Science | Nature | Cell | View More
Natural Products
Cheilanthifoline
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cheilanthifoline
Price: $318 / 10mg
CAS No.: 483-44-3
Catalog No.: CFN90945
Molecular Formula: C19H19NO4
Molecular Weight: 325.36 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Powder
Source: The rhizomes of Sinomenium acutum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $175.7 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Amity University (India)
  • National Chung Hsing University (Taiwan)
  • Melbourne University (Australia)
  • Max-Planck-Insitut (Germany)
  • Universitas Airlangga (Indonesia)
  • VIT University (India)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Utrecht University (Netherlands)
  • Institute of Bioorganic Chemist... (Poland)
  • University of Fribourg (Switzerland)
  • University of Leipzig (Germany)
  • More...
Package
Featured Products
Kaempferol-3-O-(2',6'-di-O-trans-p...

Catalog No: CFN92386
CAS No: 121651-61-4
Price: $ / mg
Dehydromiltirone

Catalog No: CFN98532
CAS No: 116064-77-8
Price: $438/5mg
Luteolin-4'-O-glucoside

Catalog No: CFN93776
CAS No: 6920-38-3
Price: $ / mg
Luteolin

Catalog No: CFN98784
CAS No: 491-70-3
Price: $40/20mg
Salvianolic acid A

Catalog No: CFN99161
CAS No: 96574-01-5
Price: $128/20mg
Tricin

Catalog No: CFN98841
CAS No: 520-32-1
Price: $258/10mg
Sinigrin

Catalog No: CFN90453
CAS No: 3952-98-5
Price: $80/20mg
Soyasapogenol C

Catalog No: CFN91068
CAS No: 595-14-2
Price: $463/5mg
8-Shogaol

Catalog No: CFN92299
CAS No: 36700-45-5
Price: $368/20mg
Pinoresinol 4-O-beta-D-glucopyrano...

Catalog No: CFN97180
CAS No: 69251-96-3
Price: $100/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts. Cheilanthifoline also shows promising in vitro antiplasmodial activities against Plasmodium falciparum.
Targets: NF-kB | Antifection
In vitro:
Arch Pharm Res. 2016 May;39(5):713-20.
Anti-osteoclastogenic effects of isoquinoline alkaloids from the rhizome extract of Sinomenium acutum.[Pubmed: 26992921 ]

METHODS AND RESULTS:
A phytochemical investigation for the rhizome extract from Sinomenium acutum (Menispermaceae) resulted in the isolation of several active principles responsible for the anti-osteoclastogenic property of the extract, together with related isoquinoline alkaloids (1-13) including two new compounds, 1 and 2. Among isolated compounds, salutaridine (7), dauricumine (10), Cheilanthifoline (12), and dauriporphine (13) were observed to give significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts, respectively.
CONCLUSIONS:
The chemical structures of two newly isolated compounds, 1 and 2 were established as 8-demethoxycephatonine (1) and 7(R)-7,8-dihydrosinomenine (2), by spectroscopic analyses including 2D NMR experiments.
Phytother Res. 2010 Apr;24(4):481-5.
Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha.[Pubmed: 19496064 ]
The alkaloidal components of the Bhutanese medicinal plant Corydalis calliantha Long, which is used for the treatment of malaria, have been assessed.
METHODS AND RESULTS:
Four known alkaloids, protopine (1), scoulerine (2), Cheilanthifoline (3) and stylopine (4) are reported from this plant for the first time. The protopine alkaloid, protopine, and the tetrahydroprotoberine alkaloid, Cheilanthifoline, showed promising in vitro antiplasmodial activities against Plasmodium falciparum, both wild type (TM4) and multidrug resistant (K1) strains with IC(50) values in the range of 2.78-4.29 microM. Such activity had not been demonstrated previously for Cheilanthifoline.
CONCLUSIONS:
The results thus support, at a molecular level, the clinical use of this plant in the Bhutanese traditional medicine and identified Cheilanthifoline as a potential new antimalarial drug lead.
Cheilanthifoline Description
Source: The rhizomes of Sinomenium acutum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
N-Methyltetrahydrocolumbamine

Catalog No: CFN95590
CAS No: 92758-34-4
Price: $318/10mg
3beta-(alpha-L-Arabinopyranosyloxy...

Catalog No: CFN95459
CAS No: 435269-07-1
Price: $318/20mg
Poricoic acid B

Catalog No: CFN95050
CAS No: 137551-39-4
Price: $318/20mg
2,3-Dehydrosilychristin

Catalog No: CFN95370
CAS No: 57499-41-9
Price: $318/5mg
Peiioside B

Catalog No: CFN95336
CAS No: 1610618-91-1
Price: $318/5mg
Melitidin

Catalog No: CFN95419
CAS No: 1162664-58-5
Price: $318/10mg
Planispine A

Catalog No: CFN95348
CAS No: 1202761-42-9
Price: $318/10mg
Columbianetin beta-D-glucopyranosi...

Catalog No: CFN95038
CAS No: 55836-35-6
Price: $288/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0735 mL 15.3676 mL 30.7352 mL 61.4704 mL 76.838 mL
5 mM 0.6147 mL 3.0735 mL 6.147 mL 12.2941 mL 15.3676 mL
10 mM 0.3074 mL 1.5368 mL 3.0735 mL 6.147 mL 7.6838 mL
50 mM 0.0615 mL 0.3074 mL 0.6147 mL 1.2294 mL 1.5368 mL
100 mM 0.0307 mL 0.1537 mL 0.3074 mL 0.6147 mL 0.7684 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Kaempferol-3-O-(2',6'-di-O-trans-p...

Catalog No: CFN92386
CAS No: 121651-61-4
Price: $ / mg
Dehydromiltirone

Catalog No: CFN98532
CAS No: 116064-77-8
Price: $438/5mg
Luteolin-4'-O-glucoside

Catalog No: CFN93776
CAS No: 6920-38-3
Price: $ / mg
Luteolin

Catalog No: CFN98784
CAS No: 491-70-3
Price: $40/20mg
Salvianolic acid A

Catalog No: CFN99161
CAS No: 96574-01-5
Price: $128/20mg
Tricin

Catalog No: CFN98841
CAS No: 520-32-1
Price: $258/10mg
Sinigrin

Catalog No: CFN90453
CAS No: 3952-98-5
Price: $80/20mg
Soyasapogenol C

Catalog No: CFN91068
CAS No: 595-14-2
Price: $463/5mg
8-Shogaol

Catalog No: CFN92299
CAS No: 36700-45-5
Price: $368/20mg
Pinoresinol 4-O-beta-D-glucopyrano...

Catalog No: CFN97180
CAS No: 69251-96-3
Price: $100/20mg
Tags: buy Cheilanthifoline | Cheilanthifoline supplier | purchase Cheilanthifoline | Cheilanthifoline cost | Cheilanthifoline manufacturer | order Cheilanthifoline | Cheilanthifoline distributor