Science | Nature | Cell | View More
Natural Products
Broussonin A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Broussonin A
Price:
CAS No.: 73731-87-0
Catalog No.: CFN97694
Molecular Formula: C16H18O3
Molecular Weight: 258.32 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The branches of Broussonetia papyrifera
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Leibniz-Institut für Pflanzenb... (Germany)
  • University of Helsinki (Finland)
  • Medical University of Gdansk (Poland)
  • Uniwersytet Jagielloński w Kra... (Poland)
  • University of Virginia (USA)
  • Korea Institute of Oriental Med... (Korea)
  • University Medical Center Mainz (Germany)
  • Agricultural Research Organizat... (Israel)
  • University of Brasilia (Brazil)
  • Universiti Sains Malaysia (Malaysia)
  • National Chung Hsing University (Taiwan)
  • More...
Package
Featured Products
Pseudoaspidin

Catalog No: CFN90684
CAS No: 478-28-4
Price: $138/20mg
Eurycomanone

Catalog No: CFN92008
CAS No: 84633-29-4
Price: $268/20mg
Vincristine sulfate

Catalog No: CFN90400
CAS No: 2068-78-2
Price: $138/20mg
3',4',5'-Trimethoxyflavone

Catalog No: CFN70439
CAS No: 67858-30-4
Price: $118/10mg
(-)-Asarinin

Catalog No: CFN90144
CAS No: 133-04-0
Price: $128/20mg
Bergapten

Catalog No: CFN98766
CAS No: 484-20-8
Price: $40/20mg
Astrasieversianin VII

Catalog No: CFN90648
CAS No: 86764-11-6
Price: $238/10mg
Diosmin

Catalog No: CFN98145
CAS No: 520-27-4
Price: $30/20mg
Piceatannol

Catalog No: CFN99024
CAS No: 10083-24-6
Price: $40/20mg
20-O-Glucoginsenoside Rf

Catalog No: CFN95036
CAS No: 68406-27-9
Price: $318/5mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A can significantly inhibit adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay; it suppresses lipopolysaccharide (LPS)-stimulated inducible nitric oxide synthase (iNOS) expression at the transcriptional level through modulating NF-κB and down-regulation of the Akt and ERK signaling pathways.
Targets: NOS | Akt | ERK | Estrogen receptor | IFN-γ | IL Receptor | NF-kB | IkB | IKK | Progestogen receptor
In vitro:
Chem Biodivers. 2014 May;11(5):749-59.
Suppression of inducible nitric oxide synthase expression by nyasol and broussonin A, two phenolic compounds from Anemarrhena asphodeloides, through NF-κB transcriptional regulation in vitro and in vivo.[Pubmed: 24827684]
Anemarrhena asphodeloides is widely used in traditional Chinese medicine, and is known to possess antidiabetic and anti-inflammatory properties.
METHODS AND RESULTS:
Because inducible nitric oxide synthase (iNOS) plays an important role in inflammation, we investigated the inhibitory effects of two known phenolic compounds, nyasol (1) and Broussonin A (2), from A. asphodeloides, on iNOS and its plausible mechanism of action. Compounds 1 and 2 exhibited inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Compounds 1 and 2 also suppressed the expressions of iNOS protein and mRNA. Moreover, compounds 1 and 2 suppressed the expression of inflammatory cytokines such as interleukin-1β (IL-1β) and interferon-β (IFN-β). They also inhibited the transcriptional activity of NF-κB and degradation of IκB-α, as well as the activation of Akt and ERK in LPS-stimulated RAW 264.7 cells. In in vivo animal model, compounds 1 and 2 significantly inhibited TPA-induced mouse ear edema.
CONCLUSIONS:
These results suggest that 1 and 2 suppress LPS-stimulated iNOS expression at the transcriptional level through modulating NF-κB and down-regulation of the Akt and ERK signaling pathways. Taken together, these findings indicate that the suppressive effects of 1 and 2 on iNOS expression might provide one possible mechanism for their anti-inflammatory activities.
Bioorg Med Chem Lett. 2010 Jun 15;20(12):3764-7.
New estrogenic compounds isolated from Broussonetia kazinoki.[Pubmed: 20493686 ]

