Science | Nature | Cell | View More
Natural Products
Curcumadione
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Curcumadione
Price:
CAS No.: 116425-36-6
Catalog No.: CFN92617
Molecular Formula: C15H22O2
Molecular Weight: 234.3 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Cryst.
Source: The rhizomes of Curcuma wenyujin
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Universidade do Porto (Portugal)
  • Medical University of Gdansk (Poland)
  • Northeast Normal University Cha... (China)
  • University of Virginia (USA)
  • Lund University (Sweden)
  • Fraunhofer-Institut für Moleku... (Germany)
  • Seoul National University (Korea)
  • University of Leipzig (Germany)
  • University of Hertfordshire (United Kingdom)
  • University of Pretoria (South Africa)
  • University of Fribourg (Switzerland)
  • More...
Package
Featured Products
Alisol A 24-acetate

Catalog No: CFN90198
CAS No: 18674-16-3
Price: $118/20mg
Praeruptorin A

Catalog No: CFN98139
CAS No: 73069-25-7
Price: $60/20mg
Ferulic acid

Catalog No: CFN99158
CAS No: 1135-24-6
Price: $40/20mg
Corynantheine

Catalog No: CFN92843
CAS No: 18904-54-6
Price: $ / mg
Quercetin-7-O-beta-D-glucopyranoside

Catalog No: CFN99771
CAS No: 491-50-9
Price: $318/10mg
Senecionine

Catalog No: CFN00417
CAS No: 130-01-8
Price: $ /
Butein

Catalog No: CFN98776
CAS No: 487-52-5
Price: $100/20mg
Rebaudioside B

Catalog No: CFN90470
CAS No: 58543-17-2
Price: $138/20mg
(-)-Asarinin

Catalog No: CFN90144
CAS No: 133-04-0
Price: $128/20mg
trans-3-Oxo-alpha-ionol

Catalog No: CFN92428
CAS No: 896107-70-3
Price: $ / mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Curcumadione shows certain acetylcholinesterase inhibitory activity.
Targets: AChR
In vitro:
Journal of Shandong University, 2013,48(7):20-3.
Chemical constituents of Curcuma xanthorrhiza Roxb. and their acetylcholinesterase inhibitory activity[Reference: WebLink]

METHODS AND RESULTS:
Chemical constituents from Curcuma xanthorrhiza Roxb. (Zingiberaceae) rhizome were isolated and purified by column chromatography (silica gel, RP silica gel MPLC, HPLC) and their structures were elucidated on the basis of spectral analyses. Six compounds were identified by MS and NMR spectroscopy as zederone(I), beta-sitosterol(II), Guai-1(10),3,5,7(11),8-pentaen-2-on-11,8-olide(III), Curcumadione(IV), Curcumenone (V), Cuparenol (VI). Compound III and VI were isolated for the first time from the plants of Zingiberaceae, and compound IV and V were isolated from Curcuma xanthorrhiza Roxb. for the first time. Meanwhile, the acetylcholinesterase inhibitory activity of the isolated compounds was evaluated.
CONCLUSIONS:
Compounds IV and VI showed certain inhibitory activity, the minimum inhibitory quantity of IV on TLC bioautography test was 95ug.
Curcumadione Description
Source: The rhizomes of Curcuma wenyujin
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Oblongaroside B

Catalog No: CFN95543
CAS No: 1000889-11-1
Price: $318/10mg
3-Oxo-alpha-ilexanolic acid

Catalog No: CFN95496
CAS No: N/A
Price: $413/5mg
2-Methoxyfuranoguaia-9-ene-8-one

Catalog No: CFN95220
CAS No: 88010-62-2
Price: $318/10mg
4-O-Caffeoyl-3-O-syringoylquinic a...

Catalog No: CFN95430
CAS No: 1207645-17-7
Price: $413/5mg
3-O-methylellagic acid 4'-O-alpha-...

