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    Natural Products
    Physalin O
    Physalin O
    Information
    CAS No. 120849-18-5 Price $413 / 5mg
    Catalog No.CFN95097Purity>=95%
    Molecular Weight528.55Type of CompoundSteroids
    FormulaC28H32O10Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $475.0 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Physalin O

    Physalin O
    Product Name Physalin O
    CAS No.: 120849-18-5
    Catalog No.: CFN95097
    Molecular Formula: C28H32O10
    Molecular Weight: 528.55 g/mol
    Purity: >=95%
    Type of Compound: Steroids
    Physical Desc.: Powder
    Targets: IKK
    Source: The herbs of Physalis alkekengi
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $413 / 5mg
    Inquire / Order: manager@chemfaces.com
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  • Front Pharmacol.2020, 11:683.
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Steroids Compound Library
  • IKK Inhibitor Library
  • Biological Activity
    Description: Physalin O possesses anti-inflammatory activity, it exhibited conjugating abilities with GSH and also showed significant nitric oxide (NO) production inhibiting activities.
    Targets: IKK
    In vitro:
    Steroids. 2012 Apr;77(5):441-7.
    Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors.[Pubmed: 22197662 ]
    Michael reaction acceptors (MRAs) are a class of active molecules that are directly or indirectly involved in various cellular processes, including the regulation of many signaling pathways. In this study, the inducible nitric oxide synthase (iNOS) assay was used to demonstrate that the dichloromethane extract of Physalis alkekengi var. franchetii (DCEP) possesses anti-inflammatory activity that might be attributed to the modification of key cysteine residues in IKKβ by the MRAs in DCEP.
    METHODS AND RESULTS:
    To isolate these MRAs, glutathione (GSH) was employed, and a simple ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) screening method was developed to investigate the GSH conjugates with potential MRAs. Five physalins, including one new compound isophysalin A (2), together with four known steroidal compounds, physalin A (1), Physalin O (3), physalin L (4) and physalin G (5), were isolated to evaluate the GSH conjugating abilities, and it was indicated that compounds 1, 2 and 3, which had a common α,β-unsaturated ketone moiety, exhibited conjugating abilities with GSH and also showed significant nitric oxide (NO) production inhibiting activities.
    CONCLUSIONS:
    The anti-inflammatory activities of compounds 1, 2 and 3 might be attributed to their targeting multiple cysteine residues on IKKβ; therefore, the alkylation of IKKβ by compound 1 was further studied by micrOTOF-MS. The result showed that six cysteine residues (C(59), C(179), C(299), C(370), C(412), and C(618)) were alkylated, which indicated that IKKβ is a potential target for the anti-inflammatory activity of physalin A.
    Physalin O Description
    Source: The herbs of Physalis alkekengi
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.892 mL 9.4598 mL 18.9197 mL 37.8394 mL 47.2992 mL
    5 mM 0.3784 mL 1.892 mL 3.7839 mL 7.5679 mL 9.4598 mL
    10 mM 0.1892 mL 0.946 mL 1.892 mL 3.7839 mL 4.7299 mL
    50 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.7568 mL 0.946 mL
    100 mM 0.0189 mL 0.0946 mL 0.1892 mL 0.3784 mL 0.473 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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