ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
3. Inhibitors
Citing Use of our Products
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Tel: (0086)-27-84237683
Fax: (0086)-27-84254680
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $329.8 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Asian Journal of Chemistry...2014...Phytother Res.2015, 29(7):1088-96Proc Natl Acad Sci USA....2016...SBRAS2016, 12Korean J. of Food Sci. and Tech...2016...Br J Pharmacol.2016, 173(2):396-410J Basic Clin Physiol Pharmacol....2016...Hum Exp Toxicol.2017, 36(11):1169-1176
Integr Med Res.2017, 6(4):395-403Chem Pharm Bull (Tokyo)....2017...Industrial Crops and Products...2017...Nutrients.2018, 10(12)Int J Mol Sci.2018, 19(2)Oncology Letters2018, 4690-4696Nutr Res Pract2019, 13:e45Chemistry of Plant Materials....2019...
Pak J Pharm Sci.2019, 32(6)Appl Biochem Biotechnol....2020...Drug Chem Toxicol.2020, 1-14. Research J. Pharm. and Tech....2020...Oxid Med Cell Longev....2020...American Association for Anatomy...2020...Natural Product Communications...2020...
More...
Our products had been exported to the following research institutions and universities, And still growing.
University of Parma (Italy)Universiti Malaysia Pahang (Malaysia)Max-Planck-Insitut (Germany)Universidad Veracuzana (Mexico)
University of Perugia (Italy)University of Malaya (Malaysia)John Innes Centre (United Kingdom)National Cancer Center Research... (Japan)
Universidade do Porto (Portugal)Korea Food Research Institute(K... (Korea)University of Madras (India)
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Ganoderenic acid D
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Antioxidants (Basel).2020, 9(6):466.Nat Commun.2019, 10(1):5169The Journal of Internal Korean Medicine2015, 36(4):486-497J Pharmaceut Biomed2020, 182:113110Front Pharmacol.2020, 11:251.Antioxidants (Basel).2019, 8(8):E307Phytochemistry2018, 15:83-92FASEB J.2019, 33(2):2026-2036Journal of Food Hygiene and Safety2019, 34(5):413-420Biochem Biophys Res Commun.2019, 518(4):732-738
Related Screening Libraries
| Description: |
Ganoderenic acid D is most cytotoxic with IC50 values of 0.14 ± 0.01, 0.18 ± 0.02 and 0.26 ± 0.03 mg/mL in Hep G2, Hela and Caco-2 cells, respectively. |
Ganoderenic acid D Description
| Source: |
The fruit body of Ganoderma lucidum. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.9507 mL |
9.7534 mL |
19.5069 mL |
39.0137 mL |
48.7672 mL |
| 5 mM |
0.3901 mL |
1.9507 mL |
3.9014 mL |
7.8027 mL |
9.7534 mL |
| 10 mM |
0.1951 mL |
0.9753 mL |
1.9507 mL |
3.9014 mL |
4.8767 mL |
| 50 mM |
0.039 mL |
0.1951 mL |
0.3901 mL |
0.7803 mL |
0.9753 mL |
| 100 mM |
0.0195 mL |
0.0975 mL |
0.1951 mL |
0.3901 mL |
0.4877 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Natural Product Research, Volume 28, Number 24, 17 December 2014, pp. 2264-2272(9) | | Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth[Reference: WebLink] | The response surface methodology was used to optimise the extraction conditions of Ganoderma lucidum based on a Box–Behnken design.
METHODS AND RESULTS:
A quadratic model sufficiently simulated the response of ganoderic acid H with a determination coefficient (R 2) of 0.98. The optimal condition for extracting triterpenoids was determined to be 100.00% ethanol at 60.22°C for 6.00 h, under which the yield of the reference triterpenoid ganoderic acid H increased from 0.88 to 2.09 mg/g powder. Following extraction, triterpenoid-enriched fraction was further isolated into 23 fractions, and 7 fractions were identified as ganoderic acids A, B, D, G, H and I and Ganoderenic acid D. Of the seven triterpenoids, Ganoderenic acid D was most cytotoxic with IC50 values of 0.14 ± 0.01, 0.18 ± 0.02 and 0.26 ± 0.03 mg/mL in Hep G2, Hela and Caco-2 cells, respectively. While ganoderic acids A, G and H were relatively non-cytotoxic.
CONCLUSIONS:
The variation of inhibitory effects for these triterpenoids was likely related to their chemical structures. |
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