ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
3. Inhibitors
Quasipanaxatriol
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $413 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Evid Based Complement Alternat Me...2015...Molecules.2016, 21(6)Free Radic Biol Med.2016, 97:307-319Hum Exp Toxicol.2017, 36(11):1169-1176Universidade Estadual Paulista...2017...Front Pharmacol.2017, 8:673South African J of Plant&Soil...2018...RSC Adv.2018, 32621-32636
Phytomedicine.2018, 40:37-47Int J Mol Sci.2019, 20(21):E5488J of the Korean Society of Cosmet...2019...Exp Biol Med (Maywood)....2019...Molecules.2019, 25(1):E103Kor. J. Herbol.2019, 34(2):59-66Phytomedicine.2019, 62:152962J Mol Recognit.2020, 33(2):e2819
Front Microbiol.2020, 11:583594.LWT2020, 124:109163Evid Based Complement Alternat Me...2020...Int J Mol Sci.2020, 21(7):2530.J Med Food.2020, 23(6):633-640.J Appl Toxicol.2020, 40(7):965-978.J of Food Quality2020, 8851285.
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Our products had been exported to the following research institutions and universities, And still growing.
S.N.D.T. Women's University (India)Utrecht University (Netherlands)Heidelberg University (Germany)Michigan State University (USA)
University of Perugia (Italy)MTT Agrifood Research Finland (Finland)The Vancouver Prostate Centre (... (Canada)Copenhagen University (Denmark)
VIT University (India)Aveiro University (Portugal)National Cancer Center Research... (Japan)
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Quasipanaxatriol
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Oncotarget.2016, 8(51):88386-88400Toxicol In Vitro.2019, 59:161-178BMC Complement Altern Med.2019, 19(1):325J Ethnopharmacol.2018, 210:88-94Molecules.2018, 23(7):E1817Korean Journal of Pharmacognosy2019, 50(4):285-290Molecules.2020, 25(23):5636.Molecules.2017, 22(2)Appl Biochem Biotechnol.2020, 190(2):732-744PLoS One.2018, 13(11):e0208055
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Triterpenoids Compound Library |
| Description: |
Quasipanaxatriol can greatly enhance the cytotoxicity of the anti-cancer drugs in P388/ADM cells. |
| In vitro: |
| Planta Med 1995; 61(5): 409-413. | | Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistant P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids.[Reference: WebLink] |
METHODS AND RESULTS:
Examined in vitro were the effects of some triterpenoids from Panax (Araliaceae) and Glycyrrhiza (Leguminosae) spp. on the sensitivity to daunomycin (DAU) and vinblastine (VBL) of adriamycin (ADM)-resistant P388 leukemia cells (P388/ADM), which were resistant to multiple anticancer drugs.
Quasipanaxatriol, 20(S)-protopanaxatriol, ginsenoside Rh2, and compound K greatly enhanced the cytotoxicity of the anti-cancer drugs in P388/ADM cells. The extent of enhancement was different among the triterpene compounds; the 4- to 46-fold increase in DAU cytotoxicity was observed in P388/ADM cells in the presence of non-toxic or marginally toxic concentrations of individual compounds, while those for VBL were in the ratios of 2- to 37-fold. The maximum increase in cytotoxicity was observed with 50 µM Quasipanaxatriol; the resistance indices defined to be the ratios of the IC50 values for P388/ADM and P388 parental cells decreased from 79 to 1.7 and from 180 to 4.9 in the cases of DAU and VBL, respectively.
CONCLUSIONS:
The reversal of DAU resistance in P388/ADM by Quasipanaxatriol could be explained by the effective accumulation of the drugs mediated by the DAU-efflux blockage. |
|
Quasipanaxatriol Description
| Source: |
The roots of Panax ginseng C. A. Mey. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.1801 mL |
10.9004 mL |
21.8007 mL |
43.6015 mL |
54.5019 mL |
| 5 mM |
0.436 mL |
2.1801 mL |
4.3601 mL |
8.7203 mL |
10.9004 mL |
| 10 mM |
0.218 mL |
1.09 mL |
2.1801 mL |
4.3601 mL |
5.4502 mL |
| 50 mM |
0.0436 mL |
0.218 mL |
0.436 mL |
0.872 mL |
1.09 mL |
| 100 mM |
0.0218 mL |
0.109 mL |
0.218 mL |
0.436 mL |
0.545 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
