Science | Nature | Cell | View More
Natural Products
Beta-mangostin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Beta-mangostin
Price: $218 / 10mg
CAS No.: 20931-37-7
Catalog No.: CFN99723
Molecular Formula: C25H28O6
Molecular Weight: 424.49 g/mol
Purity: >=98%
Type of Compound: Xanthones
Physical Desc.: Yellow powder
Source: The fruits of Garcinia mangostana
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $102.7 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Research Unit Molecular Epigene... (Germany)
  • Universitas islam negeri Jakarta (Indonesia)
  • Tokyo Woman's Christian University (Japan)
  • Anna University (India)
  • National Research Council of Ca... (Canada)
  • Instytut Nawozów Sztucznych w ... (Poland)
  • University of East Anglia (United Kingdom)
  • Sant Gadge Baba Amravati Univer... (India)
  • Siksha O Anusandhan University (India)
  • Universidad Veracuzana (Mexico)
  • More...
Package
Featured Products
Luteolin-7-O-glucuronide

Catalog No: CFN98512
CAS No: 29741-10-4
Price: $118/20mg
Solasodine

Catalog No: CFN90200
CAS No: 126-17-0
Price: $168/20mg
Intermedine N-oxide

Catalog No: CFN00459
CAS No: 95462-14-9
Price: $ / mg
Arctigenin

Catalog No: CFN99534
CAS No: 7770-78-7
Price: $40/20mg
Ginsenoside Re

Catalog No: CFN99974
CAS No: 52286-59-6
Price: $40/20mg
Alisol C

Catalog No: CFN92545
CAS No: 30489-27-1
Price: $318/5mg
Beta-Carotene

Catalog No: CFN98117
CAS No: 7235-40-7
Price: $40/20mg
Cordycepin

Catalog No: CFN98566
CAS No: 73-03-0
Price: $40/20mg
(-)-Catechin gallate(CG)

Catalog No: CFN98504
CAS No: 130405-40-2
Price: $318/20mg
Oroxylin A

Catalog No: CFN98540
CAS No: 480-11-5
Price: $80/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity against B. cereus, and Mycobacterium tuberculosis with the MIC value of 0.25, and 6.25 microg/ml, respectively. It also shows antimalarial activity against Plasmodium falciparum with IC(50) values of 7.2 microg/ml.
Targets: COX | TNF-α | PGE | NF-kB | IL Receptor | Antifection
In vitro:
J Ethnopharmacol. 2014 Apr 28;153(2):435-45.
β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo.[Pubmed: 24607509]
The fruit hull of Garcinia mangostana Linn. has been used in traditional medicine for treatment of various inflammatory diseases. Hence, this study aims to investigate the in vitro and in vivo anti-inflammatory effect of β mangostin (βM), a major compound present in Garcinia mangostana.
METHODS AND RESULTS:
The in silico analysis of inflammatory mediators such as cyclooxygenase (COX) and nuclear factor-kappa B (NF-kB) were performed via molecular docking. Further evaluation of anti-inflammatory effect was conducted in lipopolysaccharide (LPS) induced RAW 264.7 macrophages. Suppression of activated NF-kB was analyzed by high content screening. βM triggered inhibition of COX-1 and COX-2 in vitro were studied using biochemical kit. The in vivo model used in this study was carrageenan-induced peritonitis model, where reduction in carrageenan-induced peritonitis is measured by leukocyte migration and vascular permeability. In addition, the evaluation of βM׳s effect on carrageenan induced TNF-α and IL-1β release on peritoneal fluid was also carried out. Treatment with βM could inhibit the LPS-induced NO production but not the viability of RAW 264.7. Similarly, βM inhibited PGE2 production and the cytokines: TNF-α and IL-6. The COX catalyzed prostaglandin biosynthesis assay had showed selective COX-2 inhibition with a 53.0±6.01% inhibition at 20 μg/ml. Apart from this, βM was capable in repressing translocation of NF-kB into the nucleus. These results were concurrent with molecular docking which revealed COX-2 selectivity and NF-kB inhibition. The in vivo analysis showed that after four hours of peritonitis, βM was unable to reduce vascular permeability, yet could decrease the total leukocyte migration; particularly, neutrophils. Meanwhile, dexamethasone 0.5 mg/kg, successfully reduced vascular permeability. The levels of TNF-α and IL-1β in peritoneal fluid was reduced significantly by βM treatment.
CONCLUSIONS:
The current study supports the traditional use of Garcinia mangostana fruit hull for treatment of inflammatory conditions. In addition, it is clear that the anti-inflammatory efficacy of this plant is not limited to the presence of α and γ, but β also with significant activity.
Fitoterapia. 2014 Oct;98:179-83.
Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa.[Pubmed: 25110196]

