ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $331.2 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Antioxidants (Basel).2020, 9(4):326. Asian Pac J Cancer Prev....2019...Oncol Rep.2016, 35(3):1356-64Biomolecules.2021, 11(10):1537.Nat Commun.2019, 10(1):2745Molecules.2020, 25(18),4089.J Ethnopharmacol.2020, 254:112733. Pharmaceuticals.2022, 15(4), 402.
Bioorg Med Chem.2020, 28(12):115553.Aquaculture2017, 481:94-102Metabolites.2020, 10(12):497.Front Microbiol.2020, 11:583594.Scientific World Journal....2014...Phytochemistry.2017, 141:162-170Drug Des Devel Ther.2020, 14:969-976.Journal of Molecular Liquids...2022...
J Cell Mol Med.2018, 22(9):4236-4242Pol J Microbiol.2021, 70(1):117-130.Int J Mol Sci.2019, 20(9):E2244Antiviral Res.2013, 98(3):386-93Front Pharmacol.2022, 13:870553.J Nat Med.2017, 71(2):457-462Appl. Sci.2020, 10,1304
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Our products had been exported to the following research institutions and universities, And still growing.
Amity University (India)University of Otago (New Zealand)Semmelweis Unicersity (Hungary)Center for protein Engineering ... (Belgium)
University of Hertfordshire (United Kingdom)University of Hawaii Cancer Center (USA)University of Malaya (Malaysia)Korea Institute of Oriental Med... (Korea)
Weizmann Institute of Science (Israel)Universitas Airlangga (Indonesia)Max-Planck-Insitut (Germany)
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Physalin L
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manager@chemfaces.com
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+86-27-84254680
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Asian Journal of Chemistry2018, 30(12):2699-2703Nat Prod Sci.2018, 24(3):206Front. Plant Sci.2022, 13:757852.J Applied Biological Chemistry2021, 64(2):185-192Drug Chem Toxicol.2020, 1-14. Research Square2021, 10.21203.Plant Cell Tiss Org2017, 479-486Int J Mol Sci.2019, 20(14):E3538J Pharm Pharmacol.2022, rgac033. Antioxidants (Basel).2019, 8(8):E307
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Steroids Compound Library |
| Description: |
Physalin L shows a distinct fluorescence spot under UV 365 nm with good separation. |
| In vitro: |
| Steroids. 2012 Apr;77(5):441-7. | | Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors.[Pubmed: 22197662] | Michael reaction acceptors (MRAs) are a class of active molecules that are directly or indirectly involved in various cellular processes, including the regulation of many signaling pathways.
METHODS AND RESULTS:
In this study, the inducible nitric oxide synthase (iNOS) assay was used to demonstrate that the dichloromethane extract of Physalis alkekengi var. franchetii (DCEP) possesses anti-inflammatory activity that might be attributed to the modification of key cysteine residues in IKKβ by the MRAs in DCEP. To isolate these MRAs, glutathione (GSH) was employed, and a simple ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) screening method was developed to investigate the GSH conjugates with potential MRAs. Five physalins, including one new compound isophysalin A (2), together with four known steroidal compounds, physalin A (1), physalin O (3), Physalin L (4) and physalin G (5), were isolated to evaluate the GSH conjugating abilities, and it was indicated that compounds 1, 2 and 3, which had a common α,β-unsaturated ketone moiety, exhibited conjugating abilities with GSH and also showed significant nitric oxide (NO) production inhibiting activities. The anti-inflammatory activities of compounds 1, 2 and 3 might be attributed to their targeting multiple cysteine residues on IKKβ; therefore, the alkylation of IKKβ by compound 1 was further studied by micrOTOF-MS.
CONCLUSIONS:
The result showed that six cysteine residues (C(59), C(179), C(299), C(370), C(412), and C(618)) were alkylated, which indicated that IKKβ is a potential target for the anti-inflammatory activity of physalin A. |
|
Physalin L Description
| Source: |
The herbs of Physalis alkekengi |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.892 mL |
9.4598 mL |
18.9197 mL |
37.8394 mL |
47.2992 mL |
| 5 mM |
0.3784 mL |
1.892 mL |
3.7839 mL |
7.5679 mL |
9.4598 mL |
| 10 mM |
0.1892 mL |
0.946 mL |
1.892 mL |
3.7839 mL |
4.7299 mL |
| 50 mM |
0.0378 mL |
0.1892 mL |
0.3784 mL |
0.7568 mL |
0.946 mL |
| 100 mM |
0.0189 mL |
0.0946 mL |
0.1892 mL |
0.3784 mL |
0.473 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(16):2103-5. | | Investigation on quality standard of Franchet groundcherry.[Pubmed: 21046739] | To develop identification and assay methods of Franchet groundcherry.
METHODS AND RESULTS:
TLC method was used to identify of Physalin L in the sample using high performance silica gel G plate and a mixture of chloroform-acetone-methanol (25:1:1) as a developing solvent. In the chromatogram, Physalin L showed a distinct fluorescence spot under UV 365 nm with good separation. In the HPLC method, luteoloside was separated on a Venusil XBP C18 (4.6 mm x 250 mm, 5 microm) column with acetonitrile-0. 2% phosphoric acid (20:80) as the mobile phase with flow rate of 1 mL x min(-1). The detection wavelength was set at 350 nm.
For the HPLC quantitation method, the calibration curve of luteoloside displayed ideal linearity over the range of 0.50-249.40 mg x L(-1) with the regression equation of Y = 55,313X + 3.1641 (r = 1.000). The average recovery of luteoloside was 98.79% with a RSD of 1.1%. And the intra-day and inter-day precisions were less than 2%.
CONCLUSIONS:
The TLC identification and HPLC determination were sensitive, reliable and repeatable and can be applied for the quality evaluation and assessment of Franchet Groundcherry Calyx. |
|
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