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Cyclo(Pro-Leu)
Cyclo(Pro-Leu)
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cyclo(Pro-Leu)
Price: $238 / 10mg
CAS No.: 5654-86-4
Catalog No.: CFN90281
Molecular Formula: C11H18N2O2
Molecular Weight: 210.27 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: From Pantoea agglomerans.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $99.2 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cyclo(Pro-Leu) has brine shrimp lethality.
Cyclo(Pro-Leu) Description
Source: From Pantoea agglomerans.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.7558 mL 23.779 mL 47.5579 mL 95.1158 mL 118.8948 mL
5 mM 0.9512 mL 4.7558 mL 9.5116 mL 19.0232 mL 23.779 mL
10 mM 0.4756 mL 2.3779 mL 4.7558 mL 9.5116 mL 11.8895 mL
50 mM 0.0951 mL 0.4756 mL 0.9512 mL 1.9023 mL 2.3779 mL
100 mM 0.0476 mL 0.2378 mL 0.4756 mL 0.9512 mL 1.1889 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Nat Prod Res. 2014;28(7):473-6.
A new diketopiperazine from the gorgonian coral Menella kanisa.[Pubmed: 24479814]
Chemical investigation on the gorgonian Menella kanisa collected from Beibu Gulf led to the isolation of a new diketopiperazine, named menazepine A (1), as well as three known diketopiperazines, namely cyclo(4-hydroxyprolylleucyl) (2), Cyclo(Pro-Leu) (3) and cyclo(4-hydroxyprolylphenylalanyl) (4).
METHODS AND RESULTS:
The structure of the new diketopiperazine was elucidated on the basis of extensive spectroscopic analysis and by comparing the data with those of related metabolites. Compounds 1-4 were also evaluated for brine shrimp lethality.
CFN96160Cyclo(Gly-L-Pro)3705-27-9154.2C7H10N2O2
CFN90282Cyclo(Pro-Ala)65556-33-4168.20C8H12N2O2
CFN96111Cyclo(L-Ala-L-Pro)36357-32-1168.2C8H12N2O2
CFN91572Cyclo(Ser-Pro)1355217-25-2184.2C8H12N2O3
CFN90275Cyclo(Pro-Val)5654-87-5196.25C10H16N2O2
CFN96114Cyclo(D-Val-L-Pro)27483-18-7196.3C10H16N2O2
CFN91062Cyclo(Hyp-Val)1425501-89-8212.2C10H16N2O3
CFN90281Cyclo(Pro-Leu)5654-86-4210.27C11H18N2O2
CFN96128Cyclo(D-Leu-L-Pro)36238-67-2210.3C11H18N2O2
CFN90285Cyclo(Hpro-Leu)1016899-93-6226.27C11H18N2O3
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