Catalog No: CFN95228
CAS No: 51768-39-9
Price: $413/5mg
Bidenoside C

Catalog No: CFN95266
CAS No: 700877-55-0
Price: $318/5mg
Mahuannin E

Catalog No: CFN95585
CAS No: 1173887-70-1
Price: $318/5mg
Odontoside

Catalog No: CFN95530
CAS No: 20300-50-9
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.268 mL 21.3402 mL 42.6803 mL 85.3606 mL 106.7008 mL
5 mM 0.8536 mL 4.268 mL 8.5361 mL 17.0721 mL 21.3402 mL
10 mM 0.4268 mL 2.134 mL 4.268 mL 8.5361 mL 10.6701 mL
50 mM 0.0854 mL 0.4268 mL 0.8536 mL 1.7072 mL 2.134 mL
100 mM 0.0427 mL 0.2134 mL 0.4268 mL 0.8536 mL 1.067 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Med. 2009 Jan;63(1):102-4.
Sesquiterpenes from Curcuma comosa.[Pubmed: 18663560]

METHODS AND RESULTS:
From the dried rhizomes of Curcuma comosa cultivating in Thailand, 26 known sesquiterpenes were isolated: zederone, zederone epoxide, furanodienone, isofuranodienone, 1(10)Z,4Z-furanodiene-6-one, glechomanolide, dehydrocurdione, neocurdione, curdione, 7 alpha-hydroxyneocurdione, 7 beta-hydroxycurdione, germacrone-1(10),4-diepoxide, germacrone, 13-hydroxygermacrone, curzerenone, curcolonol, alismol, alismoxide, zedoarondiol, isozedoarondiol, procurcumenol, isoprocurcumenol, aerugidiol, zedoalactone B, curcumenone, and Curcumadione. Their structures were elucidated on the basis of physicochemical evidence.
CONCLUSIONS:
Among them, glechomanolide, curzerenone, curcolonol, alismol, alismoxide, and zedoarondiol showed no significant optical activities, so they may be artifact products during the isolation or drying process.
Zhongguo Zhong Yao Za Zhi. 2008 Apr;33(7):785-8.
Sesquiterpenes from stems and leaves of Curcuma wenyujin.[Pubmed: 18589781]
To study the chemical constituents of the stem and leaves from Curcuma wenyujin.
METHODS AND RESULTS:
The compounds were isolated by silica gel column chromatography in associating with Sephadex LH -20 chromatography. While their structures were identified on the basis of spectroscopic date. Nine sesquiterpenes were isolated and identified. Their structures were identified as curdione (1), neocurdione (2), trans, trans-germacrone (3), cis, trans-germacrone (4), curcumenone (5), Curcumadione (6), isoprocurcumenol (7), glechomanolide (8) and (1R, 10R)-( -)-1, 10-dihydrocurdione (9).
CONCLUSIONS:
All of these compounds were isolated from the stems and leaves of this plant for the first time.
Alisol A 24-acetate

Catalog No: CFN90198
CAS No: 18674-16-3
Price: $118/20mg
Praeruptorin A

Catalog No: CFN98139
CAS No: 73069-25-7
Price: $60/20mg
Ferulic acid

Catalog No: CFN99158
CAS No: 1135-24-6
Price: $40/20mg
Corynantheine

Catalog No: CFN92843
CAS No: 18904-54-6
Price: $ / mg
Quercetin-7-O-beta-D-glucopyranoside

Catalog No: CFN99771
CAS No: 491-50-9
Price: $318/10mg
Senecionine

Catalog No: CFN00417
CAS No: 130-01-8
Price: $ /
Butein

Catalog No: CFN98776
CAS No: 487-52-5
Price: $100/20mg
Rebaudioside B

Catalog No: CFN90470
CAS No: 58543-17-2
Price: $138/20mg
(-)-Asarinin

Catalog No: CFN90144
CAS No: 133-04-0
Price: $128/20mg
trans-3-Oxo-alpha-ionol

Catalog No: CFN92428
CAS No: 896107-70-3
Price: $ / mg
Tags: buy Curcumadione | Curcumadione supplier | purchase Curcumadione | Curcumadione cost | Curcumadione manufacturer | order Curcumadione | Curcumadione distributor