ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
Solafuranone
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $222.6 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
J of the Korean Society of Food S...2016...Front Cell Dev Biol.2021, 9:588093.The Journal of Internal Korean Me...2015...Int J Food Sci Nutr.2019, 70(7):825-833J Ethnopharmacol.2020, 269:113752. Int J Mol Sci.2021, 22(21):11447.J Agric Food Chem.2018, 66(1):351-358Kor. J. Herbol.2019, 34(2):59-66
Plants (Basel).2021, 10(7):1376.Molecules.2019, 24(19):E3417J Pharm Biomed Anal.2019, 164:119-127Int. J. Mol. Sci. 2022, 23(3),1696.Biotechnol Bioeng....2020...Applied Biological Chemistry ...2021...Antioxidants (Basel).2021, 10(9):1487.Acta Chromatographica2016, 29(3)
J of Food Quality2020, 8851285.Plant Sci.2020, 301:110656.Chemistry of Plant Materials....2016...Front Pharmacol.2021, 12:762829. Plants (Basel).2021, 10(4):702.Front Cell Dev Biol.2021, 9:638174. Int J Mol Sci.2018, 19(9):E2825
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Our products had been exported to the following research institutions and universities, And still growing.
Wroclaw Medical University (Poland)Universidad Veracuzana (Mexico)Warszawski Uniwersytet Medyczny (Poland)University of Maryland (USA)
Universidade da Beira Interior (Germany)Chulalongkorn University (Thailand)University of Maryland School o... (USA)Stanford University (USA)
Universidade Federal de Goias (... (Brazil)University of Toulouse (France)Mendel University in Brno (Czech Republic)
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Solafuranone
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Food Funct.2020, 11(2):1322-1333.Foods.2021, 10(11):2627. Environ Toxicol.2019, 34(12):1354-1362Microchemical Journal2018, 137:168-173J AOAC Int.2021, 104(6):1634-1651.Molecules.2016, 21(6)J Ethnopharmacol.2017, 198:205-213Biochem Systematics and Ecology2017, 11-18Antioxidants (Basel).2021, 10(9):1487.J Nat Prod.2015, 78(6):1339-4
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Cytotoxic Compound Library |
| Description: |
Solafuranone possess cytotoxic activity against human cancer cell lines at concentrations up to 30 μM.
Anti-inflammatory. |
| In vitro: |
| Int J Mol Sci . 2013 Jun 14;14(6):12581-92. | | Anti-inflammatory components from the root of Solanum erianthum[Pubmed: 23771024] | | Two new norsesquiterpenoids, solanerianones A and B (1-2), together with nine known compounds, including four sesquiterpenoids, (-)-solavetivone (3), (+)-anhydro-β-rotunol (4), Solafuranone (5), lycifuranone A (6); one alkaloid, N-trans-feruloyltyramine (7); one fatty acid, palmitic acid (8); one phenylalkanoid, acetovanillone (9), and two steroids, β-sitosterol (10) and stigmasterol (11) were isolated from the n-hexane-soluble part of the roots of Solanum erianthum. Their structures were elucidated on the basis of physical and spectroscopic data analyses. The anti-inflammatory activity of these isolates was monitored by nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells. The cytotoxicity towards human lung squamous carcinoma (CH27), human hepatocellular carcinoma (Hep 3B), human oral squamous carcinoma (HSC-3) and human melanoma (M21) cell lines was also screened by using an MTT assay. Of the compounds tested, 3 exhibited the strongest NO inhibition with the average maximum inhibition (Emax) at 100 μM and median inhibitory concentration (IC50) values of 98.23% ± 0.08% and 65.54 ± 0.18 μM, respectively. None of compounds (1-9) was found to possess cytotoxic activity against human cancer cell lines at concentrations up to 30 μM. |
|
Solafuranone Description
| Source: |
The herbs of Solanum indicum |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
4.3048 mL |
21.5239 mL |
43.0478 mL |
86.0956 mL |
107.6195 mL |
| 5 mM |
0.861 mL |
4.3048 mL |
8.6096 mL |
17.2191 mL |
21.5239 mL |
| 10 mM |
0.4305 mL |
2.1524 mL |
4.3048 mL |
8.6096 mL |
10.7619 mL |
| 50 mM |
0.0861 mL |
0.4305 mL |
0.861 mL |
1.7219 mL |
2.1524 mL |
| 100 mM |
0.043 mL |
0.2152 mL |
0.4305 mL |
0.861 mL |
1.0762 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| J Nat Prod . 2001 Sep;64(9):1232-3. | | Cytotoxic and novel compounds from Solanum indicum[Pubmed: 11575964] | | Solavetivone (1), cytotoxic to OVCAR-3 cells with an IC(50) value of 0.1 mM, has been isolated from Solanum indicum. In addition, a novel Solafuranone (2) and three known compounds, scopoletin, N-(p-trans-coumaroyl)tyramine, and N-trans-feruloyltyramine, were isolated for the first time from this plant. The structures of the above compounds were established by means of spectroscopic and X-ray analyses. | | ChemInform 38(32) | | Efficient Approach to 4Benzyl5,5-dimethyldihydrofuranones: Total Synthesis of (.+-.)-Solafuranone[Reference: WebLink] | | A six-step general and very efficient synthesis of 4-(arylmethyl)-5,5-dialkyldihydrofuranones starting from corresponding aryl aldehyde has been developed. Solafuranone, a novel furanone isolated from the Chinese folk medicine Solanum indicum, has been accomplished starting from 2,6-dimethylbenzaldehyde in six steps in an overall yield of 70%. Contrary to expectations, Solafuranone and its analogue failed to exhibit any significant cytotoxicity against A549 (lung adenocarcinoma) and HL60 (leukemia cells) cell lines. |
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