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Clerosterol glucoside
Clerosterol glucoside
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Clerosterol glucoside
Price:
CAS No.: 123621-00-1
Catalog No.: CFN99351
Molecular Formula: C35H58O6
Molecular Weight: 574.8 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The fresh fruits of Momordica charantia L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Clerosterol exerts its cytotoxic effect in A2058 human melanoma cells by caspases-dependent apoptosis.
Clerosterol glucoside Description
Source: The fresh fruits of Momordica charantia L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7397 mL 8.6987 mL 17.3974 mL 34.7947 mL 43.4934 mL
5 mM 0.3479 mL 1.7397 mL 3.4795 mL 6.9589 mL 8.6987 mL
10 mM 0.174 mL 0.8699 mL 1.7397 mL 3.4795 mL 4.3493 mL
50 mM 0.0348 mL 0.174 mL 0.3479 mL 0.6959 mL 0.8699 mL
100 mM 0.0174 mL 0.087 mL 0.174 mL 0.3479 mL 0.4349 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Cell Research:
Marine Drugs, 2013, 11(2):418-430.
Cytotoxic Effect of Clerosterol Isolated from Codium fragile on A2058 Human Melanoma Cells.[Reference: WebLink]

METHODS AND RESULTS:
The cytotoxic effects and mechanism of action of clerosterol(Clerosterol glucoside), isolated from the marine alga Codium fragile, were investigated in A2058 human melanoma cells. Clerosterol inhibited the growth of A2058 cells with an IC50 of 150 µM and induced apoptotic cell death, as evidenced by DNA fragmentation, an increase in the number of sub-G1 hypodiploid cells and the presence of apoptotic bodies. Clerosterol treatment caused the loss of mitochondrial membrane potential. Alterations in the expression of apoptosis-associated proteins in response to clerosterol treatment included upregulation of Bax, downregulation of Bcl-2 and activation of caspases 3 and 9. The pan-caspase inhibitor treatment attenuated the expression of the active form of caspases and cell death induced by clerosterol.
CONCLUSIONS:
The present results show that clerosterol exerts its cytotoxic effect in A2058 human melanoma cells by caspases-dependent apoptosis.
CFN99351Clerosterol glucoside123621-00-1574.8 C35H58O6
CFN9948022-Dehydroclerosterol glucoside143815-99-0572.8 C35H56O6
CFN98000Stigmasterol glucoside19716-26-8574.8 C35H58O6
CFN98713Daucosterol474-58-8576.9 C35H60O6
CFN99866Sitoindoside I18749-71-8815.3 C51H90O7
CFN99217Ikshusterol 3-O-glucoside112137-81-2592.9 C35H60O7
CFN99824alpha-Spinasterol glucoside1745-36-4574.8 C35H58O6
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