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Betulinic acid methyl ester
Betulinic acid methyl ester
Information
CAS No. 2259-06-5 Price $218 / 10mg
Catalog No.CFN91073Purity>=98%
Molecular Weight470.7Type of CompoundTriterpenoids
FormulaC31H50O3Physical DescriptionPowder
Download COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    Betulinic acid methyl ester

    Betulinic acid methyl ester
    Product Name Betulinic acid methyl ester
    CAS No.: 2259-06-5
    Catalog No.: CFN91073
    Molecular Formula: C31H50O3
    Molecular Weight: 470.7 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Targets: Antifection
    Source: The herbs of Ziziphus jujuba
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $218 / 10mg
    Download: COA    MSDS
    Similar structural: Comparison (Web)  (SDF)
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    product package
  • Tissue Cell.2022, 78:101901.
  • Molecules2022, 27(9):2827.
  • Metabolites.2020, 10(12):497.
  • Int Immunopharmacol.2019, 71:361-371
  • Molecules2022, 27(3),1140.
  • SRM Institute of Sci&Tech2022, 34(1): 32-37
  • Am J Chin Med.2022, 1-20.
  • Chemistry of Plant Raw Materials2022, 20220210569.
  • Korea Institute of Oriental Medicine2020, doi: 10.21203.
  • J of Advanced Scientific R.2020, 11(3), p109-120.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
    Biological Activity
    Description: Betulinic acid methyl ester showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro.It also inhibited B16 2F2 cell proliferation by induction of apoptosis.
    Targets: Antifection
    In vitro:
    Parasitol Res. 2009 Jul;105(1):275-9.
    Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice.[Pubmed: 19367418]
    Malaria is one of the most important tropical diseases and mainly affects populations living in developing countries. Reduced sensitivity of Plasmodium sp. to formerly recommended antimalarial drugs places an increasing burden on malaria control programs as well as on national health systems in endemic countries. The present study aims to evaluate the antimalarial activity of betulinic acid and its derivative compounds, betulonic acid, betulinic acid acetate, Betulinic acid methyl ester, and Betulinic acid methyl ester acetate.
    METHODS AND RESULTS:
    These substances showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro, with IC(50) values of 9.89, 10.01, 5.99, 51.58, and 45.79 microM, respectively. Mice infected with Plasmodium berghei and treated with betulinic acid acetate had a dose-dependent reduction of parasitemia.
    CONCLUSIONS:
    Our results indicate that betulinic acid and its derivative compounds are candidates for the development of new antimalarial drugs.
    J Nat Prod. 2002 May;65(5):645-8.
    Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line.[Pubmed: 12027734 ]
    In a study to investigate the relationship between the chemical structure and the differentiation-inducing activity of pentacyclic triterpenes, several lupane, oleanane, and ursane triterpenes were prepared and their effects on B16 2F2 melanoma cell differentiation and growth were examined.
    METHODS AND RESULTS:
    Eleven lupane triterpenes used in this study acted on the melanoma cells as a melanogen, but no induction of melanogenesis of B16 2F2 cells by oleanane and ursane was detected. The differences at C-17 of the lupane series and acetylation of the OH group at C-3 did not markedly influence their activities. However, the ED(50) value for up-regulation of melanin biosynthesis was markedly decreased by the oxidation of the OH group at C-3 of lupeol (1). Betulinic acid (11), its methyl ester (Betulinic acid methyl ester, 12), lup-28-al-20(29)-ene-3beta-ol (9), and lup-28-al-20(29)-en-3-one (10) inhibited B16 2F2 cell proliferation by induction of apoptosis.
    CONCLUSIONS:
    These findings suggested that the carbonyl group at C-17 might be essential for the apoptotic effects of these compounds on B16 2F2 cells.
    Betulinic acid methyl ester Description
    Source: The herbs of Ziziphus jujuba
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1245 mL 10.6225 mL 21.245 mL 42.4899 mL 53.1124 mL
    5 mM 0.4249 mL 2.1245 mL 4.249 mL 8.498 mL 10.6225 mL
    10 mM 0.2124 mL 1.0622 mL 2.1245 mL 4.249 mL 5.3112 mL
    50 mM 0.0425 mL 0.2124 mL 0.4249 mL 0.8498 mL 1.0622 mL
    100 mM 0.0212 mL 0.1062 mL 0.2124 mL 0.4249 mL 0.5311 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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