-en-4-one (1), (+)-(20S)-20-(dimethylamino)-16alpha-hydroxy-3-(3'alpha-isopropyl) -la ctam-5alpha-pregn-2-en-4-one (2), (+)-(20S)-3-(benzoylamino)-20-(dimethylamino)-5alpha-pregn-2-en-++ +4beta -yl acetate (3), and (+)-(20S)-2alpha-hydroxy-20-(dimethylamino)-3beta-phthalimido-5 alpha- pregnan-4beta-yl acetate (4), as well as five known compounds, (-)-pachyaximine A (5), (+)-spiropachysine (6), (+)-Axillaridine A (7), (+)-epipachysamine D (8), and (+)-pachysamine B (9), were isolated from Pachysandra procumbens, using a bioassay-guided fractionation based on inhibition of 3H-tamoxifen binding at the antiestrogen binding site (AEBS).
Compounds 1-7 and 9 demonstrated significant activity as AEBS-inhibitory agents, and compounds 3, 5 and 9 were found to potentiate significantly the antiestrogenic effect mediated by tamoxifen in cultured Ishikawa cells. The structure elucidation of compounds 1-4 was carried out by spectral data interpretation.
Axillaridine A Description
||The herbs of Pachysandra axillaris
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Helv. Chim. Acta, 2002, 85(2):678-88. |
|Pregnane-Type Steroidal Alkaloids of Sarcococca saligna: A New Class of Cholinesterase Inhibitors[Reference: WebLink]|
METHODS AND RESULTS:
The structures of the new alkaloids salignenamide C (1), salignenamide D (2), 2b-hydroxyepipachysamine D (3), salignenamide E (4), and salignenamide F (5) were elucidated with the help of modern spectroscopic techniques, while the known alkaloids axillarine C (6), axillarine F (7), sarcorine (8), N 3 -demethylsaracodine (9), saligcinnamide (10), salignenamide A (11), vaganine A (12), Axillaridine A (13), sarsalignone (14), and sarsalignenone (15) were identified by comparing their spectral data with those reported earlier. Inhibition of electric-eel acetylcholinesterase (EC 184.108.40.206) and horse-serum butyrylcholinesterase (EC 220.127.116.11) by alkaloids 1 ± 15 were investigated.
These new cholinesterase inhibitors may act as potential leads in the discovery of clinically useful inhibitors for nervous-system disorders, particularly by reducing memory deficiency in Alzheimer×s disease patients by potentiating and effecting the cholinergic transmission process.
|J Enzyme Inhib Med Chem. 2009 Oct;24(5):1101-5. |
|Molecular dynamics simulation of Axillaridine-A: a potent natural cholinesterase inhibitor.[Pubmed: 19555175]|
Molecular Dynamics (MD) simulations were carried out for human acetylcholinesterase (hAChE) and its complex with Axillaridine A, in order to dynamically explore the active site of the protein and the behaviour of the ligand at the peripheral binding site. |
METHODS AND RESULTS:
Simulation of the enzyme alone showed that the active site of AChE is located at the bottom of a deep and narrow cavity whose surface is lined with rings of aromatic residues while Tyr72 is almost perpendicular to the Trp286, which is responsible for stable pi -pi interactions. The complexation of AChE with Axillaridine A, results in the reduction of gorge size due to interaction between the ligand and the active site residues. The gorge size was determined by the distance between the center of mass of Glu81 and Trp286. As far as the geometry of the active site is concerned, the presence of ligand in the active site alters its specific conformation, as revealed by stable hydrogen bondings established between amino acids. With the increasing interaction between ligand and the active amino acids, size of the active site of the complex decreases with respect to time.
Axillaridine A, forms stable pi -pi interactions with the aromatic ring of Tyr124 that results in inhibition of catalytic activity of the enzyme.
This pi -pi interaction keeps the substrate stable at the edge of the catalytic gorge by inhibiting its catalytic activity. The MD results clearly provide an explanation for the binding pattern of bulky steroidal alkaloids at the active site of AChE.