ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
How to Order
Orders via your E-mail:
1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: firstname.lastname@example.org
Order & Inquiry & Tech Support
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $9.3 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Molecules.2015, 20(11):20014-30Oncotarget.2015, 6(31):30831-49Int J Mol Med.2016, 37(2):501-8J Exp Bot.2016, 67(12):3777-88Free Radic Biol Med.2016, 97:307-319J Biochem Mol Toxicol.2017, 31(9)RSC Advances2017, 86Plant J.2017, 90(3):535-546
Food Quality and Safety2018, 2:213-219Life Sci.2018, 209:498-506Pharmacognosy Journal...2019...Mol Microbiol.2019, 112(1):317-332J of Physics Conference Series...2019...J Enzyme Inhib Med Chem....2019...Int J Oncol.2019, 55(1):320-330Phytomedicine.2019, 58:152893
Sci Rep.2019, 9(1):6429TCI CO.2019, US20190151281A1J Cell Physiol.2020, 10.1002Inflammation.2020, 43(5):1716-1728.J Ginseng Res.2020, 44(4):611-618.J Formos Med Assoc....2020...Molecules.2021, 26(2):E255.
Our products had been exported to the following research institutions and universities, And still growing.
Sanford Burnham Prebys Medical ... (USA)Max Rubner-Institut (MRI) (Germany)Fraunhofer-Institut für Moleku... (Germany)Universiti Malaysia Pahang (Malaysia)
Cornell University (USA)Pennsylvania State University (USA)University of Hull (United Kingdom)University of Illinois (USA)
University of Lodz (Poland)National Chung Hsing University (Taiwan)Kazusa DNA Research Institute (Japan)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
PLoS One.2020, 15(2):e0220084.Curr Top Med Chem.2020, 20(21):1898-1909.Life Sci.2018, 209:498-506Tumour Biol.2015, 36(12):9385-93Exp Neurobiol.2018, 27(3):200-209Front Pharmacol.2019, 10:1226Korean J of Medicinal Crop Science2018, 220-226J Ethnopharmacol.2017, 209:305-316Food Funct.2020, 11(2):1322-1333.Nat Prod Sci.2014, 20(3):182-190
Related Screening Libraries
||Ferulic acid is an antioxidant found naturally in plant cell walls , shows antioxidant activity in parallel with their radical scavenging activity, it has been approved in certain countries as food additive to prevent lipid peroxidation. Ferulic acid has been reported to have many physiological functions, including antioxidant, antimicrobial, anti-inflammatory, anti-thrombosis, anti- diabetic, and anti-cancer activities; it also protects against coronary disease, lowers cholesterol and increases sperm viability. |
||ROS | SOD | GPx | CAT | Antifection|
|J. Sci. Food Agr., 2004, 84(11):1261-9. |
|Ferulic acid: pharmaceutical functions, preparation and applications in foods.[Reference: WebLink]|
Ferulic acid (4‐hydroxy‐3‐methoxycinnamic acid), an effective component of Chinese medicine herbs such as Angelica sinensis, Cimicifuga heracleifolia and Lignsticum chuangxiong, is a ubiquitous phenolic acid in the plant kingdom. It is mainly conjugated with mono‐ and oligosaccharides, polyamines, lipids and polysaccharides and seldom occurs in a free state in plants. |
METHODS AND RESULTS:
Ferulic acid is a phenolic acid of low toxicity; it can be absorbed and easily metabolized in the human body. Ferulic acid has been reported to have many physiological functions, including antioxidant, antimicrobial, anti‐inflammatory, anti‐thrombosis, and anti‐cancer activities. It also protects against coronary disease, lowers cholesterol and increases sperm viability. Because of these properties and its low toxicity, Ferulic acid is now widely used in the food and cosmetic industries. It is used as the raw material for the production of vanillin and preservatives, as a cross‐linking agent for the preparation of food gels and edible films, and as an ingredient in sports foods and skin protection agents. Ferulic acid can be prepared by chemical synthesis and through biological transformation.
As polysaccharide ferulate is a natural and abundant source of Ferulic acid, preparation of Ferulic acid from plant cell wall materials will be a prospective pathway.
|2015 Oct 12;16(10):24011-31. |
|Ferulic Acid Exerts Anti-Angiogenic and Anti-Tumor Activity by Targeting Fibroblast Growth Factor Receptor 1-Mediated Angiogenesis[Pubmed: 26473837]|
|Most anti-angiogenic therapies currently being evaluated target the vascular endothelial growth factor (VEGF) pathway; however, the tumor vasculature can acquire resistance to VEGF-targeted therapy by shifting to other angiogenesis mechanisms. Therefore, other therapeutic agents that block non-VEGF angiogenic pathways need to be evaluated. Here, we identified Ferulic acid as a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor and a novel agent with potential anti-angiogenic and anti-cancer activities. Ferulic acid demonstrated inhibition of endothelial cell proliferation, migration and tube formation in response to basic fibroblast growth factor 1 (FGF1). In ex vivo and in vivo angiogenesis assays, Ferulic acid suppressed FGF1-induced microvessel sprouting of rat aortic rings and angiogenesis. To understand the underlying molecular basis, we examined the effects of Ferulic acid on different molecular components and found that Ferulic acid suppressed FGF1-triggered activation of FGFR1 and phosphatidyl inositol 3-kinase (PI3K)-protein kinase B (Akt) signaling. Moreover, Ferulic acid directly inhibited proliferation and blocked the PI3K-Akt pathway in melanoma cell. In vivo, using a melanoma xenograft model, Ferulic acid showed growth-inhibitory activity associated with inhibition of angiogenesis. Taken together, our results indicate that Ferulic acid targets the FGFR1-mediated PI3K-Akt signaling pathway, leading to the suppression of melanoma growth and angiogenesis.