METHODS AND RESULTS:
A phytochemical investigation of the acetone extract from the immature fruits of Garcinia cowa led to the isolation of two novel tetraoxygenated xanthones, garcicowanones A (1) and B (2), together with eight known tetraoxygeanted xanthones. Their structures were determined by spectroscopic analysis.All isolated compounds were evaluated for their antibacterial activity against Bacillus cereus TISTR 688, Bacillus subtilis TISTR 008, Micrococcus luteus TISTR 884, Staphylococcus aureus TISTR 1466, Escherichia coli TISTR 780, Pseudomonas aeruginosa TISTR 781, Salmonella typhimurium TISTR 292 and Staphylococcus epidermidis ATCC 12228.
CONCLUSIONS:
α-Mangostin showed potent activity (MIC 0.25-1 μg/mL) against three Gram-positive strains and garcicowanone A and Beta-mangostin exhibited strong antibacterial activity against B. cereus with the same MIC values of 0.25 μg/mL.
Tumour Biol . 2017 Nov;39(11):1010428317731451.
Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G 0/G 1 cell-cycle arrest[Pubmed: 29110583]
Abstract Xanthones are phytochemical compounds found in a number of fruits and vegetables. Characteristically, they are noted to be made of diverse properties based on their biological, biochemical, and pharmacological actions. Accordingly, the apoptosis mechanisms induced by Beta-mangostin, a xanthone compound isolated from Cratoxylum arborescens in the human promyelocytic leukemia cell line (HL60) in vitro, were examined in this study. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was done to estimate the cytotoxicity effect of β-mangostin on the HL60 cell line. Acridine orange/propidium iodide and Hoechst 33342 dyes and Annexin V tests were conducted to detect the apoptosis features. Caspase-3 and caspase-9 activities; reactive oxygen species; real-time polymerase chain reaction for Bcl-2, Bax, caspase-3, and caspase-9 Hsp70 genes; and western blot for p53, cytochrome c, and pro- and cleavage-caspase-3 and caspase-9 were assessed to examine the apoptosis mechanism. Cell-cycle analysis conducted revealed that β-mangostin inhibited the growth of HL60 at 58 μM in 24 h. The administration of β-mangostin with HL60 caused cell morphological changes related to apoptosis which increased the number of early and late apoptotic cells. The β-mangostin-catalyzed apoptosis action through caspase-3, caspase-7, and caspase-9 activation overproduced reactive oxygen species which downregulated the expression of antiapoptotic genes Bcl-2 and HSP70. Conversely, the expression of the apoptotic genes Bax, caspase-3, and caspase-9 were upregulated. Meanwhile, at the protein level, β-mangostin activated the formation of cleaved caspase-3 and caspase-9 and also upregulated the p53. β-mangostin arrested the cell cycle at the G0/G1 phase. Overall, the results for β-mangostin showed an antiproliferative effect in HL60 via stopping the cell cycle at the G0/G1 phase and prompted the intrinsic apoptosis pathway. Keywords: Apoptosis; HL60 cell line; Beta-mangostin; intrinsic pathway; leukemia; xanthones.
Environ Toxicol . 2017 Nov;32(11):2360-2370.
β-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways[Pubmed: 28722351]
Abstract β-mangostin is a dietary xanthone that has been reported to have the anticancer properties in some human cancer cell types. However, the antimetastatic effect and molecular mechanism of β-mangostin action in human hepatocellular carcinoma (HCC) cells remain unknown. In this study, we found that β-mangostin did not induce cytotoxicity in human HCC cells (SK-Hep-1, Huh-7 and HA22T/VGH cells). β-mangostin could inhibit migration and invasion of human HCC cells. Meanwhile, β-mangostin significantly decreased the protein activities and expression of matrix metalloproteinase (MMP)-2 and MMP-9 via increasing the activation of MEK1/2, ERK1/2, MEK4 and JNK1/2 signaling pathways. Furthermore, using specific inhibitor for ERK1/2 (PD98059) and JNK1/2 (JNKII) significantly restored the expression of MMP-2/-9 and invasion by β-mangostin treatment in Huh-7 cells. In addition, β-mangostin effectively restored the protein levels and transcription activity of MMP-2 and MMP-9 in siERK or siJNK-transfected Huh-7 cells, concomitantly with promotion on cell migration and invasion. Taken together, these findings are the first to demonstrate the antimetastatic activity of β-mangostin against human HCC cells, which may act as a promising therapeutic agent for the treatment of HCC. Keywords: MMP-2; MMP-9; hepatocellular carcinoma cell; invasion; migration; β-Mangostin.
Beta-mangostin Description
Source: The fruits of Garcinia mangostana
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Umbelliferone 7-O-rutinoside

Catalog No: CFN95431
CAS No: 135064-04-9
Price: $318/10mg
Oxytroflavoside D

Catalog No: CFN95491
CAS No: 1391144-83-4
Price: $318/10mg
Silybin A

Catalog No: CFN95149
CAS No: 22888-70-6
Price: $318/20mg
Planispine A

Catalog No: CFN95348
CAS No: 1202761-42-9
Price: $318/10mg
Melitidin

Catalog No: CFN95419
CAS No: 1162664-58-5
Price: $318/10mg
3''-O-Caffeoylhesperidin

