3,4,5-Tricaffeoylquinic acid | CAS:86632-03-3

3,4,5-Tricaffeoylquinic acid

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Description:

3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-ĸB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease. 3,4,5-Tricaffeoylquinic acid may attenuate the proteasome inhibitor-induced programmed cell death in PC12 cells by suppressing the activation of the mitochondrial pathway and the caspase-8- and Bid-dependent pathways, the effect be attributed to its inhibitory effect on the formation of reactive oxygen species and depletion of GSH.

Targets:

HIV | TNF-α | Akt | NF-kB | Beta Amyloid | Bcl-2/Bax | p53 | Caspase | p53 | IL Receptor | ERK

In vitro:

Int Immunopharmacol. 2011 Nov;11(11):1715-23.

3,4,5-Tricaffeoylquinic acid inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways.[Pubmed: 21704193]

Keratinocytes may play an important role in the pathogenesis of skin disease in atopic dermatitis. Caffeoyl derivatives are demonstrated to have anti-inflammatory and anti-oxidant effects. However, the effect of 3,4,5-Tricaffeoylquinic acid prepared from Aconium koreanum on the pro-inflammatory cytokine-stimulated keratinocyte responses remains uncertain.
METHODS AND RESULTS:
In human keratinocytes, we investigated the effect of 3,4,5-Tricaffeoylquinic acid on the tumor necrosis factor (TNF)-α-stimulated production of inflammatory mediators in relation to the nuclear factor (NF)-κB and cell signaling Akt, which regulates the transcription genes involved in immune and inflammatory responses. 3,4,5-Tricaffeoylquinic acid inhibited the TNF-α-stimulated production of cytokines (IL-1β and IL-8) and chemokine (CCL17 and CCL27) in keratinocytes. Bay 11-7085 (an inhibitor of NF-κB activation) and Akt inhibitor attenuated the TNF-α-induced formation of inflammatory mediators. 3,4,5-Tricaffeoylquinic acid, Bay 11-7085, Akt inhibitor and N-acetylcysteine inhibited the TNF-α-induced activation of NF-κB, activation of Akt, and formation of reactive oxygen and nitrogen species. The results show that 3,4,5-Tricaffeoylquinic acid seems to attenuate the TNF-α-stimulated inflammatory mediator production in keratinocytes by suppressing the activation of Akt and NF-κB pathways which may be mediated by reactive oxygen species.
CONCLUSIONS:
The findings suggest that 3,4,5-Tricaffeoylquinic acid may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease.

Pharmacology. 2012;90(3-4):183-92.

3,4,5-tricaffeoylquinic Acid inhibits the lipopolysaccharide-stimulated production of inflammatory mediators in keratinocytes.[Pubmed: 22947851 ]

Microbial product lipopolysaccharide (LPS) has been shown to be involved in the pathogenesis of inflammatory skin diseases. Caffeoyl derivatives have demonstrated anti-inflammatory and antioxidant effects. However, the effect of 3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) on the production of microbial product-induced inflammatory mediators in keratinocytes has not yet been studied.
METHODS AND RESULTS:
Using human keratinocytes, we investigated the effect of 3,4,5-Tricaffeoylquinic acid on the LPS-stimulated production of inflammatory mediators in relation to the nuclear factor (NF)-ĸB, Akt and ERK pathways. 3,4,5-Tricaffeoylquinic acid inhibited the LPS-induced expression of Toll-like receptor 4, and the production of cytokines and chemokines in keratinocytes. 3,4,5-Tricaffeoylquinic acid, Bay 11-7085, Aĸt inhibitor and ERK inhibitor each attenuated the LPS-induced production of inflammatory mediators by inhibiting the NF-ĸB, Akt and ERK pathways.
CONCLUSIONS:
3,4,5-Tricaffeoylquinic acid may attenuate the LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-ĸB pathways. 3,4,5-Tricaffeoylquinic acid may exert a preventive effect against microbial product-induced inflammatory skin diseases.

In vivo:

Aging (Albany NY) . 2019 Jan 17;11(2):401-422.

3,4,5-Tricaffeoylquinic acid induces adult neurogenesis and improves deficit of learning and memory in aging model senescence-accelerated prone 8 mice[Pubmed: 30654329]

Abstract Caffeoylquinic acid (CQA) is a natural polyphenol with evidence of antioxidant and neuroprotective effects and prevention of deficits in spatial learning and memory. We studied the cognitive-enhancing effect of 3,4,5-Tricaffeoylquinic acid (TCQA) and explored its cellular and molecular mechanism in the senescence-accelerated mouse prone 8 (SAMP8) model of aging and Alzheimer's disease as well as in human neural stem cells (hNSCs). Mice were fed with 5 mg/kg of TCQA for 30 days and were tested in the Morris water maze (MWM). Brain tissues were collected for immunohistochemical detection of bromodeoxyuridine (BrdU) to detect activated stem cells and newborn neurons. TCQA-treated SAMP8 exhibited significantly improved cognitive performance in MWM compared to water-treated SAMP8. TCQA-treated SAMP8 mice also had significantly higher numbers of BrdU+/glial fibrillary acidic protein (GFAP+) and BrdU+/Neuronal nuclei (NeuN+) cells in the dentate gyrus (DG) neurogenic niche compared with untreated SAMP8. In hNSCs, TCQA induced cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling. The neurogenesis promoting effect of TCQA in the DG of SAMP8 mice might explain the cognition-enhancing influence of TCQA observed in our study, and our hNSCs in aggregate suggest a therapeutic potential for TCQA in aging-associated diseases. Keywords: BMP signaling; SAMP8; TCQA; neurogenesis; spatial learning and memory.

