Cucurbitacin B 2-O-beta-D-glucoside | CAS:65247-27-0

Cucurbitacin B 2-O-beta-D-glucoside

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Description:

Cucurbitacin B 2-o-β-D-glucoside has anticancer activity.

In vitro:

Bioprocess Biosyst Eng. 2016 Sep;39(9):1435-40.

A biotransformation process for the production of cucurbitacin B from its glycoside using a selected Streptomyces sp.[Pubmed: 27145940 ]

Cucurbitacin B (CuB) and its glycoside, Cucurbitacin B 2-O-beta-D-glucoside (CuBg), abundantly occur in the pedicels of Cucumis melo. Compared with CuB, CuBg is not efficiently extracted from the pedicels. Furthermore, the anticancer activity of CuBg is lower than that of the aglycone.
METHODS AND RESULTS:
A process for CuBg biotransformation to CuB was developed for the first time. A strain of Streptomyces species that converts CuBg into CuB was isolated from an enrichment culture of C. melo pedicels. After optimization of conditions for enzyme production and biotransformation, a maximum conversion rate of 92.6 % was obtained at a CuBg concentration of 0.25 g/L. When biotransformation was performed on C. melo pedicel extracts, the CuB concentration in the extracts increased from 1.50 to 3.27 g/L. The conversion rate was almost 100 %.
CONCLUSIONS:
The developed process may be an effective biotransformation method for industrial production CuB from C. melo pedicels for pharmaceuticals.

Cucurbitacin B 2-O-beta-D-glucoside Description

Source:	The rhizomes of Hemsleya amabilis Diels.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Cucurbitacin B 2-O-beta-D-glucoside
Price:
CAS No.:	65247-27-0
Catalog No.:	CFN92141
Molecular Formula:	C₃₈H₅₆O₁₃
Molecular Weight:	720.9 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The rhizomes of Hemsleya amabilis Diels.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3872 mL	6.9358 mL	13.8715 mL	27.7431 mL	34.6789 mL
5 mM	0.2774 mL	1.3872 mL	2.7743 mL	5.5486 mL	6.9358 mL
10 mM	0.1387 mL	0.6936 mL	1.3872 mL	2.7743 mL	3.4679 mL
50 mM	0.0277 mL	0.1387 mL	0.2774 mL	0.5549 mL	0.6936 mL
100 mM	0.0139 mL	0.0694 mL	0.1387 mL	0.2774 mL	0.3468 mL

CFN90324	Cucurbitacin A	6040-19-3	574.71	C₃₂H₄₆O₉
CFN70316	Cucurbitacin I	2222-07-3	514.7	C₃₀H₄₂O₇
CFN90154	Cucurbitacin E	18444-66-1	556.67	C₃₂H₄₄O₈
CFN90535	Cucurbitacin S	60137-06-6	498.65	C₃₀H₄₂O₆
CFN92892	Tetrahydroisocucurbitacin I	3877-89-2	518.68	C₃₀H₄₆O₇
CFN98171	Cucurbitacin IIA	58546-34-2	562.73	C₃₂H₅₀O₈
CFN91760	Cucurbitacin Q1	99530-82-2	560.72	C₃₂H₄₈O₈
CFN92895	Cucurbitacin R	55903-92-9	518.68	C₃₀H₄₆O₇
CFN92140	Dihydrocucurbitacin B	13201-14-4	560.7	C₃₂H₄₈O₈
CFN91586	Fabacein	37710-13-7	600.7	C₃₄H₄₈O₉