ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $144.7 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Molecules. 2013, 18(7):7376-88Inflammation2015, 38(1):445-55Acta Pharm Sin B.2015, 5(4):323-9.J. Soc. Cosmet. Sci. Korea2016, 163-171Int J Mol Med.2016, 37(2):501-8Am J Chin Med.2016, 44(8):1719-1735Int J Anal Chem.2017, 2017:1254721Cell Physiol Biochem....2017...
Nutrients.2018, 10(10)Lab Chip.2018, 18(6):971-978Asian Journal of Chemistry...2018...BMC Complement Altern Med....2019...J Ethnopharmacol.2019, 228:132-141Chem Biol Interact.2019, 315:108910Food and Fermentation Industries...2019...J Food Sci Technol....2019...
Appl Biol Chem2019, 62:46Plos One.2020, 10.1371Biomolecules.2020, 10(6):925.LWT2020, 130:109535Int J Mol Sci.2020, 21(9):3239.Plants (Basel).2020, 9(11):1555.Toxicological Research...2020...
Our products had been exported to the following research institutions and universities, And still growing.
University of Illinois at Chicago (USA)Guangzhou Institutes of Biomedi... (China)Anna University (India)Subang Jaya Medical Centre (Malaysia)
University of Ioannina (Greece)Nanjing University of Chinese M... (China)Wageningen University (Netherlands)Center for protein Engineering ... (Belgium)
Heinrich-Heine-University Düss... (Germany)Uniwersytet Jagielloński w Kra... (Poland)Charles University in Prague (Czech Republic)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
J of Engineering Science&Technology2018, 13(9):2820-2828Planta Med.2019, 85(9-10):766-773Horticulturae2021, 7(1),5.Biomed Pharmacother.2020, 128:110318.Phytomedicine.2019, 55:229-237Free Radic Biol Med.2016, 97:307-319TCI CO.2019, US20190151257A1Phytother Res.2016, 30(12):2020-2026Drug Des Devel Ther.2020, 14:969-976.Nutrients.2019, 12(1)
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Flavonoids Compound Library
||Hamaudol has analgesic and anti-inflammary activities, it showed inhibitory activity on COX-1 and COX-2 activities with values of 0.30, 0.57 mM, respectively. |
||COX-1 | COX-2|
|Chem Pharm Bull (Tokyo). 1999 Jan;47(1):96-100. |
|Antiproliferative constituents from umbelliferae plants. V. A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica.[Pubmed: 9987830 ]|
METHODS AND RESULTS:
The CHCl3 extract of the root of Angelica japonica showed high inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. From this extract, a new furanocoumarin named japoangelone and four furanocoumarin ethers of falcarindiol, named japoangelols A-D, were isolated together with caffeic acid methyl ester, four polyacetylenic compounds (panaxynol, falcarindiol, 8-O-acetylfalcarindiol, and (9Z)-1,9-heptadecadiene-4,6-diyne-3,8,11-triol), eight coumarins (osthol, isoimperatorin, scopoletin, byakangelicin, xanthotoxin, bergapten, oxypeucedanin methanolate, and oxypeucedanin hydrate), and two chromones (3'-O-acetylHamaudol, and Hamaudol).
The structures of the new isolates were determined based on spectral evidence. The ED50 of isolates against MK-1, HeLa, and B16F10 cell lines are reported.
| Korean Journal of Medicinal Crop Science, 2005, 13(2). |
|The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity[Reference: WebLink]|
METHODS AND RESULTS:
Five coumarins, psoralen (1), scopoletin (2), isoimperatorin (4), (+)-marmesin (5) and xanthotoxin (6), three chromones, cimifugin (3), Hamaudol (7) and sec-O-glucosylHamaudol (10), one sterol, daucosterol (8) and one aliphatic alcohol, galactitol (9) were isolated from the root of Peucedanum japonicum. Their chemical structures were identified by the physicochemical and spectroscopic data by comparing literature values. Among them, compounds 9 and 10 were isolated for the first time from this plant.
The anti-inflammatory effects of isolated compounds were examined on cyclooxygenase (COX), compounds 1, 2 and 7 showed inhibitory activity on COX-1 with values of 0.88, 0.27 and 0.30 mM, respectively. In the test for COX-2 activity, only compound 7 showed significant inhibitory activity with the value of 0.57 mM. The other compounds exhibited weak inhibitory or no inhibitory activity.
|Chem Pharm Bull (Tokyo). 2001 Feb;49(2):154-60. |
|Analgesic components of saposhnikovia root (Saposhnikovia divaricata).[Pubmed: 11217101 ]|
METHODS AND RESULTS:
By activity-oriented separation using the writhing method in mice, the analgesic components of Saposhnikovia root (Saposhnikovia divaricata Schischkin; Umbelliferae) were identified to be chromones, coumarins, polyacetylenes and 1-acylglycerols. Two new components, divaricatol and (3'S)-hydroxydeltoin, were also isolated.
The most potent analgesia was observed in chromones such as divaricatol, ledebouriellol and Hamaudol, which inhibited writhing inhibition at an oral dose of 1 mg/kg in mice. Acylglycerols also showed inhibition significantly at a dose of 5 mg/kg. In some pharmacological tests using sec-O-glucosylHamaudol, the compound showed analgesia by the tail pressure and the Randall & Selitto methods, and its writhing inhibition was not reversed by naloxone.
||The herbs of Ledebouriella seseloides
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.