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3. Inhibitors
Conduritol A
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $92.2 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
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Conduritol A
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LWT2020, 110397J Cancer.2019, 10(23):5843-5851Recent Pat Anticancer Drug Discov.2022, 17(4):416-426.Korean Journal of Pharmacognosy2018, 49(3):270-277National Academy Science Letters2023, s40009.J Cell Mol Med.2018, 22(9):4236-4242J Nat Med.2020, 74(3):550-560.Molecules.2019, 24(16):E3003Plant Direct.2021, 5(12):e372. Processes2021, 9(1), 153;
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
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| Description: |
Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function; it also can markedly prevent the diabetic rats from getting cataracts through the inhibition of lens aldose reductase.
|
| Targets: |
TNF-α | Lens aldose reductase |
| In vivo: |
| Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(24):2961-5. | | Experimental [corrected] study of hypoglycemic activity of conduritol A of stems of Gymnema sylvestre[Pubmed: 19294862] | To investigates the mechanism of hypooglycemic effect of Conduritol A of stems of Gymnema sylvestre.
METHODS AND RESULTS:
Fourteen days later after administration, observation is taken on the change of these mice and rats weight, the FBG, TG, CHO, SOD, MDA, INS, TNF in serum were also detected with enzymology method and Radioimmuoassay method. Take the liver to determine the disposal of glucose. Take the pancreas to do the HE and immunohistochemistrial staining, and show pancreas islet beta-cell. Calulate thymus, pancreas, splenica index.
Compared with diabetic model mice, high and middosage of Conduritol A could remarkably reduce fasted blood sugar in diabetic rats induced by alloxan (P < 0.01). Significantly increase the level of serum insulin (P < 0.05). Activity of SOD was obviously increased, and amount of MDA was obviously decreased (P < 0.05). The amount of Conduritol A disposal of glucose was obviously increased (P < 0.05). Significantly increase thymus, pancreas, splencia index (P < 0.01 or 0.05); inhibited the atrophy of thymus, pancreas, splencias of the diabetic rats induced by alloxan. Compared with diabetic model group, cell structure and form of Conduritol A had been some way improved. The immunohistochemistry results showed that beta-cells numbers of pancreas in each Conduritol A group were more than those in the model group.
CONCLUSIONS:
Conduritol A could have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function. Promoting synthesis of hepatic to decrease fasted blood suger. |
|
Conduritol A Description
| Source: |
The barks of Marsdenia condurango |
| Solvent: |
DMSO, Pyridine, Methanol, Ethanol, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
6.8446 mL |
34.2231 mL |
68.4463 mL |
136.8925 mL |
171.1157 mL |
| 5 mM |
1.3689 mL |
6.8446 mL |
13.6893 mL |
27.3785 mL |
34.2231 mL |
| 10 mM |
0.6845 mL |
3.4223 mL |
6.8446 mL |
13.6893 mL |
17.1116 mL |
| 50 mM |
0.1369 mL |
0.6845 mL |
1.3689 mL |
2.7379 mL |
3.4223 mL |
| 100 mM |
0.0684 mL |
0.3422 mL |
0.6845 mL |
1.3689 mL |
1.7112 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Animal Research: |
| Biosci.Biotech. Biochem.,1994, 58(4):756-7. | | Effect of Conduritol A, a Polyol from Gymnema sylvestre, on the Development of Diabetic Cataracts in Streptozotocin-treated Rats and on Aldose Reductase.[Reference: WebLink] |
METHODS AND RESULTS:
Streptozotocin-diabetic rats were maintained on a stock diet for 16 weeks and some were given Conduritol A (10 mg/kg/day). The administration of Conduritol A, having a hypoglycemic effect, markedly prevented the diabetic rats from getting cataracts. In practice, Conduritol A inhibited aldose reductase (EC 1.1.1.21) that is capable of catalyzing the conversion of aldoses to sugar alcohols in the polyol pathway. In an in vitro assay, lens aldose reductase was most effectively inhibited by Conduritol A when α,β-d-glucose was used as a substrate. Some enzymes from the rats were not inhibited by Conduritol A. Neither an intraperitoneal injection nor oral dosage of Conduritol A caused acute toxicity in the rats.
CONCLUSIONS:
These findings suggest that the inhibition of lens aldose reductase by Conduritol A may be responsible for its cataract-suppressing effect.
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