ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Phytomedicine.2019, 59:152785PLoS One.2022, 17(6):e0268505. Plant Sci.2020, 301:110656.Antioxidants (Basel).2022, 11(8):1471.Toxicol Res.2019, 35(4):371-387Molecules.2021, 26(6):1635. Srinagarind Medical Journal2019, 34(1)Free Radic Biol Med.2021, 166:104-115.
Journal of Plant Growth Regulatio...2022...Viruses.2017, 9(10)Gene.2022, 815:146178.Industrial Crops and Products...2021...J. Traditional Thai Medical Res. ...2022...J Bone Miner Res.2017, 32(12):2415-2430Biochem Biophys Res Commun....2020...Evid Based Complement Alternat Me...2017...
Nutrients.2019, 12(1):E40Drug Des Devel Ther.2020, 14:969-976.J Sep Sci.2018, 41(7):1682-1690Molecules.2021, 26(2):E255.Sains Malaysiana2022, 51(4):1143-1154Drug Des Devel Ther.2020, 14:61-71Phytochemistry Letters2015, 243-247
Our products had been exported to the following research institutions and universities, And still growing.
The Institute of Cancer Research (United Kingdom)Melbourne University (Australia)Weizmann Institute of Science (Israel)The University of Newcastle (Australia)
University of East Anglia (United Kingdom)Utrecht University (Netherlands)Monash University Sunway Campus (Malaysia)Kyung Hee University (Korea)
Tohoku University (Japan)Institute of Bioorganic Chemist... (Poland)University of Illinois at Chicago (USA)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Pharmacognosy Magazine2017, 13(52):868-874Evid Based Complement Alternat Med.2017, 2017:7383104Toxicol In Vitro.2022, 81:105346. Eur J Pharmacol.2020, 889:173589.Int J Mol Sci.2021, 22(10):5181.Biol Pharm Bull.2018, 41(11):1685-1693Anal Bioanal Chem.2016, 408(1):177-90. Asian Pac J Cancer Prev.2019, 20(1):65-72Molecules.2019, 24(7):E1290Phytomedicine.2019, 59:152785
Related Screening Libraries
||Dasycarpol(9beta-Hydroxyfraxinellone) shows significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at a concentration of 0.1 microM. Dasycarpol also shows moderate inhibitory activity on lung cancer cell line A549.
|J Nat Prod. 2008 Feb;71(2):208-11. |
|Neuroprotective limonoids of root bark of Dictamnus dasycarpus.[Pubmed: 18198838]|
METHODS AND RESULTS:
A methanolic extract of Dictamnus dasycarpus root bark afforded four new degraded limonoids, 9alpha-hydroxyfraxinellone-9- O-beta- d-glucoside ( 1), dictamnusine ( 2), dictamdiol A ( 3), and dictamdiol B ( 4), together with eight known compounds, dictamdiol ( 5), fraxinellone ( 6), fraxinellonone ( 7), 9beta-hydroxyfraxinellone (Dasycarpol,8), calodendrolide ( 9), obacunone ( 10), limonin ( 11), and rutaevin ( 12).
Compounds, 2, 3, 6, 9, 10, and 11 showed significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at a concentration of 0.1 microM.
||The root barks of Dictamnus dasycarpus.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Asian Nat Prod Res. 2005 Dec;7(6):843-5. |
|Microbial transformation of fraxinellone by Aspergillus niger.[Pubmed: 16308202 ]|
METHODS AND RESULTS:
Microbial transformation of fraxinellone (1) by Aspergillus niger (AS 3.421) has been carried out. Two converted products, Dasycarpol (2) and a new compound fraxinigerllone (3) were obtained. Their structures have been identified on the basis of spectroscopic methods.
Dasycarpol shows moderate inhibitory activity on lung cancer cell line A549.
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