Cycloolivil | CAS:3064-05-9 | Manufacturer ChemFaces

Cycloolivil

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $185.3 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

(+)-Cycloolivil has antioxidant activity, it may prevent thrombotic complications associated to platelet hyperaggregability and be the base for the development of antiaggregant therapeutic strategies.

Targets:

Calcium Channel

In vitro:

Blood Cell. Mol. Dis., 2009, 42(3):279-85.

Olive tree wood phenolic compounds with human platelet antiaggregant properties.[Pubmed: 19195914]

Oleuropein and (+)-Cycloolivil are natural polyphenolic compounds with a significant radical scavenging activity present in olive tree. We have investigated the antiaggregant effects of oleuropein and (+)-Cycloolivil isolated from an ethyl acetate extract of olive tree wood.
METHODS AND RESULTS:
Oleuropein and (+)-Cycloolivil reduced the ability of thrombin to stimulate platelet aggregation. Both compounds reduced thrombin-evoked Ca(2+) release and entry to a similar extent to hydroxytyrosol. This effect was greater in platelets from patients with type 2 diabetes mellitus than in controls. Thrombin-, thapsigargin- and 2,5-di-(tert-butyl)-1,4-hydroquinone (TBHQ)-evoked protein tyrosine phosphorylation, which is involved in Ca(2+) signalling and platelet aggregation, is inhibited by oleuropein and (+)-Cycloolivil. oleuropein and (+)-Cycloolivil are natural oxygen radical scavengers that reduce thrombin-induced protein tyrosine phosphorylation, Ca(2+) signalling and platelet aggregation.
CONCLUSIONS:
These observations suggest that oleuropein and (+)-Cycloolivil may prevent thrombotic complications associated to platelet hyperaggregability and be the base for the development of antiaggregant therapeutic strategies.

Cycloolivil Description

Source:	The herbs of Maytenus hookeri Loes.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Cycloolivil
Price:	$268 / 5mg
CAS No.:	3064-05-9
Catalog No.:	CFN96185
Molecular Formula:	C₂₀H₂₄O₇
Molecular Weight:	376.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The herbs of Maytenus hookeri Loes.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Anti-platelet aggregation Compound Library Lignans Compound Library Calcium Channel Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6567 mL	13.2837 mL	26.5675 mL	53.135 mL	66.4187 mL
5 mM	0.5313 mL	2.6567 mL	5.3135 mL	10.627 mL	13.2837 mL
10 mM	0.2657 mL	1.3284 mL	2.6567 mL	5.3135 mL	6.6419 mL
50 mM	0.0531 mL	0.2657 mL	0.5313 mL	1.0627 mL	1.3284 mL
100 mM	0.0266 mL	0.1328 mL	0.2657 mL	0.5313 mL	0.6642 mL

CFN98276	9,9'-O-Isopropyllidene-isolariciresinol	252333-71-4	400.5	C₂₃H₂₈O₆
CFN96693	Schizandriside	71222-06-5	492.52	C₂₅H₃₂O₁₀
CFN89431	(-)-Isolariciresinol 9'-O-glucoside	143236-04-8	522.54	C₂₆H₃₄O₁₁
CFN96194	Vitexdoin A	1186021-77-1	342.4	C₁₉H₁₈O₆
CFN99605	7,8,9,9-Tetradehydroisolariciresinol	145918-59-8	356.4	C₂₀H₂₀O₆
CFN96448	Vitedoin A	819861-40-0	356.37	C₂₀H₂₀O₆
CFN95403	(-)-5'-Methoxyisolariciresinol 3alpha-O-beta-glucopyranoside	143236-03-7	552.6	C₂₇H₃₆O₁₂
CFN99488	(+)-Lyoniresinol	14464-90-5	420.5	C₂₂H₂₈O₈
CFN98451	Lyoniside	34425-25-7	552.6	C₂₇H₃₆O₁₂
CFN97964	(+)-Lyoniresinol 9'-O-glucoside	87585-32-8	582.6	C₂₈H₃₈O₁₃