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    Ferulic acid
    Information
    CAS No. 1135-24-6 Price $40 / 20mg
    Catalog No.CFN99158Purity>=98%
    Molecular Weight194.19Type of CompoundPhenylpropanoids
    FormulaC10H10O4Physical DescriptionPowder
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    Ferulic acid

    Ferulic acid
    Product Name Ferulic acid
    CAS No.: 1135-24-6
    Catalog No.: CFN99158
    Molecular Formula: C10H10O4
    Molecular Weight: 194.19 g/mol
    Purity: >=98%
    Type of Compound: Phenylpropanoids
    Physical Desc.: Powder
    Targets: ROS | SOD | GPx | CAT | Antifection
    Source: The rhizomes of Ferula sinkiangensis K.M.Shen.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $40 / 20mg
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  • PLoS One.2020, 15(2):e0220084.
  • Curr Top Med Chem.2020, 20(21):1898-1909.
  • Life Sci.2018, 209:498-506
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  • Exp Neurobiol.2018, 27(3):200-209
  • Front Pharmacol.2019, 10:1226
  • Korean J of Medicinal Crop Science2018, 220-226
  • J Ethnopharmacol.2017, 209:305-316
  • Food Funct.2020, 11(2):1322-1333.
  • Nat Prod Sci.2014, 20(3):182-190
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: Ferulic acid is an antioxidant found naturally in plant cell walls , shows antioxidant activity in parallel with their radical scavenging activity, it has been approved in certain countries as food additive to prevent lipid peroxidation. Ferulic acid has been reported to have many physiological functions, including antioxidant, antimicrobial, anti-inflammatory, anti-thrombosis, anti- diabetic, and anti-cancer activities; it also protects against coronary disease, lowers cholesterol and increases sperm viability.
    Targets: ROS | SOD | GPx | CAT | Antifection
    In vitro:
    J. Sci. Food Agr., 2004, 84(11):1261-9.
    Ferulic acid: pharmaceutical functions, preparation and applications in foods.[Reference: WebLink]
    Ferulic acid (4‐hydroxy‐3‐methoxycinnamic acid), an effective component of Chinese medicine herbs such as Angelica sinensis, Cimicifuga heracleifolia and Lignsticum chuangxiong, is a ubiquitous phenolic acid in the plant kingdom. It is mainly conjugated with mono‐ and oligosaccharides, polyamines, lipids and polysaccharides and seldom occurs in a free state in plants.
    METHODS AND RESULTS:
    Ferulic acid is a phenolic acid of low toxicity; it can be absorbed and easily metabolized in the human body. Ferulic acid has been reported to have many physiological functions, including antioxidant, antimicrobial, anti‐inflammatory, anti‐thrombosis, and anti‐cancer activities. It also protects against coronary disease, lowers cholesterol and increases sperm viability. Because of these properties and its low toxicity, Ferulic acid is now widely used in the food and cosmetic industries. It is used as the raw material for the production of vanillin and preservatives, as a cross‐linking agent for the preparation of food gels and edible films, and as an ingredient in sports foods and skin protection agents. Ferulic acid can be prepared by chemical synthesis and through biological transformation.
    CONCLUSIONS:
    As polysaccharide ferulate is a natural and abundant source of Ferulic acid, preparation of Ferulic acid from plant cell wall materials will be a prospective pathway.
    2015 Oct 12;16(10):24011-31.
    Ferulic Acid Exerts Anti-Angiogenic and Anti-Tumor Activity by Targeting Fibroblast Growth Factor Receptor 1-Mediated Angiogenesis[Pubmed: 26473837]
    Most anti-angiogenic therapies currently being evaluated target the vascular endothelial growth factor (VEGF) pathway; however, the tumor vasculature can acquire resistance to VEGF-targeted therapy by shifting to other angiogenesis mechanisms. Therefore, other therapeutic agents that block non-VEGF angiogenic pathways need to be evaluated. Here, we identified Ferulic acid as a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor and a novel agent with potential anti-angiogenic and anti-cancer activities. Ferulic acid demonstrated inhibition of endothelial cell proliferation, migration and tube formation in response to basic fibroblast growth factor 1 (FGF1). In ex vivo and in vivo angiogenesis assays, Ferulic acid suppressed FGF1-induced microvessel sprouting of rat aortic rings and angiogenesis. To understand the underlying molecular basis, we examined the effects of Ferulic acid on different molecular components and found that Ferulic acid suppressed FGF1-triggered activation of FGFR1 and phosphatidyl inositol 3-kinase (PI3K)-protein kinase B (Akt) signaling. Moreover, Ferulic acid directly inhibited proliferation and blocked the PI3K-Akt pathway in melanoma cell. In vivo, using a melanoma xenograft model, Ferulic acid showed growth-inhibitory activity associated with inhibition of angiogenesis. Taken together, our results indicate that Ferulic acid targets the FGFR1-mediated PI3K-Akt signaling pathway, leading to the suppression of melanoma growth and angiogenesis. Keywords: Akt; FGFR1; angiogenesis; Ferulic acid; melanoma.