3,4,5-Tricaffeoylquinic acid Description

Source:	The herbs of Aconium koreanum.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Neurochem Res. 2014 Aug;39(8):1416-25.

3,4,5-tricaffeoylquinic acid attenuates proteasome inhibition-mediated programmed cell death in differentiated PC12 cells.[Pubmed: 24825618]

The dysfunction of the proteasome system is suggested to be implicated in neuronal degeneration. Caffeoylquinic acid derivatives have demonstrated anti-oxidant and anti-inflammatory effects. However, the effect of 3,4,5-Tricaffeoylquinic acid on the neuronal cell death induced by proteasome inhibition has not been studied.
METHODS AND RESULTS:
Therefore, in the respect of cell death process, we assessed the effect of 3,4,5-Tricaffeoylquinic acid on the proteasome inhibition-induced programmed cell death using differentiated PC12 cells. The proteasome inhibitors MG132 and MG115 induced a decrease in Bid, Bcl-2, and survivin protein levels, an increase in Bax, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3), and an increase in the tumor suppressor p53 levels. Treatment with 3,4,5-Tricaffeoylquinic acid attenuated the proteasome inhibitor-induced changes in the programmed cell death-related protein levels, formation of reactive oxygen species, GSH depletion and cell death.
CONCLUSIONS:
The results show that 3,4,5-Tricaffeoylquinic acid may attenuate the proteasome inhibitor-induced programmed cell death in PC12 cells by suppressing the activation of the mitochondrial pathway and the caspase-8- and Bid-dependent pathways. The preventive effect of 3,4,5-Tricaffeoylquinic acid appears to be attributed to its inhibitory effect on the formation of reactive oxygen species and depletion of GSH.

CAS No.	86632-03-3	Price	$318 / 5mg
Catalog No.	CFN90238	Purity	>=98%
Molecular Weight	678.59	Type of Compound	Phenylpropanoids
Formula	C₃₄H₃₀O₁₅	Physical Description	Powder
Download	COA MSDS SDF Manual	Similar structural	Comparison (Web) (SDF)

Product Name	3,4,5-Tricaffeoylquinic acid
CAS No.:	86632-03-3
Catalog No.:	CFN90238
Molecular Formula:	C₃₄H₃₀O₁₅
Molecular Weight:	678.59 g/mol
Purity:	>=98%
Type of Compound:	Phenylpropanoids
Physical Desc.:	Powder
Targets:	HIV \| TNF-伪 \| Akt \| NF-kB \| Beta Amyloid \| Bcl-2/Bax \| p53 \| Caspase \| p53 \| IL Receptor \| ERK
Source:	The herbs of Aconium koreanum.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Price:	$318 / 5mg
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.4736 mL	7.3682 mL	14.7364 mL	29.4729 mL	36.8411 mL
5 mM	0.2947 mL	1.4736 mL	2.9473 mL	5.8946 mL	7.3682 mL
10 mM	0.1474 mL	0.7368 mL	1.4736 mL	2.9473 mL	3.6841 mL
50 mM	0.0295 mL	0.1474 mL	0.2947 mL	0.5895 mL	0.7368 mL
100 mM	0.0147 mL	0.0737 mL	0.1474 mL	0.2947 mL	0.3684 mL

CFN91944	3,5-Dicaffeoyl-epi-quinic acid	879305-14-3	516.45	C₂₅H₂₄O₁₂
CFN90857	3,5-Di-O-caffeoylquinic acid methyl ester	159934-13-1	530.5	C₂₆H₂₆O₁₂
CFN99120	Isochlorogenic acid C	32451-88-0	516.45	C₂₅H₂₄O₁₂
CFN95405	Isochlorogenic acid C 4'-O-glucoside	N/A	678.6	C₃₁H₃₄O₁₇
CFN90858	4,5-Di-O-caffeoylquinic acid methyl ester	188742-80-5	530.5	C₂₆H₂₆O₁₂
CFN90238	3,4,5-Tricaffeoylquinic acid	86632-03-3	678.59	C₃₄H₃₀O₁₅
CFN00384	Caftaric acid	67879-58-7	312.2	C₁₃H₁₂O₉
CFN99725	Chicoric acid	6537-80-0	474.37	C₂₂H₁₈O₁₂
CFN99122	1,4-Dicaffeoylquinic acid	1182-34-9	516.46	C₂₅H₂₄O₁₂
CFN90937	1,5-Dicaffeoylquinic acid	19870-46-3	516.5	C₂₅H₂₄O₁₂