Catalog No: CFN95564
CAS No: N/A
Price: $318/5mg
9-Octadecenedioic acid

Catalog No: CFN95301
CAS No: 4494-16-0
Price: $218/5mg
8-Hydroxy-5,7-dimethoxyflavanone

Catalog No: CFN95580
CAS No: 201230-40-2
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3558 mL 11.7788 mL 23.5577 mL 47.1154 mL 58.8942 mL
5 mM 0.4712 mL 2.3558 mL 4.7115 mL 9.4231 mL 11.7788 mL
10 mM 0.2356 mL 1.1779 mL 2.3558 mL 4.7115 mL 5.8894 mL
50 mM 0.0471 mL 0.2356 mL 0.4712 mL 0.9423 mL 1.1779 mL
100 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.4712 mL 0.5889 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Cell Research:
Planta Med. 2014 Jun;80(8-9):676-81.
In vitro antiplasmodial activity of benzophenones and xanthones from edible fruits of Garcinia species.[Pubmed: 24963617]
Species of Garcinia have been used to combat malaria in traditional African and Asian medicines, including Ayurveda.
METHODS AND RESULTS:
In the current study, we have identified antiplasmodial benzophenone and xanthone compounds from edible Garcinia species by testing for in vitro inhibitory activity against Plasmodium falciparum. Whole fruits of Garcinia xanthochymus, G. mangostana, G. spicata, and G. livingstonei were extracted and tested for antiplasmodial activity. Garcinia xanthochymus was subjected to bioactivity-guided fractionation to identify active partitions. Purified benzophenones (1-9) and xanthones (10-18) were then screened in the plasmodial lactate dehydrogenase assay and tested for cytotoxicity against mammalian (Vero) cells. The benzophenones guttiferone E (4), isoxanthochymol (5), and guttiferone H (6), isolated from G. xanthochymus, and the xanthones α-mangostin (15), β-mangostin (16), and 3-isomangostin (17), known from G. mangostana, showed antiplasmodial activity with IC50 values in the range of 4.71-11.40 μM. Artemisinin and chloroquine were used as positive controls and exhibited IC50 values in the range of 0.01-0.24 μM.
CONCLUSIONS:
The identification of antiplasmodial benzophenone and xanthone compounds from G. xanthochymus and G. mangostana provides evidence for the antiplasmodial activity of Garcinia species and warrants further investigation of these fruits as dietary sources of chemopreventive compounds.
Structure Identification:
Chem Pharm Bull (Tokyo). 2006 May;54(5):745-7.
Cytotoxic and antimalarial prenylated xanthones from Cratoxylum cochinchinense.[Pubmed: 16651783]

METHODS AND RESULTS:
A new prenylated xanthone, 5-O-methylcelebixanthone (1), together with six known compounds; celebixanthone (2), 1,3,7-trihydroxy-2,4-di(3-methylbut-2-enyl)xanthone (3), cochinchinone A (4), alpha-mangostin (5), Beta-mangostin (6) and cochinchinone C (7) were isolated from roots of Cratoxylum cochinchinense. Their structures were elucidated by spectroscopic methods.
CONCLUSIONS:
Compounds 2 and 4-7 showed cytotoxic activity against the human lung cancer cell line (NCI-H187) with IC(50) values ranging from 0.65 to 5.2 microg/ml. Compounds 1, 2, 6 and 7 also showed antimalarial activity against Plasmodium falciparum with IC(50) values of 3.2, 4.9, 7.2 and 2.6 microg/ml, respectively.
Chem Pharm Bull (Tokyo). 2003 Jul;51(7):857-9.
Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.[Pubmed: 12843596]

METHODS AND RESULTS:
Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. Alpha- and Beta-mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 microg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities.
CONCLUSIONS:
Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.
Luteolin-7-O-glucuronide

Catalog No: CFN98512
CAS No: 29741-10-4
Price: $118/20mg
Solasodine

Catalog No: CFN90200
CAS No: 126-17-0
Price: $168/20mg
Intermedine N-oxide

Catalog No: CFN00459
CAS No: 95462-14-9
Price: $ / mg
Arctigenin

Catalog No: CFN99534
CAS No: 7770-78-7
Price: $40/20mg
Ginsenoside Re

Catalog No: CFN99974
CAS No: 52286-59-6
Price: $40/20mg
Alisol C

Catalog No: CFN92545
CAS No: 30489-27-1
Price: $318/5mg
Beta-Carotene

Catalog No: CFN98117
CAS No: 7235-40-7
Price: $40/20mg
Cordycepin

Catalog No: CFN98566
CAS No: 73-03-0
Price: $40/20mg
(-)-Catechin gallate(CG)

Catalog No: CFN98504
CAS No: 130405-40-2
Price: $318/20mg
Oroxylin A

Catalog No: CFN98540
CAS No: 480-11-5
Price: $80/20mg
Tags: buy Beta-mangostin | Beta-mangostin supplier | purchase Beta-mangostin | Beta-mangostin cost | Beta-mangostin manufacturer | order Beta-mangostin | Beta-mangostin distributor