ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $270.3 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Cytotechnology2022, s10616BMC Complement Altern Med....2019...Universidade Estadual Paulista...2017...J Chromatogr Sci.2020, 58(6):485-493.J Am Soc Mass Spectrom....2021...Genes Genomics.2020, 10.1007Sci Rep.2019, 9(1):6429Molecules.2021, 26(2):E255.
Lab Chip.2018, 18(6):971-978J of Applied Pharmaceutical Scien...2020...Int Immunopharmacol.2021, 100:108073. Arch Biochem Biophys.2020, 687:108384.Molecules.2019, 24(6):E1177Int J Mol Sci.2020, 21(8):2790.Nutrients.2019, 12(1)Chemistry of Natural Compounds...2018...
Acta Pharmaceutica Hungarica...2016...J Cell Physiol.2020, 10.1002J Anal Toxicol.2021, bkab015.Front. Physiol.2022, 790345.Anticancer Res.2018, 38(4):2127-2135Oncol Rep.2016, 35(3):1356-64J Drug Delivery Science and Tech....2022...
Our products had been exported to the following research institutions and universities, And still growing.
University of Fribourg (Switzerland)Funda??o Universitária de Dese... (Brazil)Anna University (India)Heidelberg University (Germany)
Florida International University (USA)Fraunhofer-Institut für Moleku... (Germany)St. Jude Children Research Hosp... (USA)University of Mysore (India)
Griffith University (Australia)Mendel University in Brno (Czech Republic)Universitas Airlangga (Indonesia)
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Molecules.2019, 24(23):E4303Tea Res. Ins. Of China2017, 1-12Polytechnic University of Catalonia2017, 105826J Bone Miner Res.2017, 32(12):2415-2430Sustainability2021, 13(23),12981.Biomolecules.2020, 10(2):E184Gene.2022, 815:146178.Phytomedicine.2020, 153440. Journal of Functional Foods2017, 30:30-38Plants2022, 11(3),294.
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Miscellaneous Compound Library
||Bidenoside C may have hepatoprotective activity.|
|Journal of Liquid Chromatography & Related Technologies, 2015, 38(19):1740-1746. |
|Pharmacokinetics of Five Different Types of Safflower Constituents in Rat Plasma after Oral Administration of Safflower Powder.[Reference: WebLink]|
|The petals of Carthamus tinctorius L. (safflower) is an important traditional medicine for promoting blood circulation and removing blood stasis. The pharmacokinetic properties of multiple safflower constituents have not been fully understood.
METHODS AND RESULTS:
In the present research, an ultra-high-performance liquid chromatography-triple quadrupole mass method in dynamic multiple reaction monitoring mode was developed and validated to simultaneously quantify in rat plasma of five different characteristic types of safflower constituents, including chalcone, poly-acetylene, glycoside of 6-hydroxykaempferol, etc. All the five constituents, hydroxysafflor yellow A, Bidenoside C, 6-hydroxykaempferol-3,6-diglucoside, chlorogenic acid, and p-coumaric acid were detected in rat plasma after oral administration of safflower powder. p-Coumaric acid was the most quickly absorbed one with Tmax of 0.1 hr. The poly-acetylene constituent, Bidenoside C, displayed the largest AUC0-t value (2177.796 ng · h/L) followed by hydroxysafflor yellow A (1564.1 ng · h/L).
The impressively favorable pharmacokinetic behavior of Bidenoside C reported herein for the first time rendered the importance for paying more attention to its role in the in vivo pharmacologic effects of safflower.
|BMC Complement Altern Med, 2016 Jun 13;16:179. |
|Hepato-protective effects and chemical constituents of a bioactive fraction of the traditional compound medicine-Gurigumu-7.[Pubmed: 27296281]|
|Gurigumu-7 is an important traditional Mongolian medicine frequently used for liver diseases. However, the pharmacological effects and the bioactive constituents are not well understood.
METHODS AND RESULTS:
This research was to use CCl4-induced liver damage in mice to investigate the hepatoprotective effects of Gurigumu-7 and the methanol eluted fraction from a DIAION column of an extract of Gurigumu-7 (MF). The chemical constituents of MF were analyzed by UPLC-MS.
Pretreated orally with MF (66, 132 and 264 mg/kg) once a day for 4 days dose-dependently suppressed CCl4-induced mice liver histopathological changes and serum aminotransferase activities (alanine transaminase: 1144.0 ± 787.2 v.s. 2461.8 ± 1072.7 U/L, p < 0.05; aspartate transaminase: 1173 ± 785.3 v.s. 2506.6 ± 1140.7 U/L, p < 0.01). MF treated group demonstrated increased levels of SOD (108.19 ± 30.32 v.s. 75.75 ± 5.37 U/mg protein, p < 0.01) but decreased levels of malonyldialdehyde (7.68 ± 1.95 v.s. 44.32 ± 16.68 nmol/mg protein, p < 0.01) compared to the CCl4 control group. More than 30 chemical constituents were quantified, and MF was found to be rich in ellagic acid (297.97 mg/g), luteolin and its glucosides (35.10 mg/g), apigenin and its glucosides (>30 mg/g), ursolic acid (14.91 mg/g), Bidenoside C (8.75 mg/g), and proanthocyanidins (15.64 mg/g in proanthocyanidin A2 equivalent).
The methanol eluted fraction (MF) from a DIAION column of an extract of the Mongolian medicine-Gurigumu-7 was found to be more hepatoprotective than Gurigumu-7. The results suggested that MF is a promising bioactive fraction for the development of new hepatoprotective medicine with better formulation and quality control properties.
Bidenoside C Description
||The herbs of Bidens pilosa
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.