6'''-Feruloylspinosin | CAS:77690-92-7

6'''-Feruloylspinosin

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Size /Price /Stock	10 mM * 1 mL in DMSO / $133.0 / In-stock
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Description:

6'''-Feruloylspinosin may possess anti-inflammatory activity.

Targets:

NF-kB | p65

In vitro:

J Agric Food Chem. 2011 Jun 22;59(12):6594-604.

Distribution of free amino acids, flavonoids, total phenolics, and antioxidative activities of Jujube (Ziziphus jujuba) fruits and seeds harvested from plants grown in Korea.[Pubmed: 21574660]

Fruit pulp and seeds from the jujube plant possess nutritional and medicinal properties. The bioactive components have been shown to vary both with cultivar and with growing conditions. Most studies report the components of varieties from China.
METHODS AND RESULTS:
We measured free amino acid, individual phenolic, and total phenolic content, and antioxidative activities in three jujube fruit pulp extracts from Boeun-deachu, Mechu, and Sanzoin cultivars and two seed extracts (Mechu and Sanzoin) from plants grown in Korea. In g/100 g dry weight, total free amino acid content measured by ion-exchange chromatography ranged from 5.2 to 9.8 in the pulp and from 4.0 to 5.3 in the seed. Total phenolic content measured by Folin-Ciocalteu ranged from 1.1 to 2.4 in the pulp and from 3.6 to 4.6 in the seed. Flavonoids were measured by HPLC and ranged from 0.7 to 1.8 in the pulp and from 3.2 to 4.0 in the seed. Flavonoids were identified by HPLC elution position and UV/vis and mass spectra. Fruits contained the following flavonoids: procyanidin B2, epicatechin, quercetin-3-O-rutinoside (Q-3-R), quercetin-3-O-galactoside (Q-3-G), kaempferol-glucosyl-rhamnoside (K-G-R), and two unidentified compounds. Seeds contained the following flavonoids: saponarin, spinosin, vitexin, swertish, 6'''-hydroxybenzoylspinosin (6'''-HBS), 6'''-Feruloylspinosin (6'''-FS), and one unidentified substance. Dimensions and weights of the fresh fruit samples affected phenolic content. The distribution of the individual flavonoids among the different samples varied widely. Data determined by the FRAP antioxidative assay were well correlated with total phenolic content. In a departure from other studies, data from the DPPH free radical assay were not correlated with FRAP or with any of the measured compositional parameters.
CONCLUSIONS:
Because individual jujube flavonoids are reported to exhibit different health-promoting effects, knowledge of the composition and concentration of bioactive compounds of jujube products can benefit consumers.

6'''-Feruloylspinosin Description

Source:	The seeds of Ziziphus jujuba Mill. var. spinosa
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Cell Research:

Phytomedicine. 2016 Mar 15;23(3):293-306.

Evaluating ancient Egyptian prescriptions today: Anti-inflammatory activity of Ziziphus spina-christi.[Pubmed: 26969383]

To determine the active ingredients of Z. spina-christi, we fractionated the extracts for bioassays and identified the active compounds.
METHODS AND RESULTS:
Epigallocatechin, gallocatechin, spinosin, 6'''-Feruloylspinosin and 6''' sinapoylspinosin and crude extracts of seed, leaf, root or stem were analyzed for their effect on NF-κB DNA binding by electromobility shift assay (EMSA) and nuclear translocation of NF-κB-p65 by Western blot analysis. The binding mode of the compounds to NF-κB pathway proteins was compared with the known inhibitor, MG-132, by in silico molecular docking calculations. Log10IC50 values of gallocatechin and epigallocatechin as two main compounds of the plant were correlated to the microarray-based mRNA expression of 79 inflammation-related genes in cell lines of the National Cancer Institute (NCI, USA) as determined. The expression of 17 genes significantly correlated to the log10IC50 values for gallocatechin or epigallocatechin. Nuclear p65 protein level decreased upon treatment with each extract and compound. Root and seed extracts inhibited NF-κB-DNA binding as shown by EMSA. The compounds showed comparable binding energies and similar docking poses as MG-132 on the target proteins.
CONCLUSIONS:
Z. spina-christi might possess anti-inflammatory activity as assumed by ancient Egyptian prescriptions. Five compounds contributed to this bioactivity, i.e. epigallocatechin, gallocatechin, spinosin, 6'''-Feruloylspinosin and 6''' sinapoylspinosin as shown in vitro and in silico.

