ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Acta Biochim Pol.2015, 62(2):253-8Nutrients.2017, 10(1)Sci Rep.2017, 7:467-479Life Sci.2018, 209:498-506Bioorg Med Chem.2018, 26(14):4201-4208J of Physics Conference Series...2019...Int J Mol Sci.2019, 20(14):E3538Molecules.2019, 24(21):E3834
J Ethnopharmacol.2019, 241:112025Food Chem.2019, 275:746-753Food Chem.2019, 290:286-294Int J Food Sci Nutr.2019, 70(7):825-833TCI CO.2019, US20190151281A1Drug Des Devel Ther.2020, 14:61-71J Insect Sci.2020, 20(5):18. Int J Mol Sci.2020, 21(24):9369.
Int J Mol Sci.2020, 21(9):3392. Molecules.2020, 25(20):4851.Food Chem.2020, 332:127412J Sep Sci.2020, 43(22):4148-4161.Naunyn Schmiedebergs Arch Pharmac...2021...Evid Based Complement Alternat Me...2021...Inflammation.2021, doi: 10.1007
More...
Our products had been exported to the following research institutions and universities, And still growing.
Kyung Hee University (Korea)Universiti Malaysia Pahang (Malaysia)Monash University Malaysia (Malaysia)Universidade Federal de Pernamb... (Brazil)
Universite Libre de Bruxelles (Belgium)University of Parma (Italy)Imperial College London (United Kingdom)Mahidol University (Thailand)
Siksha O Anusandhan University (India)Utah State University (USA)Medizinische Universit?t Wien (Austria)
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Cycloartane-3,24,25-triol
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Molecules.2020, 25(20):4851.Molecules.2020 ,25(16):3697.South African J of Botany2020, 135:50-57Korean J of Crop Science2019, 452-458Food Quality and Safety2018, 2:213-219Drug Invention Today2019, 12(6):1303-1306J.Acta Agriculturae Scandinavica2017, 571-575Exp Neurobiol.2018, 27(3):200-209Postharvest Biol Tec2019, 149:18-26Korean Herb. Med. Inf.2020, 8(2):205-213
Related Screening Libraries
| Description: |
Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.
|
| Targets: |
ATPase |
| In vitro: |
| Cancer Cell Int. 2012 Nov 14;12(1):46. | | Cycloartane-3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro.[Pubmed: 23151005] | Given the high occurrence of prostate cancer worldwide and one of the major sources of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the possible anti-cancer activity of two natural cycloartanes; cycloartane-3,24,25-diol (extracted in our lab from Tillandsia recurvata) and Cycloartane-3,24,25-triol (purchased). The inhibition of MRCKα kinase has emerged as a potential solution to restoring the tight regulation of normal cellular growth, the loss of which leads to cancer cell formation.
METHODS AND RESULTS:
Kinase inhibition was investigated using competition binding (to the ATP sites) assays which have been previously established and authenticated and cell proliferation was measured using the WST-1 assay. Cycloartane-3,24,25-triol demonstrated strong selectivity towards the MRCKα kinase with a Kd50 of 0.26 μM from a total of 451 kinases investigated. Cycloartane-3,24,25-triol reduced the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.
CONCLUSIONS:
These results will prove useful in drug discovery as Cycloartane-3,24,25-triol has shown potential for development as an anti-cancer agent against prostate cancer. |
|
Cycloartane-3,24,25-triol Description
| Source: |
The barks of Aphanamixis polystachya |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.1706 mL |
10.853 mL |
21.7061 mL |
43.4122 mL |
54.2652 mL |
| 5 mM |
0.4341 mL |
2.1706 mL |
4.3412 mL |
8.6824 mL |
10.853 mL |
| 10 mM |
0.2171 mL |
1.0853 mL |
2.1706 mL |
4.3412 mL |
5.4265 mL |
| 50 mM |
0.0434 mL |
0.2171 mL |
0.4341 mL |
0.8682 mL |
1.0853 mL |
| 100 mM |
0.0217 mL |
0.1085 mL |
0.2171 mL |
0.4341 mL |
0.5427 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
