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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $121.7 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
BMC Complement Altern Med.2014, 14:352Fitoterapia.2015, 100:179-86Evid Based Complement Alternat Me...2015...FEBS Lett.2015, 589(1):182-7J Ethnopharmacol.2016, 194:219-227Anal Bioanal Chem. 2016, 408(15)J Exp Bot.2016, 67(12):3777-88Research on Crops.2017, 18(3):569
Universite de Bordeaux...2017...Phytochemistry Letters2017, 449-455The Japan Society for Analy. Chem...2017...Nutrients.2018, 10(7)Korean J Dent Mater.2018, 45(2):139-146J Herbmed Pharmacol.2018, 7(4):280-286Asian Pac J Cancer Prev....2019...J Med Food.2019, 22(10):1067-1077
Molecules.2019, 24(22):E4022Molecules.2019, 24(6):E1155Cell Mol Biol(Noisy-le-grand)...2019...Planta Med.2019, 85(3):217-224Molecules.2020, 25(3):734Pharmaceutics.2020, 12(9):845.J Cell Mol Med....2020...
Our products had been exported to the following research institutions and universities, And still growing.
Cornell University (USA)Uniwersytet Medyczny w ?odzi (Poland)Universitas islam negeri Jakarta (Indonesia)Universidad Industrial de Santa... (Colombia)
Mahidol University (Thailand)Universidade Católica Portuguesa (Portugal)National Hellenic Research Foun... (Greece)S.N.D.T. Women's University (India)
Colorado State University (USA)Universidad de Antioquia (Colombia)Molecular Biology Institute of ... (Spain)
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Biochem Biophys Res Commun.2018, 505(4):1148-1153Tumour Biol.2015, 36(9):7027-34Cell Physiol Biochem.2019, 52(6):1255-1266Biomed Chromatogr.2019, 8:e4774Nutrients.2018, 10(7)Eur J Pharmacol.2020, 889:173589.Planta Med.2018, 84(6-07):465-474Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2020, 37(9):1437-1448.J of Applied Pharmaceutical Science2020, 10(1):077-082Sci Rep.2019, 9(1):4342
Related Screening Libraries
||Darutoside can improve skin elasticity, surface appearance and stretch mark removal, through soothing the skin, decreasing inflammation, restoring collagen and promoting collagen production; it could as an appropriate treatment for wounds.
||Immunology & Inflammation related|
|J Ethnopharmacol. 2014 Oct 28;156:365-9. |
|Comparisons of the chemical profiles, cytotoxicities and anti-inflammatory effects of raw and rice wine-processed Herba Siegesbeckiae.[Pubmed: 25278181]|
|Although slightly toxic, the Chinese medicinal herb Herba Siegesbeckiae (HS) has long been used as a remedy for traditional Chinese medicine symptoms that resemble inflammatory joint disorders, because it can eliminate the wind-dampness and soothe painful joints. Proper processing can reduce the toxicity and/or enhance the efficacy of raw herbs. In this study, we aim to examine if processing with rice wine reduces the cytotoxicities and/or enhances the anti-inflammatory effects of HS, and to explore the chemical basis behind the potential changes of medicinal properties caused by the processing.
METHODS AND RESULTS:
We used cell models to examine the cytotoxicities and anti-inflammatory effects of HS and rice wine-processed HS (WHS). The chemical profiles of HS and WHS were compared using the ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS) analysis.
We found that WHS was less toxic than HS in cultured cells as shown in the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Both HS and WHS had anti-inflammatory effects as demonstrated by their abilities to reduce nitric oxide (NO) production as well as protein and mRNA expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Interestingly, the anti-inflammatory effects of WHS were more potent than that of HS at the concentration of 100 μg/mL. By comparing the chemical profiles, we found that 19 peaks were lower, while 2 other peaks were higher in WHS than in HS. Four compounds including neo-Darutoside, Darutoside, stigmasterol and 16-O-acetylDarutoside corresponding to 4 individual changed peaks were tentatively identified by matching with empirical molecular formulae and mass fragments.
Our study showed that processing with rice wine significantly reduced the cytotoxicities and enhanced the anti-inflammatory effects of HS as demonstrated in cell models. We also developed a UPLC/Q-TOF-MS method to clearly differentiate HS from WHS by their different chemical profiles. Further study is warranted to establish the relationship between the alteration of chemical profiles and the changes of medicinal properties caused by processing with rice wine.
||The herbs of Siegesbeckia orientalis.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Zhongguo Zhong Yao Za Zhi. 2014 Aug;39(15):2907-11. |
|Study on index components and fingerprints of crude and processed Siegesbeckia Herbs.[Pubmed: 25507552]|
|The change of kirenol, darutigenol and Darutoside in Siegesbeckia and its first to ninth processed products were studied, and the ten fingerprints were compared, which provided the experimental basis for the study of Siegesbeckia processing tech- nology.
METHODS AND RESULTS:
The samples were analysed by HPLC on a SunFire-C18 column (4.6 mm x 150 mm, 5 μm) with gradient elution of acetonitrile (0.1% formic acid)-water (0.1% formic acid) at a flow rate of 1.0 mL x min(-1). Column temperaturewas 30 °C and the detected wavelength was 215, 320 nm. The calibration curves of kirenol, darutigenol and Darutoside were linear in the range of 2.180-26.16, 2.900-34.80, and 1.012-6.072 mg x L(-1), respectively, and the average recoveries were 96.4%, 97.2% and 96.3% wit RSD 2.2%, 1.7% and 2.4%.
This method was simple, the result was stable and had good repeatability, recovery and precision. The result was the basis of the chemical contents variation in the processing of Siegesbeckia Herbs and further clarifying the effect of the changing.