Structure Identification:

J Asian Nat Prod Res. 2011 Dec;13(12):1151-7.

A novel spinosin derivative from Semen Ziziphi Spinosae.[Pubmed: 22115038]

METHODS AND RESULTS:
A novel spinosin derivative, 6‴-(4‴'-O-β-D-glucopyranosyl)-vanilloyl spinosin (1) was isolated from the methanol extract of Semen Ziziphi Spinosae, together with five known flavonoids, swertish, spinosin, 6'''-Feruloylspinosin , isospinosin and kaempferol 3-O-α-L-rhamnopyranosyl-(1 → 2)-O-[O-α-L-rhamnopyranosyl-(1 → 6)]-β-D-glucopyranoside, and two alkanoids, zizyphusine and 6-(2',3'-dihydroxyl-4'-hydroxymethyl-tetrahydro-furan-1'-yl)-cyclopentene[c]pyrrole-1,3-diol.
CONCLUSIONS:
The structure of compound 1 was elucidated by spectroscopic methods including UV, IR, ESI-TOF-MS, 1D, and 2D NMR techniques.

CAS No.	77690-92-7	Price	$238 / 20mg
Catalog No.	CFN90665	Purity	>=98%
Molecular Weight	784.71	Type of Compound	Flavonoids
Formula	C₃₈H₄₀O₁₈	Physical Description	Yellow powder
Download	COA MSDS SDF	Similar structural	Comparison (Web) (SDF)

Product Name	6'''-Feruloylspinosin
CAS No.:	77690-92-7
Catalog No.:	CFN90665
Molecular Formula:	C₃₈H₄₀O₁₈
Molecular Weight:	784.71 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Targets:	NF-kB \| p65
Source:	The seeds of Ziziphus jujuba Mill. var. spinosa
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Price:	$238 / 20mg

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Flavonoids Compound Library p65 Inhibitor Library NF-kB Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2744 mL	6.3718 mL	12.7436 mL	25.4871 mL	31.8589 mL
5 mM	0.2549 mL	1.2744 mL	2.5487 mL	5.0974 mL	6.3718 mL
10 mM	0.1274 mL	0.6372 mL	1.2744 mL	2.5487 mL	3.1859 mL
50 mM	0.0255 mL	0.1274 mL	0.2549 mL	0.5097 mL	0.6372 mL
100 mM	0.0127 mL	0.0637 mL	0.1274 mL	0.2549 mL	0.3186 mL

CFN95296	Isosaponarin 2''-O-glucoside (Isovitexin-2''-4'-di-O-beta-D-glucoside)	63316-27-8	756.7	C₃₃H₄₀O₂₀
CFN95252	Vaccarin E	2252345-81-4	904.8	C₄₂H₄₈O₂₂
CFN90134	Saponarin	20310-89-8	594.52	C₂₇H₃₀O₁₅
CFN90621	Swertisin	6991-10-2	446.4	C₂₂H₂₂O₁₀
CFN99600	Spinosin	72063-39-9	608.55	C₂₈H₃₂O₁₅
CFN90665	6'''-Feruloylspinosin	77690-92-7	784.71	C₃₈H₄₀O₁₈
CFN98601	Vitexin	3681-93-4	432.4	C₂₁H₂₀O₁₀
CFN93575	Vitexin argininate	N/A	606.6	C₂₇H₃₄N₄O₁₂
CFN70343	Vitexin 7-glucoside	35109-95-6	594.5	C₂₇H₃₀O₁₅
CFN90654	Vitexin 2''-O-p-coumarate	59282-55-2	578.5	C₃₀H₂₆O₁₂