ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $413 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Int J Mol Sci.2021, 22(21):11447.Neuropharmacology2019, 151437Exp Biol Med (Maywood)....2019...Analytical Letters 2021, 54(4).Asian J Beauty Cosmetol...2019...Int J Mol Sci.2015, 16(8):18396-411Int J Mol Sci.2019, 20(8):E1855PLoS One.2017, 12(8):e0181191
Sci Rep.2018, 8(1):12970Molecules.2020, 25(23):5636.J Appl Biol Chem2021, 64(3):245-251.Earth Environ. Sci. 2021, 905:012080.Front Pharmacol.2021, 12:635510.Journal of Analytical Chemistry...2017...Neurotox Res.2020, 38(1):163-174.Appl Microbiol Biotechnol....2018...
J Pharm Anal.2016, 6(6):363-373J Cell Mol Med.2021, 25(5):2645-2654. New Zealand J. Forestry Sci.2014, 44:17Exp Ther Med.2019, 18(6):4388-4396RSC Adv.2018, 32621-32636Pest Manag Sci.2019, 75(9):2530-2541Antioxidants (Basel).2021, 10(9):1487.
Our products had been exported to the following research institutions and universities, And still growing.
Melbourne University (Australia)Siksha O Anusandhan University (India)University of Bonn (Germany)Seoul National University (Korea)
University of South Australia (Australia)University of Medicine and Phar... (Romania)Molecular Biology Institute of ... (Spain)Weizmann Institute of Science (Israel)
University of British Columbia (Canada)Sant Gadge Baba Amravati Univer... (India)Universidad de Buenos Aires (Argentina)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Int J Immunopathol Pharmacol.2019, 33:2058738419857537Inflammation.2020, 43(5):1716-1728.PLoS One.2017, 12(3):e0173585J Korean Society of Food Science & Nutrition2021, 50(9): 962-970PLoS One.2020, 15(2):e0220084.Anat Rec2018, 24264FASEB J.2019, 33(8):9685-9694Analytical methods2019, 11(6)Chemistry of Plant Materials.2016, 33-46Biotechnol Bioeng.2020, 117(7):2198-2208.
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Triterpenoids Compound Library
|| Quasipanaxatriol can greatly enhance the cytotoxicity of the anti-cancer drugs in P388/ADM cells. |
|Planta Med 1995; 61(5): 409-413. |
|Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistant P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids.[Reference: WebLink]|
METHODS AND RESULTS:
Examined in vitro were the effects of some triterpenoids from Panax (Araliaceae) and Glycyrrhiza (Leguminosae) spp. on the sensitivity to daunomycin (DAU) and vinblastine (VBL) of adriamycin (ADM)-resistant P388 leukemia cells (P388/ADM), which were resistant to multiple anticancer drugs.
Quasipanaxatriol, 20(S)-protopanaxatriol, ginsenoside Rh2, and compound K greatly enhanced the cytotoxicity of the anti-cancer drugs in P388/ADM cells. The extent of enhancement was different among the triterpene compounds; the 4- to 46-fold increase in DAU cytotoxicity was observed in P388/ADM cells in the presence of non-toxic or marginally toxic concentrations of individual compounds, while those for VBL were in the ratios of 2- to 37-fold. The maximum increase in cytotoxicity was observed with 50 µM Quasipanaxatriol; the resistance indices defined to be the ratios of the IC50 values for P388/ADM and P388 parental cells decreased from 79 to 1.7 and from 180 to 4.9 in the cases of DAU and VBL, respectively.
The reversal of DAU resistance in P388/ADM by Quasipanaxatriol could be explained by the effective accumulation of the drugs mediated by the DAU-efflux blockage.
||The roots of Panax ginseng C. A. Mey.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.