    In vivo:
    Phytother Res. 2004 Apr;18(4):310-4.
    Ferulic acid alleviates lipid peroxidation in diabetic rats.[Pubmed: 15162367 ]
    Diabetes mellitus is a metabolic disorder associated with increased formation of free radicals. The objective of our study was to determine whether Ferulic acid (FA), a phenolic acid, has any role to play in diabetes induced free radical formation.
    METHODS AND RESULTS:
    Diabetes was induced with streptozotocin. The levels of blood glucose, thiobarbituric acid reactive substances (TBARS), hydroperoxides and free fatty acids (FFA) increased in the liver of diabetic animals. The activities of glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) decreased in the liver. Histopathology of pancreas also shows shrunken islets. Supplementation of FA to the diabetic rats resulted in a decrease in the levels of glucose, TBARS, hydroperoxides, FFA and an increase in reduced glutathione (GSH). FA also resulted in increased activities of SOD, CAT, GPx and expansion of pancreatic islets. The effect was much pronounced with lower dose treatment.
    CONCLUSIONS:
    Thus our study shows that administration of Ferulic acid helps in enhancing the antioxidant capacity of these diabetic animals by neutralizing the free radicals formed thereby reducing the intensity of diabetes.
    Ferulic acid Description
    Source: The rhizomes of Ferula sinkiangensis K.M.Shen.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.1496 mL 25.748 mL 51.496 mL 102.9919 mL 128.7399 mL
    5 mM 1.0299 mL 5.1496 mL 10.2992 mL 20.5984 mL 25.748 mL
    10 mM 0.515 mL 2.5748 mL 5.1496 mL 10.2992 mL 12.874 mL
    50 mM 0.103 mL 0.515 mL 1.0299 mL 2.0598 mL 2.5748 mL
    100 mM 0.0515 mL 0.2575 mL 0.515 mL 1.0299 mL 1.2874 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Mater Sci Eng C Mater Biol Appl. 2015 Apr;49:691-9.
    A potent inhibition of oxidative stress induced gene expression in neural cells by sustained ferulic acid release from chitosan based hydrogel.[Pubmed: 25686998]
    Ferulic acid (4‐hydroxy‐3‐methoxycinnamic acid), an effective component of Chinese medicine herbs such as Angelica sinensis, Cimicifuga heracleifolia and Lignsticum chuangxiong, is a ubiquitous phenolic acid in the plant kingdom.
    METHODS AND RESULTS:
    It is mainly conjugated with mono‐ and oligosaccharides, polyamines, lipids and polysaccharides and seldom occurs in a free state in plants. Ferulic acid is a phenolic acid of low toxicity; it can be absorbed and easily metabolized in the human body. Ferulic acid has been reported to have many physiological functions, including antioxidant, antimicrobial, anti‐inflammatory, anti‐thrombosis, and anti‐cancer activities. It also protects against coronary disease, lowers cholesterol and increases sperm viability. Because of these properties and its low toxicity, Ferulic acid is now widely used in the food and cosmetic industries.
    CONCLUSIONS:
    It is used as the raw material for the production of vanillin and preservatives, as a cross‐linking agent for the preparation of food gels and edible films, and as an ingredient in sports foods and skin protection agents. Ferulic acid can be prepared by chemical synthesis and through biological transformation. As polysaccharide ferulate is a natural and abundant source of Ferulic acid, preparation of Ferulic acid from plant cell wall materials will be a prospective pathway.
    Structure Identification:
    Crit Rev Biotechnol. 2004;24(2-3):59-83.
    Ferulic acid: an antioxidant found naturally in plant cell walls and feruloyl esterases involved in its release and their applications.[Pubmed: 15493526 ]
    Ferulic acid is the most abundant hydroxycinnamic acid in the plant world and maize bran with 3.1% (w/w) Ferulic acid is one of the most promising sources of this antioxidant.
    METHODS AND RESULTS:
    The dehydrodimers of Ferulic acid are important structural components in the plant cell wall and serve to enhance its rigidity and strength. Feruloyl esterases are a subclass of the carboxylic acid esterases that hydrolyze the ester bond between hydroxycinnamic acids and sugars present in plant cell walls and they have been isolated from a wide range of microorganisms, when grown on complex substrates such as cereal brans, sugar beet pulp, pectin and xylan. These enzymes perform a function similar to alkali in the deesterification of plant cell wall and differ in their specificities towards the methyl esters of cinnamic acids and ferulolylated oligosaccharides. They act synergistically with xylanases and pectinases and facilitate the access of hydrolases to the backbone of cell wall polymers.
    CONCLUSIONS:
    The applications of Ferulic acid and feruloyl esterase enzymes are many and varied. Ferulic acid obtained from agricultural byproducts is a potential precursor for the production of natural vanillin, due to the lower production cost.
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