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3. Inhibitors
Silychristin B
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $318 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
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Silychristin B
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Int J Med Sci.2020, 17(5):626-631Curr Res Virol Sci.2022, 3:100019.Antioxidants (Basel).2021, 10(8):1300. Appl. Sci.2020, 10(20),7374.Neuropharmacology2019, 151437Acta Chromatographica2016, 29(3)Molecules.2019, 24(4):E709Journal of Plant Growth Regulation2022, 10705-2.African J. Agricultural Research 2017, 12(13):1164-1168Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Flavonoids Compound Library |
| Description: |
Reference standards. |
Silychristin B Description
| Source: |
The herbs of Silybum marianum (L.) Gaertn. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.073 mL |
10.3648 mL |
20.7297 mL |
41.4594 mL |
51.8242 mL |
| 5 mM |
0.4146 mL |
2.073 mL |
4.1459 mL |
8.2919 mL |
10.3648 mL |
| 10 mM |
0.2073 mL |
1.0365 mL |
2.073 mL |
4.1459 mL |
5.1824 mL |
| 50 mM |
0.0415 mL |
0.2073 mL |
0.4146 mL |
0.8292 mL |
1.0365 mL |
| 100 mM |
0.0207 mL |
0.1036 mL |
0.2073 mL |
0.4146 mL |
0.5182 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| International Journal of Mass Spectrometry, 2012, 315(1):46-54. | | Collision induced dissociation study of the major components of silymarin.[Reference: WebLink] | The fragmentation properties of the major silymarin constituents, including silydianin, silychristin A and Silychristin B
, silybin A and B and isosilybin A and B were studied by energy-dependent collision-induced dissociation (CID) technique.
METHODS AND RESULTS:
The survival yield (SY) method was applied to compare the fragmentation behavior of the various silymarin components. MS/MS spectra were recorded at collision energies which correspond to about 50% survival yield (CE50) and about 1% survival yield (CE01). The laboratory frame collision energy dependence of the fragmentation was studied on the basis of the breakdown curves, i.e., the relative intensities of fragment ions versus collision energy.
CONCLUSIONS:
The fragmentation of silybins and isosilybins is distinct in spite of the minimal difference between their structures. This phenomenon, which is the basis of their analytical identification, is explained in details for the first time, on the basis of the energy-dependent MS/MS experiments and the conformational analysis. |
|
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