ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
How to Order
Orders via your E-mail:
1. Product number / Name / CAS No.
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J Pharm Biomed Anal.2018, 151:32-41Nutrients.2020, 12(3):595.Front Immunol.2018, 9:2091Nat Prod Sci.2014, 20(3):182-190Molecules.2021, 26(6):1738. Nutrients.2020, 12(5):1242.Toxicol Mech Methods.2021, 1-12.Molecules.2020, 25(15):3353.
Int J Anal Chem.2017, 2017:1254721J. Soc. Cosmet. Sci. Korea...2021...J Ethnopharmacol.2020, 269:113752. Front Pharmacol.2021, 12:690113.Toxins (Basel).2019, 11(10):E575Biochem Biophys Res Commun....2021...JPC-Journal of Planar Chromatogra...2017...Appl Microbiol Biotechnol....2016...
Anat Rec (Hoboken)....2021...J Food Sci Technol....2019...Faculty of Chem. & Nat. Resource ...2014...Comparative Clinical Pathology ...2021...Plant Foods Hum Nutr.2020, 10.1007Molecules.2020, 25(9):2111.Phytomedicine.2016, 23(4):331-9
Our products had been exported to the following research institutions and universities, And still growing.
Sri Ramachandra University (India)Institute of Bioorganic Chemist... (Poland)Cancer Research Initatives Foun... (Malaysia)University of Beira Interior (Portugal)
University of British Columbia (Canada)S.N.D.T. Women's University (India)National Chung Hsing University (Taiwan)Universiti Malaysia Pahang (Malaysia)
Periyar University (India)Calcutta University (India)Heinrich-Heine-University Düss... (Germany)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Chemistry of Natural Compounds2018, 54(3):572-576Oncol Rep.2021, 46(2):166.J Sep Sci.2018, 41(9):1938-1946Acta Biochim Pol.2015, 62(2):253-8Phytomedicine.2019, 67:153159Plant Sci.2020, 301:110656.Aquaculture2019, 510:392-399Asian J Beauty Cosmetol2016, 14(3):249-257Food Chem.2016, 191:81-90Nutr Res Pract2019, 13:e45
Related Screening Libraries
||Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.
|Cancer Cell Int. 2012 Nov 14;12(1):46. |
|Cycloartane-3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro.[Pubmed: 23151005]|
|Given the high occurrence of prostate cancer worldwide and one of the major sources of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the possible anti-cancer activity of two natural cycloartanes; cycloartane-3,24,25-diol (extracted in our lab from Tillandsia recurvata) and Cycloartane-3,24,25-triol (purchased). The inhibition of MRCKα kinase has emerged as a potential solution to restoring the tight regulation of normal cellular growth, the loss of which leads to cancer cell formation. |
METHODS AND RESULTS:
Kinase inhibition was investigated using competition binding (to the ATP sites) assays which have been previously established and authenticated and cell proliferation was measured using the WST-1 assay. Cycloartane-3,24,25-triol demonstrated strong selectivity towards the MRCKα kinase with a Kd50 of 0.26 μM from a total of 451 kinases investigated. Cycloartane-3,24,25-triol reduced the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.
These results will prove useful in drug discovery as Cycloartane-3,24,25-triol has shown potential for development as an anti-cancer agent against prostate cancer.
||The barks of Aphanamixis polystachya
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.