Keywords: Akt; FGFR1; angiogenesis; Ferulic acid; melanoma.|
|Phytother Res. 2004 Apr;18(4):310-4. |
|Ferulic acid alleviates lipid peroxidation in diabetic rats.[Pubmed: 15162367 ]|
|Diabetes mellitus is a metabolic disorder associated with increased formation of free radicals. The objective of our study was to determine whether Ferulic acid (FA), a phenolic acid, has any role to play in diabetes induced free radical formation. |
METHODS AND RESULTS:
Diabetes was induced with streptozotocin. The levels of blood glucose, thiobarbituric acid reactive substances (TBARS), hydroperoxides and free fatty acids (FFA) increased in the liver of diabetic animals. The activities of glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) decreased in the liver. Histopathology of pancreas also shows shrunken islets. Supplementation of FA to the diabetic rats resulted in a decrease in the levels of glucose, TBARS, hydroperoxides, FFA and an increase in reduced glutathione (GSH). FA also resulted in increased activities of SOD, CAT, GPx and expansion of pancreatic islets. The effect was much pronounced with lower dose treatment.
Thus our study shows that administration of Ferulic acid helps in enhancing the antioxidant capacity of these diabetic animals by neutralizing the free radicals formed thereby reducing the intensity of diabetes.
Ferulic acid Description
||The rhizomes of Ferula sinkiangensis K.M.Shen.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Mater Sci Eng C Mater Biol Appl. 2015 Apr;49:691-9. |
|A potent inhibition of oxidative stress induced gene expression in neural cells by sustained ferulic acid release from chitosan based hydrogel.[Pubmed: 25686998]|
|Ferulic acid (4‐hydroxy‐3‐methoxycinnamic acid), an effective component of Chinese medicine herbs such as Angelica sinensis, Cimicifuga heracleifolia and Lignsticum chuangxiong, is a ubiquitous phenolic acid in the plant kingdom. |
METHODS AND RESULTS:
It is mainly conjugated with mono‐ and oligosaccharides, polyamines, lipids and polysaccharides and seldom occurs in a free state in plants. Ferulic acid is a phenolic acid of low toxicity; it can be absorbed and easily metabolized in the human body. Ferulic acid has been reported to have many physiological functions, including antioxidant, antimicrobial, anti‐inflammatory, anti‐thrombosis, and anti‐cancer activities. It also protects against coronary disease, lowers cholesterol and increases sperm viability. Because of these properties and its low toxicity, Ferulic acid is now widely used in the food and cosmetic industries.
It is used as the raw material for the production of vanillin and preservatives, as a cross‐linking agent for the preparation of food gels and edible films, and as an ingredient in sports foods and skin protection agents.
Ferulic acid can be prepared by chemical synthesis and through biological transformation. As polysaccharide ferulate is a natural and abundant source of Ferulic acid, preparation of Ferulic acid from plant cell wall materials will be a prospective pathway.
|Crit Rev Biotechnol. 2004;24(2-3):59-83. |
|Ferulic acid: an antioxidant found naturally in plant cell walls and feruloyl esterases involved in its release and their applications.[Pubmed: 15493526 ]|
|Ferulic acid is the most abundant hydroxycinnamic acid in the plant world and maize bran with 3.1% (w/w) Ferulic acid is one of the most promising sources of this antioxidant. |
METHODS AND RESULTS:
The dehydrodimers of Ferulic acid are important structural components in the plant cell wall and serve to enhance its rigidity and strength. Feruloyl esterases are a subclass of the carboxylic acid esterases that hydrolyze the ester bond between hydroxycinnamic acids and sugars present in plant cell walls and they have been isolated from a wide range of microorganisms, when grown on complex substrates such as cereal brans, sugar beet pulp, pectin and xylan. These enzymes perform a function similar to alkali in the deesterification of plant cell wall and differ in their specificities towards the methyl esters of cinnamic acids and ferulolylated oligosaccharides. They act synergistically with xylanases and pectinases and facilitate the access of hydrolases to the backbone of cell wall polymers.
The applications of Ferulic acid and feruloyl esterase enzymes are many and varied. Ferulic acid obtained from agricultural byproducts is a potential precursor for the production of natural vanillin, due to the lower production cost.