ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $329.8 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Molecules.2018, 23(7):E1659Biomed Pharmacother.2019, 111:262-269Anat Rec2018, 24264Nutrients.2021, 13(3):978. Viruses.2021, 13(11):2118. J of Dentistry & Oral Health...2019...Toxicol In Vitro.2019, 59:161-178Korean J of Crop Science2019, 452-458
Journal of Ginseng Research...2021...Antioxidants2022, 11(2),234.BMC Complement Altern Med.2014, 14:242Neurotox Res.2020, 38(1):163-174.Evid Based Complement Alternat Me...2020...Med Sci Monit.2019, 25:9499-9508Appl. Sci.2020, 10(5),1713.Int J Pharm.2022, 618:121636.
J Pharmaceutical and Biomedical A...2022...Agronomy 2021, 11(3),502.African J. Agricultural Research ...2017...Food Res Int.2019, 123:125-134Asian Pac J Cancer Prev....2019...RSC Adv.2018, 32621-32636J Pharmaceutical Research Int....2021...
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Our products had been exported to the following research institutions and universities, And still growing.
Korea Food Research Institute(K... (Korea)VIT University (India)Celltrion Chemical Research Ins... (Korea)Helmholtz Zentrum München (Germany)
Chulalongkorn University (Thailand)University of Minnesota (USA)Shanghai Institute of Organic C... (China)Calcutta University (India)
Institute of Tropical Disease U... (Indonesia)Universidad Veracuzana (Mexico)Max-Planck-Insitut (Germany)
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Ganoderenic acid D
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manager@chemfaces.com
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service@chemfaces.com
Tel:
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Fax:
+86-27-84254680
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Plant Biotechnology Reports 2021, 15:117-124.Clin Transl Oncol.2019, 10.1007Cytotechnology.2017, 69(5):765-773BMC Complement Altern Med.2014, 14:242Asian Pac J Cancer Prev.2021, 22(S1):97-106.J of Food Quality2020, 8851285.Food Sci Biotechnol.2021, 30(2):217-226.Nat Prod Sci.2016, 22(2)Biochem Biophys Res Commun.2020, 522(4):1052-1058Journal of Ginseng Research2019, 10.1016
Related Screening Libraries
| Description: |
Ganoderenic acid D is most cytotoxic with IC50 values of 0.14 ± 0.01, 0.18 ± 0.02 and 0.26 ± 0.03 mg/mL in Hep G2, Hela and Caco-2 cells, respectively. |
Ganoderenic acid D Description
| Source: |
The fruit body of Ganoderma lucidum. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.9507 mL |
9.7534 mL |
19.5069 mL |
39.0137 mL |
48.7672 mL |
| 5 mM |
0.3901 mL |
1.9507 mL |
3.9014 mL |
7.8027 mL |
9.7534 mL |
| 10 mM |
0.1951 mL |
0.9753 mL |
1.9507 mL |
3.9014 mL |
4.8767 mL |
| 50 mM |
0.039 mL |
0.1951 mL |
0.3901 mL |
0.7803 mL |
0.9753 mL |
| 100 mM |
0.0195 mL |
0.0975 mL |
0.1951 mL |
0.3901 mL |
0.4877 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Natural Product Research, Volume 28, Number 24, 17 December 2014, pp. 2264-2272(9) | | Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth[Reference: WebLink] | The response surface methodology was used to optimise the extraction conditions of Ganoderma lucidum based on a Box–Behnken design.
METHODS AND RESULTS:
A quadratic model sufficiently simulated the response of ganoderic acid H with a determination coefficient (R 2) of 0.98. The optimal condition for extracting triterpenoids was determined to be 100.00% ethanol at 60.22°C for 6.00 h, under which the yield of the reference triterpenoid ganoderic acid H increased from 0.88 to 2.09 mg/g powder. Following extraction, triterpenoid-enriched fraction was further isolated into 23 fractions, and 7 fractions were identified as ganoderic acids A, B, D, G, H and I and Ganoderenic acid D. Of the seven triterpenoids, Ganoderenic acid D was most cytotoxic with IC50 values of 0.14 ± 0.01, 0.18 ± 0.02 and 0.26 ± 0.03 mg/mL in Hep G2, Hela and Caco-2 cells, respectively. While ganoderic acids A, G and H were relatively non-cytotoxic.
CONCLUSIONS:
The variation of inhibitory effects for these triterpenoids was likely related to their chemical structures. |
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