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    Natural Products
    Cuniloside B
    Cuniloside B
    Information
    CAS No. 1187303-40-7 Price
    Catalog No.CFN99285Purity>=98%
    Molecular Weight512.6 Type of CompoundMonoterpenoids
    FormulaC26H40O10Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Cuniloside B

    Cuniloside B
    Product Name Cuniloside B
    CAS No.: 1187303-40-7
    Catalog No.: CFN99285
    Molecular Formula: C26H40O10
    Molecular Weight: 512.6 g/mol
    Purity: >=98%
    Type of Compound: Monoterpenoids
    Physical Desc.: Powder
    Targets: Antifection
    Source: The herbs of Eucalyptus microcory
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-leishmanial Compound Library
  • Monoterpenoids Compound Library
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  • Biological Activity
    Description: Cuniloside B shows anti-leishmanial activity.
    Targets: Antifection
    In vitro:
    Pharm Biol. 2012 Jul;50(7):823-7.
    Terpenoidal constituents of Eucalyptus loxophleba ssp. lissophloia.[Pubmed: 22468852]
    Eucalyptus has been a source of a number of biologically active compounds. The anti-leishmanial activity of terpenoids from Eucalyptus loxophleba (Benth.) ssp. lissophloia (Myrtaceae) has not yet been investigated. Isolation of the terpenoidal constituents for evaluation of in vitro anti-leishmanial activity against the Leishmania donovani (Dd8 strain) promastigotes.
    METHODS AND RESULTS:
    The chloroform-methanol (8:2) extract of dried leaves of Eucalyptus loxophleba was used to isolate terpenoidal constituents employing solvent partitioning, column chromatography and preparative high performance liquid chromatography and characterized from spectral data. The anti-leishmanial activity of the isolated compounds was tested in vitro using an Alamar blue assay against a culture of L. donovani (Dd8 strain) promastigotes. Two new naturally occurring triterpenes, named loxanic acid and 3-acetyl loxanic acid together with four known ursane triterpenoids and one bis-monoterpene glycoside, Cuniloside B isolated from the leaves showed anti-leishmanial activity (IC(50) 133 to 235 μM) against the promastigotes of the tested strain.
    CONCLUSIONS:
    The terpenes isolated from the leaves of E. loxophleba showed moderate anti-leishmanial activity.
    Cuniloside B Description
    Source: The herbs of Eucalyptus microcory
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9508 mL 9.7542 mL 19.5084 mL 39.0168 mL 48.771 mL
    5 mM 0.3902 mL 1.9508 mL 3.9017 mL 7.8034 mL 9.7542 mL
    10 mM 0.1951 mL 0.9754 mL 1.9508 mL 3.9017 mL 4.8771 mL
    50 mM 0.039 mL 0.1951 mL 0.3902 mL 0.7803 mL 0.9754 mL
    100 mM 0.0195 mL 0.0975 mL 0.1951 mL 0.3902 mL 0.4877 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Carbohydr Res. 2010 Sep 23;345(14):2079-84.
    Synthesis of the monoterpenoid esters cypellocarpin C and cuniloside B and evidence for their widespread occurrence in Eucalyptus.[Pubmed: 20708173]

    METHODS AND RESULTS:
    Short syntheses of Cuniloside B and cypellocarpin C, (+)-(R)-oleuropeic acid-containing carbohydrates, are reported. Also disclosed are syntheses of the noreugenin glycosides, undulatoside A and corymbosins K(1) and K(2). Leaf extracts of 28 diverse eucalypts revealed Cuniloside B to be present in all, and cypellocarpin C to be present in most, of the species examined.
    CONCLUSIONS:
    The widespread occurrence of these carbohydrate monoterpenoid esters supports their roles in essential oil biosynthesis or mobilization from sites of synthesis to secretory cavity lumena.
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