ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $331.2 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Faculty of Chem. & Nat. Resource ...2014...Korean J. Medicinal Crop Sci...2021...Pharmacogn Mag.2015, 11:S585-91Biochem Biophys Res Commun....2020...Natural Product Communications...2020...BMC Complement Altern Med.2014, 14:242Int J Mol Sci.2019, 21(1):E265Foods.2021, 10(12):2929.
Int J Mol Sci.2017, 18(5)J Med Food.2021, 24(2):151-160.Cell Rep.2020, 32(11):108158.Eur J Neurosci.2021, 53(11):3548-3560.Oncol Rep.2021, 46(2):166.J Pharm Biomed Anal.2022, 207:114398. Inflammation2015, 38(1):445-55Int J Mol Sci.2021, 22(16):8604.
Applied Biological Chemistry...2022...Food Chem.2021, 377:131976. Current Pharmaceutical Analysis...2017...Korean J. Medicinal Crop Sci....2018...Psychopharmacology (Berl).2020, 10.1007Cell Physiol Biochem....2017...Food Sci Biotechnol....2016...
Our products had been exported to the following research institutions and universities, And still growing.
Universidad de La Salle (Mexico)Celltrion Chemical Research Ins... (Korea)The University of Newcastle (Australia)University of Brasilia (Brazil)
University of Virginia (USA)Chang Gung University (Taiwan)Monash University Malaysia (Malaysia)Centrum Menselijke Erfelijkheid (Belgium)
The Vancouver Prostate Centre (... (Canada)John Innes Centre (United Kingdom)CSIRO - Agriculture Flagship (Australia)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Anal Bioanal Chem. 2016, 408(15)Molecules.2019, 24(24),4583Biomed Pharmacother.2021, 139:111585. J Ethnopharmacol.2020, 254:112733. BMC Plant Biol.2020, 20(1):214. Chem. of Vegetable Raw Materials2020, 97-105Int J Mol Sci.2021, 22(8):4211.Chin J Appl. Physiol.2019, 35(3):283-288Univerzita Karlova2021, 20.500.11956.J of Advanced Scientific R.2020, 11(3), p109-120.
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Steroids Compound Library
|| Physalin L shows a distinct fluorescence spot under UV 365 nm with good separation.|
|Steroids. 2012 Apr;77(5):441-7. |
|Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors.[Pubmed: 22197662]|
|Michael reaction acceptors (MRAs) are a class of active molecules that are directly or indirectly involved in various cellular processes, including the regulation of many signaling pathways. |
METHODS AND RESULTS:
In this study, the inducible nitric oxide synthase (iNOS) assay was used to demonstrate that the dichloromethane extract of Physalis alkekengi var. franchetii (DCEP) possesses anti-inflammatory activity that might be attributed to the modification of key cysteine residues in IKKβ by the MRAs in DCEP. To isolate these MRAs, glutathione (GSH) was employed, and a simple ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) screening method was developed to investigate the GSH conjugates with potential MRAs. Five physalins, including one new compound isophysalin A (2), together with four known steroidal compounds, physalin A (1), physalin O (3), Physalin L (4) and physalin G (5), were isolated to evaluate the GSH conjugating abilities, and it was indicated that compounds 1, 2 and 3, which had a common α,β-unsaturated ketone moiety, exhibited conjugating abilities with GSH and also showed significant nitric oxide (NO) production inhibiting activities. The anti-inflammatory activities of compounds 1, 2 and 3 might be attributed to their targeting multiple cysteine residues on IKKβ; therefore, the alkylation of IKKβ by compound 1 was further studied by micrOTOF-MS.
The result showed that six cysteine residues (C(59), C(179), C(299), C(370), C(412), and C(618)) were alkylated, which indicated that IKKβ is a potential target for the anti-inflammatory activity of physalin A.
Physalin L Description
||The herbs of Physalis alkekengi
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(16):2103-5. |
|Investigation on quality standard of Franchet groundcherry.[Pubmed: 21046739]|
|To develop identification and assay methods of Franchet groundcherry.
METHODS AND RESULTS:
TLC method was used to identify of Physalin L in the sample using high performance silica gel G plate and a mixture of chloroform-acetone-methanol (25:1:1) as a developing solvent. In the chromatogram, Physalin L showed a distinct fluorescence spot under UV 365 nm with good separation. In the HPLC method, luteoloside was separated on a Venusil XBP C18 (4.6 mm x 250 mm, 5 microm) column with acetonitrile-0. 2% phosphoric acid (20:80) as the mobile phase with flow rate of 1 mL x min(-1). The detection wavelength was set at 350 nm.
For the HPLC quantitation method, the calibration curve of luteoloside displayed ideal linearity over the range of 0.50-249.40 mg x L(-1) with the regression equation of Y = 55,313X + 3.1641 (r = 1.000). The average recovery of luteoloside was 98.79% with a RSD of 1.1%. And the intra-day and inter-day precisions were less than 2%.
The TLC identification and HPLC determination were sensitive, reliable and repeatable and can be applied for the quality evaluation and assessment of Franchet Groundcherry Calyx.