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    Natural Products
    Chamigrenol
    Chamigrenol
    Information
    CAS No. 19822-80-1 Price $318 / 10mg
    Catalog No.CFN95247Purity>=98%
    Molecular Weight220.35Type of CompoundSesquiterpenoids
    FormulaC15H24OPhysical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $144.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Chamigrenol

    Chamigrenol
    Product Name Chamigrenol
    CAS No.: 19822-80-1
    Catalog No.: CFN95247
    Molecular Formula: C15H24O
    Molecular Weight: 220.35 g/mol
    Purity: >=98%
    Type of Compound: Sesquiterpenoids
    Physical Desc.: Powder
    Targets: ATPase | Sodium Channel | Potassium Channel | Antifection
    Source: The fruits of Schisandra chinensis.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $318 / 10mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Sesquiterpenoids Compound Library
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  • Biological Activity
    Description: Chamigrenol is a promising candidate for the development of potent Na+/K+ ATPase inhibitors and antimicrobial agents. It inhibited the activities of Na+/K+-ATPase, with the IC50 value of 15.9 ± 0.54 μg/mL.
    Targets: ATPase | Sodium Channel | Potassium Channel | Antifection
    In vitro:
    Archives of pharmacal research, 2011, 34(12):2141-2147.
    In vitro Na+/K+-ATPase inhibitory activity and antimicrobial activity of sesquiterpenes isolated from Thujopsis dolabrata.[Reference: WebLink]

    METHODS AND RESULTS:
    A series of sesquiterpenes and hinokitiol-related compounds (1–15) was isolated from the essential oil of Thujopsis dolabrata Sieb. et Zucc. var. hondai Makino, and their structures were determined by combined spectroscopic analyses. The inhibitory effects of these compounds on microbial cell growth and Na+/K+-ATPase were evaluated in vitro. It was found that (−)-elema-1,3,11(13)-trien-12-ol (5), α,β,γ-costol (8), and Chamigrenol (11) inhibit the activities of Na+/K+-ATPase, with IC50 values of 11.2 ± 0.11, 12.2 ± 0.09, and 15.9 ± 0.54 μg/mL, respectively. Thujopsene (1), cedrol (9), γ-cuparenol (10), and Chamigrenol (11) showed potent antibacterial activity, with MIC values in the range of 25–50 μg/mL, and β-thujaplicin (12) exhibited a broad spectrum of antibacterial and antifungal activity.
    CONCLUSIONS:
    These results indicate that these isolated compounds are promising candidates for the development of potent Na+/K+ ATPase inhibitors and antimicrobial agents.
    Chamigrenol Description
    Source: The fruits of Schisandra chinensis.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.5382 mL 22.6912 mL 45.3823 mL 90.7647 mL 113.4559 mL
    5 mM 0.9076 mL 4.5382 mL 9.0765 mL 18.1529 mL 22.6912 mL
    10 mM 0.4538 mL 2.2691 mL 4.5382 mL 9.0765 mL 11.3456 mL
    50 mM 0.0908 mL 0.4538 mL 0.9076 mL 1.8153 mL 2.2691 mL
    100 mM 0.0454 mL 0.2269 mL 0.4538 mL 0.9076 mL 1.1346 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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