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2. Pharmacological research
3. Inhibitors
Betulinic acid methyl ester
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $141.7 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Indian J Pharm Sci....2022...Food Sci Biotechnol....2016...Mol Immunol. 2016, 78:121-132J Mass Spectrom.2022, 57(2):e4810.ACS Omega.2022, 7(44):40009-40020.Korean J. Medicinal Crop Sci....2021...Food and Bioprocess Technology...2017...J Pharm Biomed Anal.2019, 164:119-127
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Betulinic acid methyl ester
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Tissue Cell.2022, 78:101901.Molecules2022, 27(9):2827.Metabolites.2020, 10(12):497.Int Immunopharmacol.2019, 71:361-371Molecules2022, 27(3),1140.SRM Institute of Sci&Tech2022, 34(1): 32-37Am J Chin Med.2022, 1-20.Chemistry of Plant Raw Materials2022, 20220210569.Korea Institute of Oriental Medicine2020, doi: 10.21203.J of Advanced Scientific R.2020, 11(3), p109-120.
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
Betulinic acid methyl ester showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro.It also inhibited B16 2F2 cell proliferation by induction of apoptosis. |
| Targets: |
Antifection |
| In vitro: |
| Parasitol Res. 2009 Jul;105(1):275-9. | | Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice.[Pubmed: 19367418] | Malaria is one of the most important tropical diseases and mainly affects populations living in developing countries. Reduced sensitivity of Plasmodium sp. to formerly recommended antimalarial drugs places an increasing burden on malaria control programs as well as on national health systems in endemic countries. The present study aims to evaluate the antimalarial activity of betulinic acid and its derivative compounds, betulonic acid, betulinic acid acetate, Betulinic acid methyl ester, and Betulinic acid methyl ester acetate.
METHODS AND RESULTS:
These substances showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro, with IC(50) values of 9.89, 10.01, 5.99, 51.58, and 45.79 microM, respectively. Mice infected with Plasmodium berghei and treated with betulinic acid acetate had a dose-dependent reduction of parasitemia.
CONCLUSIONS:
Our results indicate that betulinic acid and its derivative compounds are candidates for the development of new antimalarial drugs. | | J Nat Prod. 2002 May;65(5):645-8. | | Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line.[Pubmed: 12027734 ] | In a study to investigate the relationship between the chemical structure and the differentiation-inducing activity of pentacyclic triterpenes, several lupane, oleanane, and ursane triterpenes were prepared and their effects on B16 2F2 melanoma cell differentiation and growth were examined.
METHODS AND RESULTS:
Eleven lupane triterpenes used in this study acted on the melanoma cells as a melanogen, but no induction of melanogenesis of B16 2F2 cells by oleanane and ursane was detected. The differences at C-17 of the lupane series and acetylation of the OH group at C-3 did not markedly influence their activities. However, the ED(50) value for up-regulation of melanin biosynthesis was markedly decreased by the oxidation of the OH group at C-3 of lupeol (1). Betulinic acid (11), its methyl ester (Betulinic acid methyl ester, 12), lup-28-al-20(29)-ene-3beta-ol (9), and lup-28-al-20(29)-en-3-one (10) inhibited B16 2F2 cell proliferation by induction of apoptosis.
CONCLUSIONS:
These findings suggested that the carbonyl group at C-17 might be essential for the apoptotic effects of these compounds on B16 2F2 cells. |
|
Betulinic acid methyl ester Description
| Source: |
The herbs of Ziziphus jujuba |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.1245 mL |
10.6225 mL |
21.245 mL |
42.4899 mL |
53.1124 mL |
| 5 mM |
0.4249 mL |
2.1245 mL |
4.249 mL |
8.498 mL |
10.6225 mL |
| 10 mM |
0.2124 mL |
1.0622 mL |
2.1245 mL |
4.249 mL |
5.3112 mL |
| 50 mM |
0.0425 mL |
0.2124 mL |
0.4249 mL |
0.8498 mL |
1.0622 mL |
| 100 mM |
0.0212 mL |
0.1062 mL |
0.2124 mL |
0.4249 mL |
0.5311 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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