ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
3. Inhibitors
Chamigrenol
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $144.7 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Molecules.2021, 26(16):4722.Bioorg Med Chem.2018, 26(14):4201-4208Chem. of Vegetable Raw Materials...2020...Gene.2022, 815:146178.BMC Complement Altern Med....2018...Enzyme Microb Technol....2022...Korean J Acupunct2020, 37:104-121Metabolites2023, 13(1), 3.
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Chamigrenol
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manager@chemfaces.com
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service@chemfaces.com
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Fax:
+86-27-84254680
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Chem Biol Interact.2019, 315:108910Pol J Microbiol.2021, 70(1):117-130.Am J Chin Med.2015, 30:1-22BMB Rep.2018, 51(5):249-254J Applied Biological Chemistry2021, 64(2):185-192Pharmaceutics.2020, 12(9):882. The Catharanthus Genome2022,35-83.Mol Pharmacol.2021, 99(2):163-174.Int. J. Mol. Sci.2022, 23(14),7699; Int J Mol Sci.2019, 20(23):E6071
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
Chamigrenol is a promising candidate for the development of potent Na+/K+ ATPase inhibitors and antimicrobial agents. It inhibited the activities of Na+/K+-ATPase, with the IC50 value of 15.9 ± 0.54 μg/mL. |
| Targets: |
ATPase | Sodium Channel | Potassium Channel | Antifection |
| In vitro: |
| Archives of pharmacal research, 2011, 34(12):2141-2147. | | In vitro Na+/K+-ATPase inhibitory activity and antimicrobial activity of sesquiterpenes isolated from Thujopsis dolabrata.[Reference: WebLink] |
METHODS AND RESULTS:
A series of sesquiterpenes and hinokitiol-related compounds (1–15) was isolated from the essential oil of Thujopsis dolabrata Sieb. et Zucc. var. hondai Makino, and their structures were determined by combined spectroscopic analyses. The inhibitory effects of these compounds on microbial cell growth and Na+/K+-ATPase were evaluated in vitro. It was found that (−)-elema-1,3,11(13)-trien-12-ol (5), α,β,γ-costol (8), and Chamigrenol (11) inhibit the activities of Na+/K+-ATPase, with IC50 values of 11.2 ± 0.11, 12.2 ± 0.09, and 15.9 ± 0.54 μg/mL, respectively. Thujopsene (1), cedrol (9), γ-cuparenol (10), and Chamigrenol (11) showed potent antibacterial activity, with MIC values in the range of 25–50 μg/mL, and β-thujaplicin (12) exhibited a broad spectrum of antibacterial and antifungal activity.
CONCLUSIONS:
These results indicate that these isolated compounds are promising candidates for the development of potent Na+/K+ ATPase inhibitors and antimicrobial agents. |
|
Chamigrenol Description
| Source: |
The fruits of Schisandra chinensis. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
4.5382 mL |
22.6912 mL |
45.3823 mL |
90.7647 mL |
113.4559 mL |
| 5 mM |
0.9076 mL |
4.5382 mL |
9.0765 mL |
18.1529 mL |
22.6912 mL |
| 10 mM |
0.4538 mL |
2.2691 mL |
4.5382 mL |
9.0765 mL |
11.3456 mL |
| 50 mM |
0.0908 mL |
0.4538 mL |
0.9076 mL |
1.8153 mL |
2.2691 mL |
| 100 mM |
0.0454 mL |
0.2269 mL |
0.4538 mL |
0.9076 mL |
1.1346 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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