METHODS AND RESULTS:
Two new and two known compounds were identified as estrogenic constituents from Broussonetia kazinoki. Their structures were elucidated as Broussonin A (1), tupichinol C (2), kazinol U (3), and (+)-(2R) kazinol I (4).
CONCLUSIONS:
They showed estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. They also control the cellular gene expression levels of estrogen-responsive genes. Phytoestrogens from B. kazinoki may have beneficial effects in the treatment of menopausal symptoms.
Broussonin A Description
Source: The branches of Broussonetia papyrifera
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Benzyl beta-D-glucopyranoside

Catalog No: CFN95427
CAS No: 4304-12-5
Price: $318/10mg
Scutellarein-7-O-glucoside

Catalog No: CFN95082
CAS No: 26046-94-6
Price: $318/5mg
Cichoriin

Catalog No: CFN95196
CAS No: 531-58-8
Price: $100/20mg
8'-O-(3-hydroxy-3-methylglutaryl)-...

Catalog No: CFN95308
CAS No: 69790-31-4
Price: $318/5mg
Lonicerin

Catalog No: CFN95055
CAS No: 25694-72-8
Price: $168/10mg
10-Deacetylcephalomannine

Catalog No: CFN95519
CAS No: 76429-85-1
Price: $318/10mg
Eriodictyol 7-O-glucuronide

Catalog No: CFN95290
CAS No: 125535-06-0
Price: $318/10mg
Oxytroflavoside B

Catalog No: CFN95490
CAS No: 1391144-81-2
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.8712 mL 19.3558 mL 38.7117 mL 77.4234 mL 96.7792 mL
5 mM 0.7742 mL 3.8712 mL 7.7423 mL 15.4847 mL 19.3558 mL
10 mM 0.3871 mL 1.9356 mL 3.8712 mL 7.7423 mL 9.6779 mL
50 mM 0.0774 mL 0.3871 mL 0.7742 mL 1.5485 mL 1.9356 mL
100 mM 0.0387 mL 0.1936 mL 0.3871 mL 0.7742 mL 0.9678 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Bioorg Med Chem Lett. 2012 Apr 15;22(8):2760-3.
A new pancreatic lipase inhibitor from Broussonetia kanzinoki.[Pubmed: 22450131]

METHODS AND RESULTS:
A new phenolic compound, broussonone A (1) were isolated from the stem barks of Broussonetia kanzinoki (Moraceae), together with two diphenylpropanes, Broussonin A (2), broussonin B (3), two flavans, 7,4'-dihydroxyflavan (4), 3',7-dihydroxy-4'-methoxyflavan (5), and two flavones, 3,7-dihydroxy-4'-methoxyflavone (6), 3,7,3'-trihydroxy-4'-methoxyflavone (7).
CONCLUSIONS:
Compound 1 showed noncompetitive inhibitory activity on pancreatic lipase with an IC(50) of 28.4 μM. In addition, compounds 1-5 significantly inhibited adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay.
Structure Identification:
Chemistry Letters,1980,3(3):339-340.
Broussonins A and B, new phytoalexins from diseased paper mulberry.[Reference: WebLink]

METHODS AND RESULTS:
Isolation and structure elucidation of two phytoalexins (1 and 2), produced by diseased paper mulberry and designated as Broussonin A and broussonin B, are described.
CONCLUSIONS:
These phytoalexins are characterized structurally by a 1,3-diphenylpropane skeleton.
Pseudoaspidin

Catalog No: CFN90684
CAS No: 478-28-4
Price: $138/20mg
Eurycomanone

Catalog No: CFN92008
CAS No: 84633-29-4
Price: $268/20mg
Vincristine sulfate

Catalog No: CFN90400
CAS No: 2068-78-2
Price: $138/20mg
3',4',5'-Trimethoxyflavone

Catalog No: CFN70439
CAS No: 67858-30-4
Price: $118/10mg
(-)-Asarinin

Catalog No: CFN90144
CAS No: 133-04-0
Price: $128/20mg
Bergapten

Catalog No: CFN98766
CAS No: 484-20-8
Price: $40/20mg
Astrasieversianin VII

Catalog No: CFN90648
CAS No: 86764-11-6
Price: $238/10mg
Diosmin

Catalog No: CFN98145
CAS No: 520-27-4
Price: $30/20mg
Piceatannol

Catalog No: CFN99024
CAS No: 10083-24-6
Price: $40/20mg
20-O-Glucoginsenoside Rf

Catalog No: CFN95036
CAS No: 68406-27-9
Price: $318/5mg
Tags: buy Broussonin A | Broussonin A supplier | purchase Broussonin A | Broussonin A cost | Broussonin A manufacturer | order Broussonin A | Broussonin A distributor